FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739731615> ?p ?o ?g. }

• W2739731615 endingPage "742" @default.
• W2739731615 startingPage "737" @default.
• W2739731615 abstract "Modified mRNA (mod-mRNA) has recently been widely studied as the form of RNA useful for therapeutic applications due to its high stability and lowered immune response. Herein, we extend the scope of the recently established RNA-TAG (transglycosylation at guanosine) methodology, a novel approach for genetically encoded site-specific labeling of large mRNA transcripts, by employing mod-mRNA as substrate. As a proof of concept, we covalently attached a fluorescent probe to mCherry encoding mod-mRNA transcripts bearing 5-methylcytidine and/or pseudouridine substitutions with high labeling efficiencies. To provide a versatile labeling methodology with a wide range of possible applications, we employed a two-step strategy for functionalization of the mod-mRNA to highlight the therapeutic potential of this new methodology. We envision that this novel and facile labeling methodology of mod-RNA will have great potential in decorating both coding and noncoding therapeutic RNAs with a variety of diagnostic and functional moieties." @default.
• W2739731615 created "2017-08-08" @default.
• W2739731615 creator A5004466333 @default.
• W2739731615 creator A5017056914 @default.
• W2739731615 creator A5018498392 @default.
• W2739731615 creator A5027107238 @default.
• W2739731615 creator A5057387819 @default.
• W2739731615 date "2017-07-27" @default.
• W2739731615 modified "2023-10-12" @default.
• W2739731615 title "Site-Specific Covalent Conjugation of Modified mRNA by tRNA Guanine Transglycosylase" @default.
• W2739731615 cites W1811819477 @default.
• W2739731615 cites W1963706689 @default.
• W2739731615 cites W1977176074 @default.
• W2739731615 cites W1980232662 @default.
• W2739731615 cites W1999185664 @default.
• W2739731615 cites W2001629378 @default.
• W2739731615 cites W2015057312 @default.
• W2739731615 cites W2049362603 @default.
• W2739731615 cites W2050839209 @default.
• W2739731615 cites W2055676760 @default.
• W2739731615 cites W2058647478 @default.
• W2739731615 cites W2070511522 @default.
• W2739731615 cites W2071302752 @default.
• W2739731615 cites W2077662282 @default.
• W2739731615 cites W2077956480 @default.
• W2739731615 cites W2086969519 @default.
• W2739731615 cites W2098419906 @default.
• W2739731615 cites W2099053774 @default.
• W2739731615 cites W2115495500 @default.
• W2739731615 cites W2116511587 @default.
• W2739731615 cites W2124213396 @default.
• W2739731615 cites W2145768602 @default.
• W2739731615 cites W2146685096 @default.
• W2739731615 cites W2151589963 @default.
• W2739731615 cites W2151709132 @default.
• W2739731615 cites W2172976811 @default.
• W2739731615 cites W2281696593 @default.
• W2739731615 cites W2282836196 @default.
• W2739731615 cites W2285232484 @default.
• W2739731615 cites W2303964045 @default.
• W2739731615 cites W2345270442 @default.
• W2739731615 cites W2462639992 @default.
• W2739731615 cites W2512985714 @default.
• W2739731615 cites W2525553968 @default.
• W2739731615 cites W2549483633 @default.
• W2739731615 cites W2565596567 @default.
• W2739731615 doi "https://doi.org/10.1021/acs.molpharmaceut.7b00356" @default.
• W2739731615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28749687" @default.
• W2739731615 hasPublicationYear "2017" @default.
• W2739731615 type Work @default.
• W2739731615 sameAs 2739731615 @default.
• W2739731615 citedByCount "18" @default.
• W2739731615 countsByYear W27397316152018 @default.
• W2739731615 countsByYear W27397316152019 @default.
• W2739731615 countsByYear W27397316152020 @default.
• W2739731615 countsByYear W27397316152021 @default.
• W2739731615 countsByYear W27397316152022 @default.
• W2739731615 countsByYear W27397316152023 @default.
• W2739731615 crossrefType "journal-article" @default.
• W2739731615 hasAuthorship W2739731615A5004466333 @default.
• W2739731615 hasAuthorship W2739731615A5017056914 @default.
• W2739731615 hasAuthorship W2739731615A5018498392 @default.
• W2739731615 hasAuthorship W2739731615A5027107238 @default.
• W2739731615 hasAuthorship W2739731615A5057387819 @default.
• W2739731615 hasConcept C104317684 @default.
• W2739731615 hasConcept C105580179 @default.
• W2739731615 hasConcept C153911025 @default.
• W2739731615 hasConcept C153957851 @default.
• W2739731615 hasConcept C181199279 @default.
• W2739731615 hasConcept C185592680 @default.
• W2739731615 hasConcept C2777995097 @default.
• W2739731615 hasConcept C2778301229 @default.
• W2739731615 hasConcept C2779810333 @default.
• W2739731615 hasConcept C2781184954 @default.
• W2739731615 hasConcept C512185932 @default.
• W2739731615 hasConcept C55493867 @default.
• W2739731615 hasConcept C67705224 @default.
• W2739731615 hasConcept C70721500 @default.
• W2739731615 hasConcept C86803240 @default.
• W2739731615 hasConceptScore W2739731615C104317684 @default.
• W2739731615 hasConceptScore W2739731615C105580179 @default.
• W2739731615 hasConceptScore W2739731615C153911025 @default.
• W2739731615 hasConceptScore W2739731615C153957851 @default.
• W2739731615 hasConceptScore W2739731615C181199279 @default.
• W2739731615 hasConceptScore W2739731615C185592680 @default.
• W2739731615 hasConceptScore W2739731615C2777995097 @default.
• W2739731615 hasConceptScore W2739731615C2778301229 @default.
• W2739731615 hasConceptScore W2739731615C2779810333 @default.
• W2739731615 hasConceptScore W2739731615C2781184954 @default.
• W2739731615 hasConceptScore W2739731615C512185932 @default.
• W2739731615 hasConceptScore W2739731615C55493867 @default.
• W2739731615 hasConceptScore W2739731615C67705224 @default.
• W2739731615 hasConceptScore W2739731615C70721500 @default.
• W2739731615 hasConceptScore W2739731615C86803240 @default.
• W2739731615 hasFunder F4320332603 @default.
• W2739731615 hasFunder F4320338281 @default.
• W2739731615 hasIssue "3" @default.
• W2739731615 hasLocation W27397316151 @default.

• next