FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740137536> ?p ?o ?g. }

• W2740137536 endingPage "741" @default.
• W2740137536 startingPage "728" @default.
• W2740137536 abstract "Pw1 gene expression is a marker of adult stem cells in a wide range of tissues. PW1-expressing cells are detected in the heart but are not well characterized.The authors characterized cardiac PW1-expressing cells and their cell fate potentials in normal hearts and during cardiac remodeling following myocardial infarction (MI).A human cardiac sample was obtained from a patient presenting with reduced left ventricular (LV) function following a recent MI. The authors used the PW1nLacZ+/- reporter mouse to identify, track, isolate, and characterize PW1-expressing cells in the LV myocardium in normal and ischemic conditions 7 days after complete ligature of the left anterior descending coronary artery.In both human and mouse ischemic hearts, PW1 expression was found in cells that were mainly located in the infarct and border zones. Isolated cardiac resident PW1+ cells form colonies and have the potential to differentiate into multiple cardiac and mesenchymal lineages, with preferential differentiation into fibroblast-like cells but not into cardiomyocytes. Lineage-tracing experiments revealed that PW1+ cells differentiated into fibroblasts post-MI. Although the expression of c-Kit and PW1 showed little overlap in normal hearts, a marked increase in cells coexpressing both markers was observed in ischemic hearts (0.1 ± 0.0% in control vs. 5.7 ± 1.2% in MI; p < 0.001). In contrast to the small proportion of c-Kit+/PW1- cells that showed cardiogenic potential, c-Kit+/PW1+ cells were fibrogenic.This study demonstrated the existence of a novel population of resident adult cardiac stem cells expressing PW1+ and their involvement in fibrotic remodeling after MI." @default.
• W2740137536 created "2017-08-08" @default.
• W2740137536 creator A5006820876 @default.
• W2740137536 creator A5009221246 @default.
• W2740137536 creator A5022209101 @default.
• W2740137536 creator A5022299218 @default.
• W2740137536 creator A5026971258 @default.
• W2740137536 creator A5033873633 @default.
• W2740137536 creator A5044835837 @default.
• W2740137536 creator A5046397844 @default.
• W2740137536 creator A5048546765 @default.
• W2740137536 creator A5062125057 @default.
• W2740137536 creator A5064676705 @default.
• W2740137536 creator A5070136141 @default.
• W2740137536 creator A5070456505 @default.
• W2740137536 creator A5070950600 @default.
• W2740137536 creator A5073037289 @default.
• W2740137536 creator A5077621721 @default.
• W2740137536 creator A5086214775 @default.
• W2740137536 date "2017-08-01" @default.
• W2740137536 modified "2023-10-17" @default.
• W2740137536 title "Fibrogenic Potential of PW1/Peg3 Expressing Cardiac Stem Cells" @default.
• W2740137536 cites W1965629756 @default.
• W2740137536 cites W1968628080 @default.
• W2740137536 cites W1974848384 @default.
• W2740137536 cites W1994553956 @default.
• W2740137536 cites W1999574084 @default.
• W2740137536 cites W2002402846 @default.
• W2740137536 cites W2010368308 @default.
• W2740137536 cites W2013702641 @default.
• W2740137536 cites W2015872862 @default.
• W2740137536 cites W2024804994 @default.
• W2740137536 cites W2028036560 @default.
• W2740137536 cites W2050561917 @default.
• W2740137536 cites W2054238236 @default.
• W2740137536 cites W2055323054 @default.
• W2740137536 cites W2070772918 @default.
• W2740137536 cites W2081005181 @default.
• W2740137536 cites W2091545998 @default.
• W2740137536 cites W2097875303 @default.
• W2740137536 cites W2109945048 @default.
• W2740137536 cites W2121737869 @default.
• W2740137536 cites W2122059700 @default.
• W2740137536 cites W2122883124 @default.
• W2740137536 cites W2123766297 @default.
• W2740137536 cites W2135060727 @default.
• W2740137536 cites W2154860326 @default.
• W2740137536 cites W2161918376 @default.
• W2740137536 cites W2163475306 @default.
• W2740137536 cites W2164963842 @default.
• W2740137536 cites W2165160576 @default.
• W2740137536 cites W2172058095 @default.
• W2740137536 cites W2234452149 @default.
• W2740137536 cites W2254879660 @default.
• W2740137536 cites W2549677106 @default.
• W2740137536 cites W4252232449 @default.
• W2740137536 doi "https://doi.org/10.1016/j.jacc.2017.06.010" @default.
• W2740137536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28774379" @default.
• W2740137536 hasPublicationYear "2017" @default.
• W2740137536 type Work @default.
• W2740137536 sameAs 2740137536 @default.
• W2740137536 citedByCount "27" @default.
• W2740137536 countsByYear W27401375362017 @default.
• W2740137536 countsByYear W27401375362018 @default.
• W2740137536 countsByYear W27401375362019 @default.
• W2740137536 countsByYear W27401375362020 @default.
• W2740137536 countsByYear W27401375362021 @default.
• W2740137536 countsByYear W27401375362022 @default.
• W2740137536 countsByYear W27401375362023 @default.
• W2740137536 crossrefType "journal-article" @default.
• W2740137536 hasAuthorship W2740137536A5006820876 @default.
• W2740137536 hasAuthorship W2740137536A5009221246 @default.
• W2740137536 hasAuthorship W2740137536A5022209101 @default.
• W2740137536 hasAuthorship W2740137536A5022299218 @default.
• W2740137536 hasAuthorship W2740137536A5026971258 @default.
• W2740137536 hasAuthorship W2740137536A5033873633 @default.
• W2740137536 hasAuthorship W2740137536A5044835837 @default.
• W2740137536 hasAuthorship W2740137536A5046397844 @default.
• W2740137536 hasAuthorship W2740137536A5048546765 @default.
• W2740137536 hasAuthorship W2740137536A5062125057 @default.
• W2740137536 hasAuthorship W2740137536A5064676705 @default.
• W2740137536 hasAuthorship W2740137536A5070136141 @default.
• W2740137536 hasAuthorship W2740137536A5070456505 @default.
• W2740137536 hasAuthorship W2740137536A5070950600 @default.
• W2740137536 hasAuthorship W2740137536A5073037289 @default.
• W2740137536 hasAuthorship W2740137536A5077621721 @default.
• W2740137536 hasAuthorship W2740137536A5086214775 @default.
• W2740137536 hasBestOaLocation W27401375361 @default.
• W2740137536 hasConcept C142724271 @default.
• W2740137536 hasConcept C198826908 @default.
• W2740137536 hasConcept C207865475 @default.
• W2740137536 hasConcept C2780559512 @default.
• W2740137536 hasConcept C28328180 @default.
• W2740137536 hasConcept C71924100 @default.
• W2740137536 hasConcept C86803240 @default.
• W2740137536 hasConcept C95444343 @default.
• W2740137536 hasConceptScore W2740137536C142724271 @default.
• W2740137536 hasConceptScore W2740137536C198826908 @default.

• next