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• W2740027364 abstract "The intrarenal autocrine-paracrine dopamine (DA) system mediates a significant fraction of the natriuresis in response to a salt load. DA inhibits a number of Na + transporters to effect sodium excretion, including the proximal tubule Na + /H + exchanger-3 (NHE3). DA represent a single hormone that regulates NHE3 at multiple levels, including translation, degradation, endocytosis, and protein phosphorylation. Because cell surface NHE3 protein is determined by the balance between exocytotic insertion and endocytotic retrieval, we examined whether DA acutely affects the rate of NHE3 exocytosis in a cell culture model. DA inhibited NHE3 exocytosis at a dose-dependent manner with a half maximal around 10 −6 M. The DA effect on NHE3 exocytosis was blocked by inhibition of protein kinase A and by brefeldin A, which inhibits endoplasmic reticulum-to-Golgi transport. NHE3 directly interacts with the ε-subunit of coatomer protein based on yeast-two-hybrid and coimmunoprecipitation. Because NHE3 has been shown to be recycled back to the cell membrane after endocytosis, we measured NHE3 recycling using a biochemical reinsertion assay and showed that reinsertion of NHE3 back to the membrane is also inhibited by DA. In conclusion, among the many mechanisms by which DA reduces apical membrane NHE3 and induces proximal tubule natriuresis, one additional mechanism is inhibition of exocytotic insertion and reinsertion of NHE3 in the apical cell surface." @default.
• W2740027364 created "2017-08-08" @default.
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• W2740027364 date "2017-10-01" @default.
• W2740027364 modified "2023-10-18" @default.
• W2740027364 title "Dopamine reduces cell surface Na⁺/H⁺exchanger-3 protein by decreasing NHE3 exocytosis and cell membrane recycling" @default.
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• W2740027364 cites W1978197073 @default.
• W2740027364 cites W1993197897 @default.
• W2740027364 cites W1994055882 @default.
• W2740027364 cites W1994404529 @default.
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• W2740027364 doi "https://doi.org/10.1152/ajprenal.00251.2017" @default.
• W2740027364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5668584" @default.
• W2740027364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28768665" @default.
• W2740027364 hasPublicationYear "2017" @default.
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