Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739889625> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2739889625 endingPage "143" @default.
- W2739889625 startingPage "137" @default.
- W2739889625 abstract "Background & objectives: Recurrent spontaneous abortion (RSA) is defined by two or more consecutive miscarriages before 20 weeks of gestation. Adenos ine deaminase (ADA) is an enzyme of purine salvage pathway and has two important isoenzymes ADA1 and ADA2. The adenosine deaminase G22A polymorphism (ADA*2) increases the level of adenosine. Adenosine may play a protective role against recurrent spontaneou s abortions, since it regulates blood flow into the uterus and placenta. In consideration of the effect of decreased enzymatic activity of adenosine deaminase G22A polymorphism on adenosine levels we evaluated the protective effect of ADA*2 allele against recurrent spontaneous abortions in north-west of Iran. Methods: A total of 100 women were recruited to form two groups. First one, with a history of recurrent spontaneous abortions (N=50), and the second one, without a history of abortions (N=50). Genomic DNA was extracted from peripheral blood with a commercial kit and PCRRFLP analysis was used to identify the G22A genetic polymorphism. Fisher's exact test and odds ratio values were used to compare the proportions of adenosine deaminase genotypes and alleles between women with and without a history of recurrent spontaneous abortion (p<0.05). Results: The frequency of homozygotes (AA) was 2% in control group, whereas no homozygote (AA) was found in the case group. The frequency of heterozygotes (AG) was 20% in control group and 8% in the case group (p<0.05). The frequency of homozygotes (GG) was 78% in control group and 92% in the case group (p<0. 05). A significant increase in the frequency of AG genotype in controls (p=0.014, OR=0.348) relative to women with the history of RSA demonstrates the protective effect of AG genotype in controls. Conclusion: The data suggest that women carrying the G22A polymorphism (ADA*2 allele) and AG genotype which is associated with the lower enzymatic activity are better p rotected against recurrent spontaneous abortions." @default.
- W2739889625 created "2017-08-08" @default.
- W2739889625 creator A5005914583 @default.
- W2739889625 creator A5059835414 @default.
- W2739889625 creator A5070116259 @default.
- W2739889625 creator A5071024533 @default.
- W2739889625 date "2015-06-01" @default.
- W2739889625 modified "2023-09-26" @default.
- W2739889625 title "The ADA*2 Allele of the Adenosine Deaminase Gene and Recurrent Spontaneous Abortions in Northwest of Iran" @default.
- W2739889625 cites W1594087679 @default.
- W2739889625 cites W1981104128 @default.
- W2739889625 cites W1993000793 @default.
- W2739889625 cites W2004688598 @default.
- W2739889625 cites W2048122038 @default.
- W2739889625 cites W2075724668 @default.
- W2739889625 cites W2093452101 @default.
- W2739889625 cites W2109322628 @default.
- W2739889625 cites W2133914184 @default.
- W2739889625 cites W2153764364 @default.
- W2739889625 hasPublicationYear "2015" @default.
- W2739889625 type Work @default.
- W2739889625 sameAs 2739889625 @default.
- W2739889625 citedByCount "0" @default.
- W2739889625 crossrefType "journal-article" @default.
- W2739889625 hasAuthorship W2739889625A5005914583 @default.
- W2739889625 hasAuthorship W2739889625A5059835414 @default.
- W2739889625 hasAuthorship W2739889625A5070116259 @default.
- W2739889625 hasAuthorship W2739889625A5071024533 @default.
- W2739889625 hasConcept C104317684 @default.
- W2739889625 hasConcept C126322002 @default.
- W2739889625 hasConcept C135763542 @default.
- W2739889625 hasConcept C156957248 @default.
- W2739889625 hasConcept C180754005 @default.
- W2739889625 hasConcept C2776991684 @default.
- W2739889625 hasConcept C2778642596 @default.
- W2739889625 hasConcept C2779234561 @default.
- W2739889625 hasConcept C29456083 @default.
- W2739889625 hasConcept C34628245 @default.
- W2739889625 hasConcept C37463918 @default.
- W2739889625 hasConcept C54355233 @default.
- W2739889625 hasConcept C71924100 @default.
- W2739889625 hasConcept C86803240 @default.
- W2739889625 hasConceptScore W2739889625C104317684 @default.
- W2739889625 hasConceptScore W2739889625C126322002 @default.
- W2739889625 hasConceptScore W2739889625C135763542 @default.
- W2739889625 hasConceptScore W2739889625C156957248 @default.
- W2739889625 hasConceptScore W2739889625C180754005 @default.
- W2739889625 hasConceptScore W2739889625C2776991684 @default.
- W2739889625 hasConceptScore W2739889625C2778642596 @default.
- W2739889625 hasConceptScore W2739889625C2779234561 @default.
- W2739889625 hasConceptScore W2739889625C29456083 @default.
- W2739889625 hasConceptScore W2739889625C34628245 @default.
- W2739889625 hasConceptScore W2739889625C37463918 @default.
- W2739889625 hasConceptScore W2739889625C54355233 @default.
- W2739889625 hasConceptScore W2739889625C71924100 @default.
- W2739889625 hasConceptScore W2739889625C86803240 @default.
- W2739889625 hasIssue "2" @default.
- W2739889625 hasLocation W27398896251 @default.
- W2739889625 hasOpenAccess W2739889625 @default.
- W2739889625 hasPrimaryLocation W27398896251 @default.
- W2739889625 hasRelatedWork W1981029653 @default.
- W2739889625 hasRelatedWork W1981104128 @default.
- W2739889625 hasRelatedWork W2013703147 @default.
- W2739889625 hasRelatedWork W2014744825 @default.
- W2739889625 hasRelatedWork W2016414469 @default.
- W2739889625 hasRelatedWork W2037933908 @default.
- W2739889625 hasRelatedWork W2083625567 @default.
- W2739889625 hasRelatedWork W2089635780 @default.
- W2739889625 hasRelatedWork W2113198515 @default.
- W2739889625 hasRelatedWork W2352862138 @default.
- W2739889625 hasRelatedWork W2361550473 @default.
- W2739889625 hasRelatedWork W2381356272 @default.
- W2739889625 hasRelatedWork W2392750016 @default.
- W2739889625 hasRelatedWork W2549037934 @default.
- W2739889625 hasRelatedWork W2755757687 @default.
- W2739889625 hasRelatedWork W2966235625 @default.
- W2739889625 hasRelatedWork W3015737280 @default.
- W2739889625 hasRelatedWork W3152134536 @default.
- W2739889625 hasRelatedWork W3156973174 @default.
- W2739889625 hasRelatedWork W2189563042 @default.
- W2739889625 hasVolume "15" @default.
- W2739889625 isParatext "false" @default.
- W2739889625 isRetracted "false" @default.
- W2739889625 magId "2739889625" @default.
- W2739889625 workType "article" @default.