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- W2739793280 abstract "Critical dysregulated immune pathways, including the key role of B cells as well as the ectopic lymphoneogenesis, are involved in primary Sjogren's syndrome (pSS) pathogenesis. B cells may provide a critical link between the development of tertiary lymphoid tissue within target tissues and the propagation of the autoimmune process. Some data suggest that the subset of patients at high risk of systemic complications is specifically characterized by an active serological profile, suggestive for B-cell chronic activation. Moreover, patients with this clinical or immunological higher risk pattern should receive closer follow-up observation and an earlier and more aggressive immunosuppressive treatment. The need for more effective therapies with less toxic side effects, as well as new insights into B-cell roles in disease pathogenesis, has propelled interest in targeted biological therapies. In this context, specific therapies were proposed, recognizing targets, by monoclonal antibodies, on B-cell membrane (anti-CD20 and anti-CD22), or interfering with B-/T-cell cooperation or inhibiting cytokines in B-cell development or activation, such as B-cell activating factor (BAFF) and interleukin (IL)-6, or organization of ectopic lymphoid structures, as shown for lymphotoxin-β." @default.
- W2739793280 created "2017-08-08" @default.
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- W2739793280 date "2016-01-01" @default.
- W2739793280 modified "2023-10-17" @default.
- W2739793280 title "Novel Therapeutic Strategies in Sjögren’s Syndrome" @default.
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- W2739793280 doi "https://doi.org/10.1016/b978-0-12-803604-4.00018-6" @default.
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