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• W2740285874 abstract "// Cheng Xu 1, * , Xiaoqing Liu 2, 4, * , Yibo Geng 1 , Qingran Bai 2, 4 , Changcun Pan 1 , Yu Sun 1 , Xin Chen 1 , Hai Yu 1 , Yuliang Wu 1 , Peng Zhang 1 , Wenhao Wu 1 , Yu Wang 1 , Zhen Wu 1 , Junting Zhang 1 , Zhaohui Wang 3 , Rui Yang 3 , Jenna Lewis 3 , Darell Bigner 3 , Fangping Zhao 5 , Yiping He 3 , Hai Yan 3 , Qin Shen 2 and Liwei Zhang 1 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China 2 Center for Life Sciences, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing, China 3 Department of Pathology, Duke University Medical Center, The Preston Robert Tisch Brain Tumor Center, The Pediatric Brain Tumor Foundation Institute, Durham, North Carolina, USA 4 Peking-Tsinghua-NIBS Graduate Program, School of Life Sciences, Tsinghua University, Beijing, China 5 Genotron Health (Beijing) Co. Ltd, Beijing, China * These authors have contributed equally to this work Correspondence to: Liwei Zhang, email: zlwttn@gmail.com Qin Shen, email: shenqin@mail.tsinghua.edu.cn Keywords: DIPG, pre-clinical model, patient-derived cell line, orthotopic xenograft, pediatric brain tumor Received: March 07, 2017     Accepted: May 22, 2017     Published: July 28, 2017 ABSTRACT Diffuse intrinsic pontine glioma (DIPG) is a devastating brain tumor, with a median survival of less than one year. Due to enormous difficulties in the acquisition of DIPG specimens and the sophisticated technique required to perform brainstem orthotopic injection, only a handful of DIPG pre-clinical models are available. In this study, we successfully established eight patient-derived DIPG cell lines, mostly derived from treatment-naïve surgery or biopsy specimens. These patient-derived cell lines can be stably passaged in serum-free neural stem cell media and displayed distinct morphologies, growth rates and chromosome abnormalities. In addition, these cells retained genomic hallmarks identical to original human DIPG tumors. Notably, expression of several neural stem cell lineage markers was observed in DIPG cell lines. Moreover, three out of eight cell lines can form orthotopic tumors in mouse brainstem by stereotactic injection and these tumors faithfully represented the characteristics of human DIPG by magnetic resonance imaging (MRI) and histopathological staining. Taken together, we established DIPG pre-clinical models resembling human DIPG and they provided a valuable resource for future biological and therapeutic studies." @default.
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• W2740285874 date "2017-07-28" @default.
• W2740285874 modified "2023-10-17" @default.
• W2740285874 title "Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors" @default.
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• W2740285874 doi "https://doi.org/10.18632/oncotarget.19656" @default.
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