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- W2739802012 abstract "The axis of LIN-28B, let-7a and IGF-II has been shown to be involved in human diseases. Several func- tional intronic single nucleotide polymorphisms (SNPs) rs314276 in LIN-28B and rs4320932 in IGF-II are found to be associated with epithelial ovarian cancer (EOC) or its risk factors. SNPs in pri- or pre-miRNAs may affect miRNA expression, but it is unclear whether rs731085 in let-7a-3 influences let-7a or pri-/pre-let-7a-3 levels. It is also not known if these SNPs in combination have a joint effect on EOC. Here we analyzed the LIN-28B/let-7a/IGF-II axis haplotype-specific association with EOC survival by genotyping these SNPs, and mainly assessed the effect of rs731085 genotype on let-7a and pri-/pre-let-7a-3 expression in 211 primary EOC samples. No statistically signifi - cant association was found between the genotype of rs731085 and both let-7a and pri-/pre-let-7a-3 expressions. Multivariate Cox regression analyses showed that rs4320932, but neither rs314276 in LIN-28B nor rs731085 in let-7a-3, was significantly associated with patient overall and progression-free survival. Furthermore, the haplotype G-C-C was associated with increased risk of death, while the haplotype G-C-T was a favorable prognostic indicator. The adjusted hazard ratios for death (HRs) were 1.64 (95% CI: 1.19-2.26) for rs4320932, 1.13 (95% CI: 0.84-1.51) for rs314276, 0.89 (95% CI: 0.66-1.21) for rs731085, 7.48 (95% CI: 1.01-55.7) for the haplotype G-C-C and 0.14 (95% CI: 0.03-0.70) for the haplotype G-C-T, respectively. These results suggest that the haplotype-specific effects are stronger compared to the sum of three individual SNPs, and that the haplotype G-C-C of the axis has an unfavor- able effect on patient overall survival." @default.
- W2739802012 created "2017-08-08" @default.
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- W2739802012 date "2015-01-01" @default.
- W2739802012 modified "2023-09-28" @default.
- W2739802012 title "Original Article Associations of LIN-28B/let-7a/IGF-II axis haplotypes with disease survival in epithelial ovarian cancer" @default.
- W2739802012 cites W14098964 @default.
- W2739802012 cites W144423133 @default.
- W2739802012 cites W1544882311 @default.
- W2739802012 cites W1578805649 @default.
- W2739802012 cites W1584107383 @default.
- W2739802012 cites W1920303762 @default.
- W2739802012 cites W1964901903 @default.
- W2739802012 cites W1966111737 @default.
- W2739802012 cites W1972570808 @default.
- W2739802012 cites W1973816411 @default.
- W2739802012 cites W1976810487 @default.
- W2739802012 cites W1976840283 @default.
- W2739802012 cites W1983031223 @default.
- W2739802012 cites W1985140771 @default.
- W2739802012 cites W1986589033 @default.
- W2739802012 cites W1994786666 @default.
- W2739802012 cites W1998564647 @default.
- W2739802012 cites W2002448742 @default.
- W2739802012 cites W2004714113 @default.
- W2739802012 cites W2005608256 @default.
- W2739802012 cites W2006722291 @default.
- W2739802012 cites W2006797972 @default.
- W2739802012 cites W2009229545 @default.
- W2739802012 cites W2009733794 @default.
- W2739802012 cites W2010352552 @default.
- W2739802012 cites W2010831747 @default.
- W2739802012 cites W2019167811 @default.
- W2739802012 cites W2023372666 @default.
- W2739802012 cites W2028169705 @default.
- W2739802012 cites W2029038784 @default.
- W2739802012 cites W2030714059 @default.
- W2739802012 cites W2034203463 @default.
- W2739802012 cites W2034815318 @default.
- W2739802012 cites W2037995476 @default.
- W2739802012 cites W2039153962 @default.
- W2739802012 cites W2044766199 @default.
- W2739802012 cites W2047333918 @default.
- W2739802012 cites W2048348557 @default.
- W2739802012 cites W2049909920 @default.
- W2739802012 cites W2052360319 @default.
- W2739802012 cites W2063462827 @default.
- W2739802012 cites W2065899119 @default.
- W2739802012 cites W2067213721 @default.
- W2739802012 cites W2069053277 @default.
- W2739802012 cites W2074498980 @default.
- W2739802012 cites W2081835397 @default.
- W2739802012 cites W2082447405 @default.
- W2739802012 cites W2082947145 @default.
- W2739802012 cites W2085463723 @default.
- W2739802012 cites W2088738576 @default.
- W2739802012 cites W2089001345 @default.
- W2739802012 cites W2089171551 @default.
- W2739802012 cites W2094323986 @default.
- W2739802012 cites W2097626332 @default.
- W2739802012 cites W2110666579 @default.
- W2739802012 cites W2112740613 @default.
- W2739802012 cites W2113427027 @default.
- W2739802012 cites W2114896726 @default.
- W2739802012 cites W2115322004 @default.
- W2739802012 cites W2116588813 @default.
- W2739802012 cites W2127951115 @default.
- W2739802012 cites W2129545382 @default.
- W2739802012 cites W2132194692 @default.
- W2739802012 cites W2134823582 @default.
- W2739802012 cites W2135518377 @default.
- W2739802012 cites W2137649483 @default.
- W2739802012 cites W2138069158 @default.
- W2739802012 cites W2142489285 @default.
- W2739802012 cites W2144038313 @default.
- W2739802012 cites W2145702684 @default.
- W2739802012 cites W2146169914 @default.
- W2739802012 cites W2146221021 @default.
- W2739802012 cites W2162001800 @default.
- W2739802012 cites W2162818680 @default.
- W2739802012 cites W2165151551 @default.
- W2739802012 cites W2167116536 @default.
- W2739802012 cites W2167122992 @default.
- W2739802012 cites W2171186404 @default.
- W2739802012 cites W2172157901 @default.
- W2739802012 cites W2330878435 @default.
- W2739802012 cites W3139671960 @default.
- W2739802012 cites W2404630393 @default.
- W2739802012 hasPublicationYear "2015" @default.
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