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- W2740244672 abstract "This chapter focuses on the main types of DNA alkylating drugs. These include nitrogen mustards, aziridines, epoxides, methanesulfonates, nitrosoureas, triazenes, methylhydrazines, 1,3,5-Triazines, platinum complexes, and miscellaneous alkylating and acylating antitumor agents. Since the active species involved in DNA alkylation by nitrogen mustards is an aziridinium cation, several aziridine derivatives were also tested as antitumor agents. The high reactivity of the epoxide ring toward nucleophilic groups in biomolecules is the basis of the use of ethylene oxide to sterilize substances that would be damaged by heat, including medical supplies such as bandages, sutures, and surgical implements. Methanesulfonate is a good leaving group because of the efficient delocalization of negative charge between three oxygen atoms. For this reason, several compounds containing two methanesulfonate groups separated by a polymethylene chain were tested as antitumor agents, finding that the optimal activity corresponded to the compound with four carbon atoms. Streptozotocin differs from other nitrosoureas in that it does not cross the blood–brain barrier because of its high hydrophilicity, and it also shows a relatively low myelosuppression because of decreased entry into bone marrow cells." @default.
- W2740244672 created "2017-08-08" @default.
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- W2740244672 date "2008-01-01" @default.
- W2740244672 modified "2023-10-16" @default.
- W2740244672 title "DNA Alkylating Agents" @default.
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- W2740244672 doi "https://doi.org/10.1016/b978-0-444-52824-7.00005-6" @default.
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