Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740137483> ?p ?o ?g. }
- W2740137483 endingPage "e0182032" @default.
- W2740137483 startingPage "e0182032" @default.
- W2740137483 abstract "Although it is not yet possible to replace in vivo animal testing completely, the need for a more efficient method for toxicity testing, such as an in vitro cell-based assay, has been widely acknowledged. Previous studies have focused on mRNAs as biomarkers; however, recent studies have revealed that non-coding RNAs (ncRNAs) are also efficient novel biomarkers for toxicity testing. Here, we used deep sequencing analysis (RNA-seq) to identify novel RNA biomarkers, including ncRNAs, that exhibited a substantial response to general chemical toxicity from nine chemicals, and to benzene toxicity specifically. The nine chemicals are listed in the Japan Pollutant Release and Transfer Register as class I designated chemical substances. We used undifferentiated mouse embryonic stem cells (mESCs) as a simplified cell-based toxicity assay. RNA-seq revealed that many mRNAs and ncRNAs responded substantially to the chemical compounds in mESCs. This finding indicates that ncRNAs can be used as novel RNA biomarkers for chemical safety screening." @default.
- W2740137483 created "2017-08-08" @default.
- W2740137483 creator A5006511872 @default.
- W2740137483 creator A5027187360 @default.
- W2740137483 creator A5029349474 @default.
- W2740137483 creator A5033476836 @default.
- W2740137483 creator A5043237109 @default.
- W2740137483 creator A5054937090 @default.
- W2740137483 creator A5057153302 @default.
- W2740137483 creator A5070145228 @default.
- W2740137483 creator A5079140540 @default.
- W2740137483 creator A5079605823 @default.
- W2740137483 creator A5081404038 @default.
- W2740137483 date "2017-07-27" @default.
- W2740137483 modified "2023-09-24" @default.
- W2740137483 title "Identification of RNA biomarkers for chemical safety screening in mouse embryonic stem cells using RNA deep sequencing analysis" @default.
- W2740137483 cites W1902917012 @default.
- W2740137483 cites W1969392349 @default.
- W2740137483 cites W1970285719 @default.
- W2740137483 cites W1972922971 @default.
- W2740137483 cites W1973012811 @default.
- W2740137483 cites W1975216365 @default.
- W2740137483 cites W1978967539 @default.
- W2740137483 cites W2000068256 @default.
- W2740137483 cites W2006820294 @default.
- W2740137483 cites W2008446011 @default.
- W2740137483 cites W2012021122 @default.
- W2740137483 cites W2039054570 @default.
- W2740137483 cites W2039478382 @default.
- W2740137483 cites W2043777033 @default.
- W2740137483 cites W2062118486 @default.
- W2740137483 cites W2068927083 @default.
- W2740137483 cites W2088653389 @default.
- W2740137483 cites W2091161969 @default.
- W2740137483 cites W2091816920 @default.
- W2740137483 cites W2096525273 @default.
- W2740137483 cites W2097625004 @default.
- W2740137483 cites W2103230738 @default.
- W2740137483 cites W2116593863 @default.
- W2740137483 cites W2134907537 @default.
- W2740137483 cites W2149146453 @default.
- W2740137483 cites W2164421534 @default.
- W2740137483 cites W2297248274 @default.
- W2740137483 cites W2316375341 @default.
- W2740137483 cites W2469164574 @default.
- W2740137483 cites W2483412115 @default.
- W2740137483 cites W4231041617 @default.
- W2740137483 cites W644986298 @default.
- W2740137483 doi "https://doi.org/10.1371/journal.pone.0182032" @default.
- W2740137483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5531504" @default.
- W2740137483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28750099" @default.
- W2740137483 hasPublicationYear "2017" @default.
- W2740137483 type Work @default.
- W2740137483 sameAs 2740137483 @default.
- W2740137483 citedByCount "6" @default.
- W2740137483 countsByYear W27401374832019 @default.
- W2740137483 countsByYear W27401374832020 @default.
- W2740137483 countsByYear W27401374832023 @default.
- W2740137483 crossrefType "journal-article" @default.
- W2740137483 hasAuthorship W2740137483A5006511872 @default.
- W2740137483 hasAuthorship W2740137483A5027187360 @default.
- W2740137483 hasAuthorship W2740137483A5029349474 @default.
- W2740137483 hasAuthorship W2740137483A5033476836 @default.
- W2740137483 hasAuthorship W2740137483A5043237109 @default.
- W2740137483 hasAuthorship W2740137483A5054937090 @default.
- W2740137483 hasAuthorship W2740137483A5057153302 @default.
- W2740137483 hasAuthorship W2740137483A5070145228 @default.
- W2740137483 hasAuthorship W2740137483A5079140540 @default.
- W2740137483 hasAuthorship W2740137483A5079605823 @default.
- W2740137483 hasAuthorship W2740137483A5081404038 @default.
- W2740137483 hasBestOaLocation W27401374831 @default.
- W2740137483 hasConcept C104317684 @default.
- W2740137483 hasConcept C145059251 @default.
- W2740137483 hasConcept C145103041 @default.
- W2740137483 hasConcept C178790620 @default.
- W2740137483 hasConcept C185592680 @default.
- W2740137483 hasConcept C194993378 @default.
- W2740137483 hasConcept C29730261 @default.
- W2740137483 hasConcept C54355233 @default.
- W2740137483 hasConcept C67705224 @default.
- W2740137483 hasConcept C70721500 @default.
- W2740137483 hasConcept C86803240 @default.
- W2740137483 hasConceptScore W2740137483C104317684 @default.
- W2740137483 hasConceptScore W2740137483C145059251 @default.
- W2740137483 hasConceptScore W2740137483C145103041 @default.
- W2740137483 hasConceptScore W2740137483C178790620 @default.
- W2740137483 hasConceptScore W2740137483C185592680 @default.
- W2740137483 hasConceptScore W2740137483C194993378 @default.
- W2740137483 hasConceptScore W2740137483C29730261 @default.
- W2740137483 hasConceptScore W2740137483C54355233 @default.
- W2740137483 hasConceptScore W2740137483C67705224 @default.
- W2740137483 hasConceptScore W2740137483C70721500 @default.
- W2740137483 hasConceptScore W2740137483C86803240 @default.
- W2740137483 hasIssue "7" @default.
- W2740137483 hasLocation W27401374831 @default.
- W2740137483 hasLocation W27401374832 @default.
- W2740137483 hasLocation W27401374833 @default.
- W2740137483 hasLocation W27401374834 @default.