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- W2739865720 abstract "The iron(I1) complex of protoporphyrin IX (PpIX)? (heme) is bound to different proteins to form key biomolecules (hemoproteins) such as hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase. The lives of the cells and of the body as a whole is therefore crucially dependent upon the biosynthesis and metabolism of porphyrins. Almost all types of cells of the human body, with the exception of mature red blood cells, are equipped with a machinery to synthesize heme. In the first step of the heme biosynthetic pathway 5-aminolevulinic acid (ALA) is formed from glycine and succinyl CoA. The synthesis of ALA is regulated by the amount of heme in the cell. The last step in the formation of heme is the incorporation of iron into PpIX and takes place in the mitochondria under the action of the enzyme, ferrochelatase. By adding exogenous ALA, PpIX may accumulate because of the limited capacity of ferrochelatase. Porphobilinogen deaminase (PBGD) is another enzyme that is active in the heme synthesis pathway (catalyzing the formation of uroporphyrinogen from porphobilinogen [PBG]). The activity of this enzyme is higher in some tumors (1-3), while that of ferrochelatase is lower (2-7), so that PpIX accumulates with some degree of selectivity in tumors. Because PpIX is an efficient photosensitizer, ALA has been introduced as a drug for clinical photodynamic therapy (PDT) of cancer (8,9). Photodynamic therapy involves systemic administration of a tumor-localizing photosensitizer and its subsequent activation by light of an appropriate wavelength to create a pho-" @default.
- W2739865720 created "2017-08-08" @default.
- W2739865720 creator A5024811171 @default.
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- W2739865720 date "1997-01-01" @default.
- W2739865720 modified "2023-10-09" @default.
- W2739865720 title "Invited Review 5-Aminolevulinic Acid-Based Photodynamic Therapy: Principles and Experimental Research" @default.
- W2739865720 cites W1485336339 @default.
- W2739865720 cites W1491111636 @default.
- W2739865720 cites W1497950363 @default.
- W2739865720 cites W1501964768 @default.
- W2739865720 cites W1506108633 @default.
- W2739865720 cites W1511974550 @default.
- W2739865720 cites W1512528704 @default.
- W2739865720 cites W1527389488 @default.
- W2739865720 cites W1532386728 @default.
- W2739865720 cites W1533177616 @default.
- W2739865720 cites W1536305347 @default.
- W2739865720 cites W1539124939 @default.
- W2739865720 cites W1542114776 @default.
- W2739865720 cites W1559821198 @default.
- W2739865720 cites W1575773639 @default.
- W2739865720 cites W1580686692 @default.
- W2739865720 cites W1585982112 @default.
- W2739865720 cites W1591909631 @default.
- W2739865720 cites W1593538558 @default.
- W2739865720 cites W1595620564 @default.
- W2739865720 cites W1610046461 @default.
- W2739865720 cites W1615838532 @default.
- W2739865720 cites W170823829 @default.
- W2739865720 cites W1767881325 @default.
- W2739865720 cites W1768641177 @default.
- W2739865720 cites W1856033583 @default.
- W2739865720 cites W1871616831 @default.
- W2739865720 cites W1948262976 @default.
- W2739865720 cites W1964219512 @default.
- W2739865720 cites W1965143896 @default.
- W2739865720 cites W1965378211 @default.
- W2739865720 cites W1966549695 @default.
- W2739865720 cites W1968424493 @default.
- W2739865720 cites W1968632600 @default.
- W2739865720 cites W1968774418 @default.
- W2739865720 cites W1968775497 @default.
- W2739865720 cites W1970614831 @default.
- W2739865720 cites W1971339390 @default.
- W2739865720 cites W1975464551 @default.
- W2739865720 cites W1976169837 @default.
- W2739865720 cites W1976565644 @default.
- W2739865720 cites W1976916629 @default.
- W2739865720 cites W1981427112 @default.
- W2739865720 cites W1983410310 @default.
- W2739865720 cites W1983747031 @default.
- W2739865720 cites W1984748335 @default.
- W2739865720 cites W1985585455 @default.
- W2739865720 cites W1985841747 @default.
- W2739865720 cites W1988274686 @default.
- W2739865720 cites W1990631978 @default.
- W2739865720 cites W1991152498 @default.
- W2739865720 cites W1992194919 @default.
- W2739865720 cites W1994202040 @default.
- W2739865720 cites W1994732126 @default.
- W2739865720 cites W1995681120 @default.
- W2739865720 cites W1997523883 @default.
- W2739865720 cites W1998125105 @default.
- W2739865720 cites W1998735492 @default.
- W2739865720 cites W1999475703 @default.
- W2739865720 cites W2001146803 @default.
- W2739865720 cites W2002246590 @default.
- W2739865720 cites W2003426797 @default.
- W2739865720 cites W2004791818 @default.
- W2739865720 cites W2010551500 @default.
- W2739865720 cites W2010946709 @default.
- W2739865720 cites W2011596779 @default.
- W2739865720 cites W2012619450 @default.
- W2739865720 cites W2013121231 @default.
- W2739865720 cites W2015238900 @default.
- W2739865720 cites W2015239304 @default.
- W2739865720 cites W2015534623 @default.
- W2739865720 cites W2016433896 @default.
- W2739865720 cites W2017363091 @default.
- W2739865720 cites W2019739499 @default.
- W2739865720 cites W2020249524 @default.
- W2739865720 cites W2020743781 @default.
- W2739865720 cites W2020799553 @default.
- W2739865720 cites W2021156022 @default.
- W2739865720 cites W2022350046 @default.
- W2739865720 cites W2022535035 @default.
- W2739865720 cites W2022805523 @default.
- W2739865720 cites W2023970032 @default.
- W2739865720 cites W2025855205 @default.
- W2739865720 cites W2027735936 @default.
- W2739865720 cites W2029328178 @default.
- W2739865720 cites W2032803546 @default.
- W2739865720 cites W2032831051 @default.
- W2739865720 cites W2033031329 @default.
- W2739865720 cites W2033853636 @default.
- W2739865720 cites W2039085306 @default.