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- W2740129154 abstract "SUMMARY A neutralizing monoclonal antibody (nmAb) tofoot-and-mouth disease virus (FMDV)was usedas antibody-I (ABI) toinduce anti-idiotypic antibodies (a-IdAb) inrabbits. Therabbit a-IdAb(AB2) were isolated on protein A-Sepharose, followed bycycles ofseparation on idiotype andisotype affinity columns. Thespecificity oftheAB2fortheparatope ofABIwasdetermined bydirect binding toABIinsolid-phase radioimmunoassay (SP-RIA), andbycompetition RIA(C-RIA) withvirus for binding totheAB1.TheAB2,termed a-2PDI 1,was utilized toimmunize six groupsoffemale Swiss miceatweekly intervals witheither oneofthree formulations, indoses of50ugor5yg,given insingle subcutaneous (s.c.) spots. Anti-viral antibody (AB3) wasfirst detected byRIAatthefifth weekinthe 50pg/dose groups,andmaximumlevels were reached atthesixth weekinthe50and5 pg/dose groups.TheAB3levels wereatleast three times higher formicegiven 50pgdoses. Inaddition, the AB3were alsoshowntoneutralize FMDV infectivity intissue culture andina suckling mouse protection assay.Overall, miceexhibited variable responsestoimmunization withAB2.Ina subsequent trial, micereceived multispot s.c.andfootpad injections of50pgofa-2PD1Icoupled to keyhole limpet haemocyanin (KLH)on aweekly basis. Inthese mice, AB3was detected earlier than inmiceimmunized withsingle s.c.injections. Theseresults support theuseofa-IdAb aspotential surrogates ofcritical determinants forFMD vaccines." @default.
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- W2740129154 date "1989-01-01" @default.
- W2740129154 modified "2023-09-23" @default.
- W2740129154 title "antibodies induced in micebyanti-idiotypic antibodies" @default.
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