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• W2739814462 abstract "Objective: Arterial stiffness (AF) measured by cardio-ankle vascular index (CAVI) has been proven to be an early marker of decreasing cardiac, vascular and renal function. However, most of the studies have been conducted in a general practice setting. Therefore, the aim of this study is to determine risk factors of AF in a specific patient's cohort with mildly decreased glomerular filtration rate (GFR). Design and method: This was a retrospective study. Patients were initially recruited in 2011–2013 as participants of the Lithuanian High Cardiovascular Risk primary prevention program. The patients selected for the study had a GFR form 60 to 90 ml/min/1.73sqm in accordance to the KDIGO definition of mildly decreased GFR. The data were grouped into two sections: (1) demographic and comorbidities, (2) laboratory values and instrumental tests. CAVI was chosen as a marker of impaired AF, the cut-off values were generated by implementing the median values of different age and gender groups. Stepwise multivariate logistic regression was performed and risk factors of AF were revealed in each data sections. Results: This study included data of 653 patients aged from 40 to 70 years. Most of them were women 78.3% (n = 511), with a median GFR of 81.49 ml/min/1.73sqm [75.73–86.36]. Six different cut-off values for each gender and age stratified group were generated, with a mean value of 7.7. The implementation of these values showed a distribution across AF groups, favoring the increased AF: 59.7 vs 40.3 percent. The demographic variables and comorbidities associated with AF were: age (OR per year = 1.073, CI95% 1.042–1.105, p < 0.001) and body mass index (OR per kg/sqm = 0.921, CI95% 0.887–0.956, p < 0.001). The laboratory values and instrumental tests related to AF were: ankle-brachial index (OR per 0.1 = 1.426, CI95% 1.103–1.843, p = 0.007), high-density lipoproteins (OR per 0.1 mmol/L = 1.096, CI95% 1.007–1.194, p = 0.034), glucose (OR per mmol/L = 1.296, CI95% 1.088–1.544, p = 0.004) and sodium (OR per mmol/L = 1.117, CI95% 1.009–1.237, p = 0.033). Conclusions: AF in patients with mildly decreased GFR can be predicted by various markers. The most potent predictors were age and ankle-brachial index. These markers should be further studied prospectively in the context of AF and renal function." @default.
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• W2739814462 date "2017-09-01" @default.
• W2739814462 modified "2023-09-26" @default.
• W2739814462 title "[PP.01.33] RISK FACTORS OF ARTERIAL STIFFNESS MEASURED BY CARDIO-ANKLE VASCULAR INDEX IN PATIENTS WITH MILDLY DECREASED GLOMERULAR FILTRATION RATE" @default.
• W2739814462 doi "https://doi.org/10.1097/01.hjh.0000523240.58766.34" @default.
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