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• W2740297777 abstract "Abstract High-fat diet-induced hypothalamic metabolic inflammation is emerging as a cause for the development of obesity. It is acknowledged that Toll-like receptor4 (TLR4) signaling plays a crucial role in triggering of the hypothalamic metabolic inflammation during the course of diet-induced obesity. Whether hypothalamic arcuate nucleus (ARC)-restricted TLR4 knockdown improves obesity-related metabolic disorders remains unexplored. In this study, we used TLR4 shRNA lentiviral particles to suppress the TLR4 expression in the hypothalamic ARC of diet-induced obese rat model by stereotaxic injection. Our results demonstrate that ARC-restricted TLR4 knockdown protects obese rats from diet-induced weight gain and energy intake, from diet-induced impaired glucose homeostasis and peripheral insulin resistance, and from high-fat diet-induced hepatic steatosis and adipocyte hypertrophy. Thus, we define ARC-restricted TLR4 knockdown as a potential strategy to combat metabolic disorders associated with obesity." @default.
• W2740297777 created "2017-08-08" @default.
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• W2740297777 date "2017-08-07" @default.
• W2740297777 modified "2023-10-11" @default.
• W2740297777 title "Knockdown of Tlr4 in the Arcuate Nucleus Improves Obesity Related Metabolic Disorders" @default.
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• W2740297777 doi "https://doi.org/10.1038/s41598-017-07858-6" @default.
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