Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739940804> ?p ?o ?g. }
- W2739940804 abstract "A more effective approach to the surveillance and prevention of esophageal adenocarcinoma, one of the most lethal of all cancers, is urgently needed. Little progress has been made in the treatment of patients who present with symptoms of obstructive and invasive cancer. The incidence of this cancer is increasing in epidemic proportions throughout the United States and the Western world.7, s, 17, 26, 28, 70, 132, 133 This increase is almost entirely due to carcinomas arising in an easily recognizable precancerous lesion-Barrett’s metaplasia. Progression from metaplasia to invasive cancer occurs in a stepwise process that can be recognized through endoscopic biopsy. For reasons that are as yet unresolved, this cancer develops in a select population of patients. The rapid increase in the incidence of this cancer in a select group of patients over a relatively short duration of time strongly suggests that environmental factors interacting with genetically predetermined characteristics are the cause for this neoplastic epidemic. Further studies are needed to identify risk factors and cost-effective surveillance strategies that can prevent this cancer progression. Patients with Barrett’s metaplasia carry an increased risk for the development of esophageal adenocarcinoma that is 30 to 125 times that of an age-matched population. It has been estimated that 700,000 to 1.5 million Americans have Barrett’s metaplasia. The incidence of adenocarcinoma has been dramatically increasing over the last 3 decades. Nearly" @default.
- W2739940804 created "2017-08-08" @default.
- W2739940804 creator A5007449469 @default.
- W2739940804 creator A5031777285 @default.
- W2739940804 creator A5068647255 @default.
- W2739940804 creator A5085314655 @default.
- W2739940804 date "1999-01-01" @default.
- W2739940804 modified "2023-09-27" @default.
- W2739940804 title "Reducing the Risk of Progression to Adenocarcinoma" @default.
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