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• W2739969368 abstract "The aim of the present study was to examine the effect of extracellular heat shock protein (HSP) 72 on human periodontal ligament fibroblast cells (hPDLFs) in vitro.hPDLFs were stimulated by recombinant human HSP72 (rhHSP72). TAK-242 was used to inhibit toll-like receptor 4 (TLR4) activity. Interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α mRNA levels were analyzed by real-time PCR and protein levels were analyzed by enzyme-linked immunosorbent assay. p65/RelA phosphorylation was analyzed by western blot.IL-6, IL-8 and TNF-α mRNA and protein levels were significantly increased by rhHSP72 stimulation. These effects were inhibited by TAK-242 treatment. Additionally, p65/RelA phosphorylation was increased after 5-min rhHSP72 stimulation, which was inhibited by TAK-242 treatment.Extracellular HSP72 induces proinflammatory cytokines through TLR4/NF-κB in hPDLFs." @default.
• W2739969368 created "2017-08-08" @default.
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• W2739969368 date "2017-11-01" @default.
• W2739969368 modified "2023-10-10" @default.
• W2739969368 title "Extracellular HSP72 induces proinflammatory cytokines in human periodontal ligament fibroblast cells through the TLR4/NFκB pathway in vitro" @default.
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• W2739969368 doi "https://doi.org/10.1016/j.archoralbio.2017.07.021" @default.
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