FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739905384> ?p ?o ?g. }

• W2739905384 endingPage "1285" @default.
• W2739905384 startingPage "1285" @default.
• W2739905384 abstract "Fisetin is a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions. Since fisetin can elicit anti-cancer effects, including anti-proliferation and anti-migration, we investigated whether fisetin induced apoptosis in human renal carcinoma (Caki) cells. Fisetin markedly induced sub-G1 population and cleavage of poly (ADP-ribose) polymerase (PARP), which is a marker of apoptosis, and increased caspase activation. We found that pan-caspase inhibitor (z-VAD-fmk) inhibited fisetin-induced apoptosis. In addition, fisetin induced death receptor 5 (DR5) expression at the transcriptional level, and down-regulation of DR5 by siRNA blocked fisetin-induced apoptosis. Furthermore, fisetin induced p53 protein expression through up-regulation of protein stability, whereas down-regulation of p53 by siRNA markedly inhibited fisetin-induced DR5 expression. In contrast, fisetin induced up-regulation of CHOP expression and reactive oxygen species production, which had no effect on fisetin-induced apoptosis. Taken together, our study demonstrates that fisetin induced apoptosis through p53 mediated up-regulation of DR5 expression at the transcriptional level." @default.
• W2739905384 created "2017-08-08" @default.
• W2739905384 creator A5023771868 @default.
• W2739905384 creator A5054495808 @default.
• W2739905384 creator A5070789043 @default.
• W2739905384 date "2017-08-02" @default.
• W2739905384 modified "2023-10-16" @default.
• W2739905384 title "Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells" @default.
• W2739905384 cites W127577078 @default.
• W2739905384 cites W1514262699 @default.
• W2739905384 cites W1602745681 @default.
• W2739905384 cites W1965727325 @default.
• W2739905384 cites W1993334239 @default.
• W2739905384 cites W2005961282 @default.
• W2739905384 cites W2012135587 @default.
• W2739905384 cites W2031293873 @default.
• W2739905384 cites W2034427923 @default.
• W2739905384 cites W2035222913 @default.
• W2739905384 cites W2053301688 @default.
• W2739905384 cites W2053758678 @default.
• W2739905384 cites W2078016121 @default.
• W2739905384 cites W2084733813 @default.
• W2739905384 cites W2087096438 @default.
• W2739905384 cites W2099104753 @default.
• W2739905384 cites W2110387748 @default.
• W2739905384 cites W2110577324 @default.
• W2739905384 cites W2111871108 @default.
• W2739905384 cites W2117078917 @default.
• W2739905384 cites W2120036274 @default.
• W2739905384 cites W2124992697 @default.
• W2739905384 cites W2131333100 @default.
• W2739905384 cites W2147327518 @default.
• W2739905384 cites W2172627012 @default.
• W2739905384 cites W2276027104 @default.
• W2739905384 cites W2353530036 @default.
• W2739905384 cites W2411745766 @default.
• W2739905384 cites W2529653456 @default.
• W2739905384 cites W2545444420 @default.
• W2739905384 cites W2570928071 @default.
• W2739905384 cites W2586935452 @default.
• W2739905384 cites W2735460229 @default.
• W2739905384 doi "https://doi.org/10.3390/molecules22081285" @default.
• W2739905384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6151974" @default.
• W2739905384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28767099" @default.
• W2739905384 hasPublicationYear "2017" @default.
• W2739905384 type Work @default.
• W2739905384 sameAs 2739905384 @default.
• W2739905384 citedByCount "32" @default.
• W2739905384 countsByYear W27399053842017 @default.
• W2739905384 countsByYear W27399053842018 @default.
• W2739905384 countsByYear W27399053842019 @default.
• W2739905384 countsByYear W27399053842020 @default.
• W2739905384 countsByYear W27399053842021 @default.
• W2739905384 countsByYear W27399053842022 @default.
• W2739905384 countsByYear W27399053842023 @default.
• W2739905384 crossrefType "journal-article" @default.
• W2739905384 hasAuthorship W2739905384A5023771868 @default.
• W2739905384 hasAuthorship W2739905384A5054495808 @default.
• W2739905384 hasAuthorship W2739905384A5070789043 @default.
• W2739905384 hasBestOaLocation W27399053841 @default.
• W2739905384 hasConcept C104317684 @default.
• W2739905384 hasConcept C182979987 @default.
• W2739905384 hasConcept C185592680 @default.
• W2739905384 hasConcept C190283241 @default.
• W2739905384 hasConcept C2777376040 @default.
• W2739905384 hasConcept C2778004101 @default.
• W2739905384 hasConcept C2779054382 @default.
• W2739905384 hasConcept C502942594 @default.
• W2739905384 hasConcept C55493867 @default.
• W2739905384 hasConcept C82381507 @default.
• W2739905384 hasConcept C86803240 @default.
• W2739905384 hasConcept C95444343 @default.
• W2739905384 hasConceptScore W2739905384C104317684 @default.
• W2739905384 hasConceptScore W2739905384C182979987 @default.
• W2739905384 hasConceptScore W2739905384C185592680 @default.
• W2739905384 hasConceptScore W2739905384C190283241 @default.
• W2739905384 hasConceptScore W2739905384C2777376040 @default.
• W2739905384 hasConceptScore W2739905384C2778004101 @default.
• W2739905384 hasConceptScore W2739905384C2779054382 @default.
• W2739905384 hasConceptScore W2739905384C502942594 @default.
• W2739905384 hasConceptScore W2739905384C55493867 @default.
• W2739905384 hasConceptScore W2739905384C82381507 @default.
• W2739905384 hasConceptScore W2739905384C86803240 @default.
• W2739905384 hasConceptScore W2739905384C95444343 @default.
• W2739905384 hasIssue "8" @default.
• W2739905384 hasLocation W27399053841 @default.
• W2739905384 hasLocation W27399053842 @default.
• W2739905384 hasLocation W27399053843 @default.
• W2739905384 hasLocation W27399053844 @default.
• W2739905384 hasLocation W27399053845 @default.
• W2739905384 hasOpenAccess W2739905384 @default.
• W2739905384 hasPrimaryLocation W27399053841 @default.
• W2739905384 hasRelatedWork W1827837756 @default.
• W2739905384 hasRelatedWork W1989604654 @default.
• W2739905384 hasRelatedWork W2013803620 @default.
• W2739905384 hasRelatedWork W2352522081 @default.
• W2739905384 hasRelatedWork W2367566516 @default.
• W2739905384 hasRelatedWork W2390011030 @default.

• next