FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739900731> ?p ?o ?g. }

• W2739900731 endingPage "e0182061" @default.
• W2739900731 startingPage "e0182061" @default.
• W2739900731 abstract "Aldehyde oxidases (AOXs) are molybdo-flavoenzymes characterized by broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into the corresponding carboxylic acids and hydroxylating various heteroaromatic rings. The enzymes use oxygen as the terminal electron acceptor and produce reduced oxygen species during turnover. The physiological function of mammalian AOX isoenzymes is still unclear, however, human AOX (hAOX1) is an emerging enzyme in phase-I drug metabolism. Indeed, the number of xenobiotics acting as hAOX1 substrates is increasing. Further, numerous single-nucleotide polymorphisms (SNPs) have been identified within the hAOX1 gene. SNPs are a major source of inter-individual variability in the human population, and SNP-based amino acid exchanges in hAOX1 reportedly modulate the catalytic function of the enzyme in either a positive or negative fashion. In this report we selected ten novel SNPs resulting in amino acid exchanges in proximity to the FAD site of hAOX1 and characterized the purified enzymes after heterologous expression in Escherichia coli. The hAOX1 variants were characterized carefully by quantitative differences in their ability to produce superoxide radical. ROS represent prominent key molecules in physiological and pathological conditions in the cell. Our data reveal significant alterations in superoxide anion production among the variants. In particular the SNP-based amino acid exchange L438V in proximity to the isoalloxanzine ring of the FAD cofactor resulted in increased rate of superoxide radical production of 75%. Considering the high toxicity of the superoxide in the cell, the hAOX1-L438V SNP variant is an eventual candidate for critical or pathological roles of this natural variant within the human population." @default.
• W2739900731 created "2017-08-08" @default.
• W2739900731 creator A5040734620 @default.
• W2739900731 creator A5049387695 @default.
• W2739900731 creator A5058201313 @default.
• W2739900731 date "2017-07-27" @default.
• W2739900731 modified "2023-10-16" @default.
• W2739900731 title "A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase" @default.
• W2739900731 cites W1577554258 @default.
• W2739900731 cites W1965977591 @default.
• W2739900731 cites W1966948694 @default.
• W2739900731 cites W1991952977 @default.
• W2739900731 cites W2006136881 @default.
• W2739900731 cites W2007636933 @default.
• W2739900731 cites W2010803354 @default.
• W2739900731 cites W2011013568 @default.
• W2739900731 cites W2048397306 @default.
• W2739900731 cites W2051374865 @default.
• W2739900731 cites W2062112358 @default.
• W2739900731 cites W2068371198 @default.
• W2739900731 cites W2073711410 @default.
• W2739900731 cites W2084299658 @default.
• W2739900731 cites W2089065337 @default.
• W2739900731 cites W2091194381 @default.
• W2739900731 cites W2092178799 @default.
• W2739900731 cites W2107723834 @default.
• W2739900731 cites W2119073376 @default.
• W2739900731 cites W2124676097 @default.
• W2739900731 cites W2139819264 @default.
• W2739900731 cites W2156168853 @default.
• W2739900731 cites W2156294014 @default.
• W2739900731 cites W2233464627 @default.
• W2739900731 cites W2258998891 @default.
• W2739900731 cites W2290398427 @default.
• W2739900731 cites W2586371853 @default.
• W2739900731 cites W815720116 @default.
• W2739900731 cites W87483861 @default.
• W2739900731 doi "https://doi.org/10.1371/journal.pone.0182061" @default.
• W2739900731 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5531472" @default.
• W2739900731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28750088" @default.
• W2739900731 hasPublicationYear "2017" @default.
• W2739900731 type Work @default.
• W2739900731 sameAs 2739900731 @default.
• W2739900731 citedByCount "21" @default.
• W2739900731 countsByYear W27399007312018 @default.
• W2739900731 countsByYear W27399007312019 @default.
• W2739900731 countsByYear W27399007312020 @default.
• W2739900731 countsByYear W27399007312021 @default.
• W2739900731 countsByYear W27399007312022 @default.
• W2739900731 countsByYear W27399007312023 @default.
• W2739900731 crossrefType "journal-article" @default.
• W2739900731 hasAuthorship W2739900731A5040734620 @default.
• W2739900731 hasAuthorship W2739900731A5049387695 @default.
• W2739900731 hasAuthorship W2739900731A5058201313 @default.
• W2739900731 hasBestOaLocation W27399007311 @default.
• W2739900731 hasConcept C144024400 @default.
• W2739900731 hasConcept C149923435 @default.
• W2739900731 hasConcept C181199279 @default.
• W2739900731 hasConcept C185592680 @default.
• W2739900731 hasConcept C2778102346 @default.
• W2739900731 hasConcept C2779840689 @default.
• W2739900731 hasConcept C2780795997 @default.
• W2739900731 hasConcept C2908647359 @default.
• W2739900731 hasConcept C515207424 @default.
• W2739900731 hasConcept C55493867 @default.
• W2739900731 hasConcept C86803240 @default.
• W2739900731 hasConceptScore W2739900731C144024400 @default.
• W2739900731 hasConceptScore W2739900731C149923435 @default.
• W2739900731 hasConceptScore W2739900731C181199279 @default.
• W2739900731 hasConceptScore W2739900731C185592680 @default.
• W2739900731 hasConceptScore W2739900731C2778102346 @default.
• W2739900731 hasConceptScore W2739900731C2779840689 @default.
• W2739900731 hasConceptScore W2739900731C2780795997 @default.
• W2739900731 hasConceptScore W2739900731C2908647359 @default.
• W2739900731 hasConceptScore W2739900731C515207424 @default.
• W2739900731 hasConceptScore W2739900731C55493867 @default.
• W2739900731 hasConceptScore W2739900731C86803240 @default.
• W2739900731 hasFunder F4320320879 @default.
• W2739900731 hasIssue "7" @default.
• W2739900731 hasLocation W27399007311 @default.
• W2739900731 hasLocation W27399007312 @default.
• W2739900731 hasLocation W27399007313 @default.
• W2739900731 hasLocation W27399007314 @default.
• W2739900731 hasOpenAccess W2739900731 @default.
• W2739900731 hasPrimaryLocation W27399007311 @default.
• W2739900731 hasRelatedWork W1509077075 @default.
• W2739900731 hasRelatedWork W1644178486 @default.
• W2739900731 hasRelatedWork W1970913536 @default.
• W2739900731 hasRelatedWork W1998894350 @default.
• W2739900731 hasRelatedWork W2037157726 @default.
• W2739900731 hasRelatedWork W2046360546 @default.
• W2739900731 hasRelatedWork W2051208451 @default.
• W2739900731 hasRelatedWork W2058342217 @default.
• W2739900731 hasRelatedWork W2147934559 @default.
• W2739900731 hasRelatedWork W2166290675 @default.
• W2739900731 hasVolume "12" @default.
• W2739900731 isParatext "false" @default.
• W2739900731 isRetracted "false" @default.

• next