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- W2740193786 abstract "Abstract Background Maraviroc isanHIV entry inhibitor thatalters theconformation ofCCR5andispoorlyeffi-cientinpatientsinfectedby viruses thatuseCXCR4 asan entrycoreceptor. Thegoal ofthisstudywastoassess the capacityofultra-deeppyrosequencing(UDPS)anddifferentdataanalysis approachestocharacterize HIVtropismatbaselineandpredict thetherapeuticoutcome onmaraviroc treatment. Methods 113patients withdetectableHIV-1 RNA onHAARTweretreatedwithmaraviroc. Theviro-logical response wasassessedatmonths1,3and6.ThesequenceoftheHIV V3 loopwasdeterminedatbaselineandpredictionofmaraviroc responsebydifferent software andinter-pretation algorithmswasanalyzed. Results UDPSfollowedbyanalysiswiththePyrotropsoftwareorgeno2phenoalgorithmprovidedbetterpredictionoftheresponsetomaravirocthanSangersequencing.WealsofoundthattheH34Y/SsubstitutionintheV3loopwasthestrongestindividualpredictorofmaravirocresponse,strongerthansubstitutionsatpositions11or25classicallyusedininterpretationalgorithms. Conclusions UDPS isapowerfultoolthatcanbeused withconfidencetopredict maraviroc response inHIV-1-infectedpatients. Improvement ofthepredictivevalueofinterpretation algorithms is" @default.
- W2740193786 created "2017-08-08" @default.
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- W2740193786 date "2015-01-01" @default.
- W2740193786 modified "2023-10-18" @default.
- W2740193786 title "HIV-1 Coreceptor Usage Assessment by Ultra-Deep Pyrosequencing and Response to" @default.
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