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- W2740260912 endingPage "235" @default.
- W2740260912 startingPage "235" @default.
- W2740260912 abstract "The phylum proteobacteria contains a wide array of Gram-negative marine bacteria. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. This has led to the discovery of a growing number of medically relevant natural products, including novel leads for the treatment of multidrug-resistant Staphylococcus aureus (MRSA) and cancer. Of equal interest, marine proteobacteria produce natural products whose structure and biosynthetic mechanisms differ from those of their terrestrial and actinobacterial counterparts. Notable features of secondary metabolites produced by marine proteobacteria include halogenation, sulfur-containing heterocycles, non-ribosomal peptides, and polyketides with unusual biosynthetic logic. As advances are made in the technology associated with functional genomics, such as computational sequence analysis, targeted DNA manipulation, and heterologous expression, it has become easier to probe the mechanisms for natural product biosynthesis. This review will focus on genomics driven approaches to understanding the biosynthetic mechanisms for natural products produced by marine proteobacteria." @default.
- W2740260912 created "2017-08-08" @default.
- W2740260912 creator A5041142993 @default.
- W2740260912 creator A5055620032 @default.
- W2740260912 creator A5073931289 @default.
- W2740260912 date "2017-08-01" @default.
- W2740260912 modified "2023-10-18" @default.
- W2740260912 title "Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies" @default.
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