FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740259311> ?p ?o ?g. }

• W2740259311 abstract "ABSTRACT Iceland is free of the major infectious diseases of horses. However, in 2010 an epidemic of respiratory disease of unknown cause spread through the country’s native horse population of 77,000. Microbiological investigations ruled out known viral agents but identified the opportunistic pathogen Streptococcus equi subsp. zooepidemicus ( S. zooepidemicus ) in diseased animals. We sequenced the genomes of 257 isolates of S. zooepidemicus to differentiate epidemic from endemic strains. We found that although multiple endemic clones of S. zooepidemicus were present, one particular clone, sequence type 209 (ST209), was likely to have been responsible for the epidemic. Concurrent with the epidemic, ST209 was also recovered from a human case of septicemia, highlighting the pathogenic potential of this strain. Epidemiological investigation revealed that the incursion of this strain into one training yard during February 2010 provided a nidus for the infection of multiple horses that then transmitted the strain to farms throughout Iceland. This study represents the first time that whole-genome sequencing has been used to investigate an epidemic on a national scale to identify the likely causative agent and the link to an associated zoonotic infection. Our data highlight the importance of national biosecurity to protect vulnerable populations of animals and also demonstrate the potential impact of S. zooepidemicus transmission to other animals, including humans. IMPORTANCE An epidemic of respiratory disease affected almost the entire native Icelandic horse population of 77,000 animals in 2010, resulting in a self-imposed ban on the export of horses and significant economic costs to associated industries. Although the speed of transmission suggested that a viral pathogen was responsible, only the presence of the opportunistic pathogen Streptococcus zooepidemicus was consistent with the observed clinical signs. We applied genomic sequencing to differentiate epidemic from endemic strains and to shed light on the rapid transmission of the epidemic strain throughout Iceland. We further highlight the ability of epidemic and endemic strains of S. zooepidemicus to infect other animals, including humans. This study represents the first time that whole-genome sequencing has been used to elucidate an outbreak on a national scale and identify the likely causative agent." @default.
• W2740259311 created "2017-08-08" @default.
• W2740259311 creator A5006522116 @default.
• W2740259311 creator A5007167293 @default.
• W2740259311 creator A5008515156 @default.
• W2740259311 creator A5018365964 @default.
• W2740259311 creator A5018400239 @default.
• W2740259311 creator A5019402081 @default.
• W2740259311 creator A5033752704 @default.
• W2740259311 creator A5047037920 @default.
• W2740259311 creator A5049639550 @default.
• W2740259311 creator A5072528521 @default.
• W2740259311 creator A5077698000 @default.
• W2740259311 creator A5081427636 @default.
• W2740259311 creator A5084268602 @default.
• W2740259311 date "2017-09-06" @default.
• W2740259311 modified "2023-10-11" @default.
• W2740259311 title "Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases" @default.
• W2740259311 cites W1507028065 @default.
• W2740259311 cites W1967966999 @default.
• W2740259311 cites W1971117019 @default.
• W2740259311 cites W1972145956 @default.
• W2740259311 cites W1972805520 @default.
• W2740259311 cites W1975720659 @default.
• W2740259311 cites W1977677039 @default.
• W2740259311 cites W1979579917 @default.
• W2740259311 cites W1980030331 @default.
• W2740259311 cites W1984390786 @default.
• W2740259311 cites W1989044021 @default.
• W2740259311 cites W1989764192 @default.
• W2740259311 cites W1998405590 @default.
• W2740259311 cites W1999068352 @default.
• W2740259311 cites W2006046355 @default.
• W2740259311 cites W2009320470 @default.
• W2740259311 cites W2016586980 @default.
• W2740259311 cites W2019290089 @default.
• W2740259311 cites W2020774835 @default.
• W2740259311 cites W2035908932 @default.
• W2740259311 cites W2037409969 @default.
• W2740259311 cites W2043526525 @default.
• W2740259311 cites W2058459913 @default.
• W2740259311 cites W2059657252 @default.
• W2740259311 cites W2067043031 @default.
• W2740259311 cites W2088775267 @default.
• W2740259311 cites W2094407176 @default.
• W2740259311 cites W2102099558 @default.
• W2740259311 cites W2108234281 @default.
• W2740259311 cites W2110835349 @default.
• W2740259311 cites W2120960119 @default.
• W2740259311 cites W2121667771 @default.
• W2740259311 cites W2129124272 @default.
• W2740259311 cites W2130362098 @default.
• W2740259311 cites W2132606647 @default.
• W2740259311 cites W2134529369 @default.
• W2740259311 cites W2136969516 @default.
• W2740259311 cites W2139736670 @default.
• W2740259311 cites W2144438055 @default.
• W2740259311 cites W2150112973 @default.
• W2740259311 cites W2151307688 @default.
• W2740259311 cites W2155900717 @default.
• W2740259311 cites W2158630561 @default.
• W2740259311 cites W2164238430 @default.
• W2740259311 cites W2168696662 @default.
• W2740259311 cites W2288293206 @default.
• W2740259311 cites W2299346637 @default.
• W2740259311 cites W2402375053 @default.
• W2740259311 cites W2717674187 @default.
• W2740259311 cites W93588716 @default.
• W2740259311 doi "https://doi.org/10.1128/mbio.00826-17" @default.
• W2740259311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5539424" @default.
• W2740259311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28765219" @default.
• W2740259311 hasPublicationYear "2017" @default.
• W2740259311 type Work @default.
• W2740259311 sameAs 2740259311 @default.
• W2740259311 citedByCount "20" @default.
• W2740259311 countsByYear W27402593112017 @default.
• W2740259311 countsByYear W27402593112018 @default.
• W2740259311 countsByYear W27402593112019 @default.
• W2740259311 countsByYear W27402593112020 @default.
• W2740259311 countsByYear W27402593112021 @default.
• W2740259311 countsByYear W27402593112022 @default.
• W2740259311 countsByYear W27402593112023 @default.
• W2740259311 crossrefType "journal-article" @default.
• W2740259311 hasAuthorship W2740259311A5006522116 @default.
• W2740259311 hasAuthorship W2740259311A5007167293 @default.
• W2740259311 hasAuthorship W2740259311A5008515156 @default.
• W2740259311 hasAuthorship W2740259311A5018365964 @default.
• W2740259311 hasAuthorship W2740259311A5018400239 @default.
• W2740259311 hasAuthorship W2740259311A5019402081 @default.
• W2740259311 hasAuthorship W2740259311A5033752704 @default.
• W2740259311 hasAuthorship W2740259311A5047037920 @default.
• W2740259311 hasAuthorship W2740259311A5049639550 @default.
• W2740259311 hasAuthorship W2740259311A5072528521 @default.
• W2740259311 hasAuthorship W2740259311A5077698000 @default.
• W2740259311 hasAuthorship W2740259311A5081427636 @default.
• W2740259311 hasAuthorship W2740259311A5084268602 @default.
• W2740259311 hasBestOaLocation W27402593111 @default.
• W2740259311 hasConcept C142724271 @default.
• W2740259311 hasConcept C151730666 @default.
• W2740259311 hasConcept C159047783 @default.

• next