FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740129689> ?p ?o ?g. }

• W2740129689 endingPage "543" @default.
• W2740129689 startingPage "541" @default.
• W2740129689 abstract "The diagnostic and prognostic values of stress myocardial perfusion imaging (MPI) is well established with SPECT and more recently with PET or PET-CT imaging. Conventional MPI identifies local reductions in perfusion relative to the best ventricular wall, where the maximum value is presumed to be normal. However, this technique is known to underestimate the extent or severity of multi-vessel coronary disease, when the maximum value does not represent normally perfused myocardium. In contrast, myocardial perfusion measured on an absolute scale (mL/min/g) permits the assessment of stress-to-rest perfusion or vasodilator reserve without the assumption of a normal reference region, first demonstrated with PET imaging by Gould et al In this way, the stress perfusion scan is interpreted relative to the individual’s normal resting state, using the patient as their own control. The clinical value of absolute perfusion or myocardial blood flow (MBF) measurements has been reported extensively using dynamic PET imaging with O-water and Nammonia in patient populations such as diabetes, hypertension, hyperlipidemia, smoking, syndrome X, non-compaction, takotsubo, hypertrophic ,and dilated cardiomyopathies. The impact of invasive fractional flow reserve (FFR) imaging to direct PCI and improve patient outcome has recently been reported using FFR measurements in a prospective randomized controlled trial. However, there is limited data available on the value of non-invasive myocardial flow reserve (MFR) imaging to improve patient management, or predict future clinical events, compared to conventional MPI. This is partly due to the limited availability of Nammonia and O-water PET, which require a local cyclotron for tracer production. Tio et al recently reported on the prognostic value of N-ammonia PET flow reserve imaging in patients with known coronary artery disease and LV dysfunction who did not undergo revascularization. This study showed that MFR was a stronger predictor of cardiac death compared to LVEF in this population (HR 4.1 vs 2.8; 7 years median followup), but did not assess the incremental value compared to standard MPI. Herzog demonstrated similar findings that impaired MFR (ratio 2) was an independent predictor of cardiac death (HR 2.9; 5.5 years mean follow-up) using N-ammonia PET in a wider unselected population. This study also showed the incremental prognostic value of MFR over standard MPI in patients with known or suspected CAD, more typical of the clinical population referred for assessment of myocardial ischemia. In patients with normal MPI, impaired MFR was an independent predictor of cardiac death (3.1 vs 0.5%) and major adverse cardiac events (MACE; 6.3 vs 1.4%) within a period of 3 years. In patients with abnormal MPI, impaired MFR also predicted an increased rate of disease progression, even beyond 3 years. A larger patient series, followed for a shorter time, has recently confirmed the incremental prognostic value of generator-produced Rb PET MFR to predict death or myocardial infarction (death ? MI; HR C 3.3) and MACE (HR C 2.4; 1-year median follow-up) in patients with normal or abnormal stress MPI. The current study by Stephania et al builds on these previous findings using Tc-SPECT, which is more widely available as the clinical standard for MPI. The authors use first-pass planar imaging followed by conventional SPECT MPI to estimate a retention index of MBF and corresponding global flow reserve. They From the Division of Cardiology, Cardiac Imaging, The National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada. Reprint requests: Robert A. deKemp, PhD, Cardiac Imaging, The National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada; radekemp@ ottawaheart.ca. J Nucl Cardiol 2011;18:541–3. 1071-3581/$34.00 Copyright 2011 American Society of Nuclear Cardiology. doi:10.1007/s12350-011-9408-6" @default.
• W2740129689 created "2017-08-08" @default.
• W2740129689 creator A5045662256 @default.
• W2740129689 creator A5050890781 @default.
• W2740129689 creator A5056264770 @default.
• W2740129689 date "2011-06-14" @default.
• W2740129689 modified "2023-09-25" @default.
• W2740129689 title "Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography" @default.
• W2740129689 cites W1602983020 @default.
• W2740129689 cites W1966751875 @default.
• W2740129689 cites W1980156542 @default.
• W2740129689 cites W1983488763 @default.
• W2740129689 cites W2002907367 @default.
• W2740129689 cites W2008121884 @default.
• W2740129689 cites W2014184577 @default.
• W2740129689 cites W2016902413 @default.
• W2740129689 cites W2024053942 @default.
• W2740129689 cites W2024951927 @default.
• W2740129689 cites W2026346501 @default.
• W2740129689 cites W2036442606 @default.
• W2740129689 cites W2038920648 @default.
• W2740129689 cites W2068354665 @default.
• W2740129689 cites W2074251522 @default.
• W2740129689 cites W2087282394 @default.
• W2740129689 cites W2094078131 @default.
• W2740129689 cites W2102612506 @default.
• W2740129689 cites W2103369597 @default.
• W2740129689 cites W2110603576 @default.
• W2740129689 cites W2113298000 @default.
• W2740129689 cites W2115416118 @default.
• W2740129689 doi "https://doi.org/10.1007/s12350-011-9408-6" @default.
• W2740129689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21671147" @default.
• W2740129689 hasPublicationYear "2011" @default.
• W2740129689 type Work @default.
• W2740129689 sameAs 2740129689 @default.
• W2740129689 citedByCount "2" @default.
• W2740129689 countsByYear W27401296892014 @default.
• W2740129689 crossrefType "journal-article" @default.
• W2740129689 hasAuthorship W2740129689A5045662256 @default.
• W2740129689 hasAuthorship W2740129689A5050890781 @default.
• W2740129689 hasAuthorship W2740129689A5056264770 @default.
• W2740129689 hasBestOaLocation W27401296891 @default.
• W2740129689 hasConcept C105795698 @default.
• W2740129689 hasConcept C126322002 @default.
• W2740129689 hasConcept C126838900 @default.
• W2740129689 hasConcept C164705383 @default.
• W2740129689 hasConcept C2775842073 @default.
• W2740129689 hasConcept C2776291640 @default.
• W2740129689 hasConcept C2777987666 @default.
• W2740129689 hasConcept C2778064278 @default.
• W2740129689 hasConcept C2778213512 @default.
• W2740129689 hasConcept C2778707443 @default.
• W2740129689 hasConcept C2780441642 @default.
• W2740129689 hasConcept C2989005 @default.
• W2740129689 hasConcept C3019004856 @default.
• W2740129689 hasConcept C33923547 @default.
• W2740129689 hasConcept C500558357 @default.
• W2740129689 hasConcept C544519230 @default.
• W2740129689 hasConcept C71924100 @default.
• W2740129689 hasConceptScore W2740129689C105795698 @default.
• W2740129689 hasConceptScore W2740129689C126322002 @default.
• W2740129689 hasConceptScore W2740129689C126838900 @default.
• W2740129689 hasConceptScore W2740129689C164705383 @default.
• W2740129689 hasConceptScore W2740129689C2775842073 @default.
• W2740129689 hasConceptScore W2740129689C2776291640 @default.
• W2740129689 hasConceptScore W2740129689C2777987666 @default.
• W2740129689 hasConceptScore W2740129689C2778064278 @default.
• W2740129689 hasConceptScore W2740129689C2778213512 @default.
• W2740129689 hasConceptScore W2740129689C2778707443 @default.
• W2740129689 hasConceptScore W2740129689C2780441642 @default.
• W2740129689 hasConceptScore W2740129689C2989005 @default.
• W2740129689 hasConceptScore W2740129689C3019004856 @default.
• W2740129689 hasConceptScore W2740129689C33923547 @default.
• W2740129689 hasConceptScore W2740129689C500558357 @default.
• W2740129689 hasConceptScore W2740129689C544519230 @default.
• W2740129689 hasConceptScore W2740129689C71924100 @default.
• W2740129689 hasIssue "4" @default.
• W2740129689 hasLocation W27401296891 @default.
• W2740129689 hasLocation W27401296892 @default.
• W2740129689 hasOpenAccess W2740129689 @default.
• W2740129689 hasPrimaryLocation W27401296891 @default.
• W2740129689 hasRelatedWork W1969670938 @default.
• W2740129689 hasRelatedWork W2030442274 @default.
• W2740129689 hasRelatedWork W2048454723 @default.
• W2740129689 hasRelatedWork W2129028760 @default.
• W2740129689 hasRelatedWork W2130856145 @default.
• W2740129689 hasRelatedWork W2156837964 @default.
• W2740129689 hasRelatedWork W2417317414 @default.
• W2740129689 hasRelatedWork W2551171865 @default.
• W2740129689 hasRelatedWork W3035122640 @default.
• W2740129689 hasRelatedWork W3213311516 @default.
• W2740129689 hasVolume "18" @default.
• W2740129689 isParatext "false" @default.
• W2740129689 isRetracted "false" @default.
• W2740129689 magId "2740129689" @default.
• W2740129689 workType "article" @default.