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• W2740046747 abstract "Deep Brain Stimulation: Technology and Applications (Volume 1) Closed-loop programming: animal studiesHagai Bergman, Zvi Israel & Boris RosinHagai BergmanHagai Bergman completed his postdoctorate fellowships with Moshe Abeles (Hebrew University of Jerusalem, Israel) and Mahlon DeLong (John Hopkins Medical School, MD, USA). He has worked in the Department of Physiology at the Hebrew University – Hadassah Medical School (Jerusalem, Israel) since 1990, where he was appointed as the Simone and Bernard Guttman Chair in Brain Research in 1993 and as a full Professor in 2004.Search for more papers by this author, Zvi IsraelZvi Israel is Senior Lecturer in Neurosurgery at Hadassah University Hospital (Jerusalem, Israel). He trained in functional neurosurgery with Kim Burchiel at Oregon Health and Sciences University (OR, USA). Since 2001, he has directed the functional neurosurgery unit at Hadassah University Hospital.Search for more papers by this author & Boris RosinBoris Rosin has recently completed his PhD studies in the laboratory of Hagai Bergman. In 2013, he commenced his MD residency at the Department of Ophthalmology, Hadassah and Hebrew University Medical Center. There, he is involved in research of retinal electrophysiology in health and disease and explores the interrelation of the basal ganglia and the visual system.Search for more papers by this authorPublished Online:25 Aug 2014https://doi.org/10.2217/ebo.12.505AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInReddit View chapterAbstract: In this chapter, we will briefly review the main animal models of Parkinson’s disease (PD) and their role in the development of deep brain stimulation (DBS) surgery in human PD patients. Subsequently, we will discuss the notion of closed-loop DBS, already defined in Chapter 5, presenting results from animal studies. Finally, we will identify some possible strategies for closing the DBS loop, discuss the challenges of migrating animal model systems to human PD patients and outline future goals of animal and human closed-loop DBS research. References1 Bechtereva NP , Bondartchuk AN , Smirnov VM , Meliutcheva LA , Shandurina AN . Method of electrostimulation of the deep brain structures in treatment of some chronic diseases . Confin. Neurol. 37 (1–3) , 136 – 140 (1975) . Crossref, Medline, CAS, Google Scholar2 Hassler R , Riechert T . Symptomatology and surgery of extrapyramidal movement disorders . Med. Klin. (Munich) 53 (19) , 817 – 824 (1958) . Medline, CAS, Google Scholar3 Hariz MI , Blomstedt P , Zrinzo L . Deep brain stimulation between 1947 and 1987: the untold story . Neurosurg. Focus 29 (2) , E1 (2010) . Crossref, Medline, Google Scholar4 Cotzias GC . 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