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- W2739736741 abstract "ABSTRACT - In the past few years, the monoclonal antibody MIB-1 has been used by researchers in order toretrospectively study paraffin imbibed tumor fragments. The medulloblastoma is the most common malignantcentral nervous system tumor in childhood. The objectives were: determination of the mean Mib-1 LI valuefrom these patients, as well as the prognostic value of the method.This retrospective study represents ananalysis of the cellular proliferation index of posterior fossa medulloblastomas collected from 22 patients atA.C. Camargo Hospital, from January 1990 to December 1999. The histopathological diagnosis was confirmedby H&E and proliferative index (LI) was achived with Mib-1 which detects proliferating cells during G1, G2, Sand M phases.The results demostrated that the mean Mib-1 was 30,1%, and ranged from 5,2% to 62,0%.Inconclusion, this method has prognostic value, has to be used as routine for patients harboring medulloblastomasand the ones who have PI greater than the mean value found in this study, should be treated aggressively.KEY WORDS: medulloblastoma, labelling index (LI), MIB-1,prognostic factors." @default.
- W2739736741 created "2017-08-08" @default.
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- W2739736741 date "2003-01-01" @default.
- W2739736741 modified "2023-09-22" @default.
- W2739736741 title "Evaluation of proliferative index by monoclonal antibody Mib-1, its prognostic correlation and therapeutic implications" @default.
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