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• W2740255890 abstract "Summary Introduction. Retrospective studies showed that hemodiafiltra- tion was associated with a reduced risk of mortality compared with standard hemodialysis in the patients with end-stage renal disease. Recently, a few prospective randomized clinical trials found no advantage in survival with hemodiafiltration as com- pared with high-flux hemodialysis and low-flux hemodialysis. The aim of this study was to compare the parameters of hemo- dialysis adequacy and two-year survival of patients depending on the modality of hemodialysis. Material and Methods. A total of 159 hemodialysis patients were divided into 3 groups according to the type of hemodialysis treatment: group A - low- flux hemodialysis, group B - high-flux hemodialysis, and group C - hemodiafiltration. All patients had the same duration of hemodialysis sessions. The analysis included average one-year biochemical parameters, and two-year survival of patients. Re- sults. The patients on hemodiafiltration were significantly younger, they had longer dialysis vintage and higher index of dialysis adequancy as compared with the patients on low-flux hemodialysis and high-flux hemodialysis, but without a differ- ence between the two latter groups. Compared to the patients on low-flux hemodialysis, the patients on hemodiafiltration and high-flux hemodialysis had significantly higher hemoglobin value with less frequent erythropoietin stimulating agent use. According to Kaplan-Meier survival analysis, the patients on hemodiafiltration and high-flux hemodialysis had significantly better two-year survival than the patients on low-flux hemodi- alysis. Cox proportional hazards model confirmed that high-flux hemodialysis caused a significantly lower relative risk of mortal- ity (56% reduction) compared to low-flux hemodialysis (hazard ratio 0.44; P=0.026), and hemodiafiltration caused a 58% reduc- tion in the relative risk of mortality compared to low-flux dialy- sis (hazard ratio 0.42; P=0.105), but without a statistical sig- nificance. Conclusion. This study has demonstrated two-year survival benefit with high-flux hemodialysis and hemodiafiltra- tion compared with low-flux hemodialysis. There was no dif- ference in survival between high-flux hemodialysis and hemo-" @default.
• W2740255890 created "2017-08-08" @default.
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• W2740255890 date "2015-01-01" @default.
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• W2740255890 title "PARAMETERS OF HEMODIALYSIS ADEQUACY AND PATIENTS' SURVIVAL DEPENDING ON TREATMENT MODALITIES PARAMETRI ADEKVATNOSTI HEMODIJALIZE I PREŽIVLJAVANJE BOLESNIKA U ZAVISNOSTI OD MODALITETA LEČENJA" @default.
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