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- W2740065210 abstract "Most of natural products, such as, medicinal plants and herbs confer protective effects against a wide range of cancers, including colon cancer. Cichorium endivia, L. has been shown to have anti-inflammatory and antioxidant properties. Thirty two male mice were divided into four groups. Group I served as control. Groups 2, 3 and 4 were administered freshly prepared DMH for three weeks, twice per week. Group 3 received the anticancer drug 5 FU for two weeks. Half of this group was sacrificed after 2 weeks while the other half continued until the experiment ended. Group 4 received the plant extract which was divided into 3 sub-groups. Each sub group was administered with a different concentration of the extract (200-400-600 mg/kg bodyweight/ day) for 40 days. Animals were sacrificed; blood was collected and the colons were subjected for investigation. P53 expression was nearly the same in both control and all treated tissues. BCl 2 expression decreased in mice treated with 5FU and specifically with Cichorium. TNF- expression was lower in tissues treated with 5FU compared with the control. Meanwhile, the expression of dose 200 mg/kg.b.wt, was lower than both the control and the 5FU treated tissues. The real time PCR analysis of blood samples showed that the expression of interleukin IL-12 and IL-4 was higher in blood cells treated with plant extract compared with the 5 FU. The two effective doses were 200 and 600 mg/kg.b.wt. In contrast, therapeutic treatments mute the expression of interferon IFN marker. It is thus concluded that, Cichorium endivia, especially dose 200 mg/ kg.b.wt., represents an effective anticancer and immune response drug especially for colon cancer." @default.
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- W2740065210 date "2014-01-01" @default.
- W2740065210 modified "2023-09-27" @default.
- W2740065210 title "EXPRESSION OF TUMOR-MARKERS AND CYTOKINES IN RESPONSE TO CICHORIUM ENDIVIA L. IN CANCEROUS MICE" @default.
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