Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740338843> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2740338843 abstract "Patient-derived xenograft (PDX) mouse models of cancer were first established in 1969 and were very actively used in the 1970’s and 1980’s. After a long period of eclipse, PDX models began to re-emerge in the early part of the present century. PDX models have potential as an important component of personalized precision cancer therapy. However, most PDX models currently offered to patients have their tumors subcutaneously transplanted in immunodeficient mice, which rarely metastasize. In contrast, orthotopic-transplant patient-derived models, termed patient-derived orthotopic xenografts (PDOX), usually metastasize as in the patient. Orthotopic models are critically important for the patient, since both primary and metastatic tumors develop and they can have differential chemosensitivity, not detectable in subcutaneous tumor models. We review first studies of cancer cell lines which have different drug response patterns at the orthotopic and subcutaneous cites in mouse models. We then review a subcutaneous nude mouse model of patient HER-2 expressing cervical carcinoma that was not sensitive to entinostat (a benzamide histone deacetylase inhibitor). In the PDOX model, entinostat was not effective against the primary tumor. However, entinostat significantly reduced the metastatic tumor burden, compared to the primary tumor in the PDOX model. Thus, only the PDOX model could be used to discover the anti-metastatic activity of entinostat for this patient. We emphasize the importance of using mouse models that can accurately recapitulate metastatic cancer for precisely individualizing cancer therapy." @default.
- W2740338843 created "2017-08-08" @default.
- W2740338843 creator A5040819666 @default.
- W2740338843 date "2017-01-01" @default.
- W2740338843 modified "2023-09-27" @default.
- W2740338843 title "Why Patient-Derived Mouse Models Need to Be Orthotopic" @default.
- W2740338843 cites W1492549565 @default.
- W2740338843 cites W1569875761 @default.
- W2740338843 cites W1592125379 @default.
- W2740338843 cites W1805852575 @default.
- W2740338843 cites W1969705513 @default.
- W2740338843 cites W1995987937 @default.
- W2740338843 cites W1997855844 @default.
- W2740338843 cites W1998139955 @default.
- W2740338843 cites W2026504110 @default.
- W2740338843 cites W2028701135 @default.
- W2740338843 cites W2052625497 @default.
- W2740338843 cites W2075733574 @default.
- W2740338843 cites W2077484102 @default.
- W2740338843 cites W2102339709 @default.
- W2740338843 cites W2109598226 @default.
- W2740338843 cites W2271083698 @default.
- W2740338843 cites W2306887830 @default.
- W2740338843 cites W2342246138 @default.
- W2740338843 cites W2419037363 @default.
- W2740338843 cites W2467162260 @default.
- W2740338843 cites W249545773 @default.
- W2740338843 cites W2516251801 @default.
- W2740338843 cites W2526123185 @default.
- W2740338843 cites W2527335053 @default.
- W2740338843 cites W2550476383 @default.
- W2740338843 cites W2572657810 @default.
- W2740338843 cites W2601907443 @default.
- W2740338843 cites W2626307008 @default.
- W2740338843 cites W347202097 @default.
- W2740338843 doi "https://doi.org/10.1007/978-3-319-57424-0_20" @default.
- W2740338843 hasPublicationYear "2017" @default.
- W2740338843 type Work @default.
- W2740338843 sameAs 2740338843 @default.
- W2740338843 citedByCount "1" @default.
- W2740338843 countsByYear W27403388432021 @default.
- W2740338843 crossrefType "book-chapter" @default.
- W2740338843 hasAuthorship W2740338843A5040819666 @default.
- W2740338843 hasConcept C104317684 @default.
- W2740338843 hasConcept C121608353 @default.
- W2740338843 hasConcept C126322002 @default.
- W2740338843 hasConcept C143998085 @default.
- W2740338843 hasConcept C2778305200 @default.
- W2740338843 hasConcept C2779013556 @default.
- W2740338843 hasConcept C2780283643 @default.
- W2740338843 hasConcept C502942594 @default.
- W2740338843 hasConcept C55493867 @default.
- W2740338843 hasConcept C64927066 @default.
- W2740338843 hasConcept C71924100 @default.
- W2740338843 hasConcept C86803240 @default.
- W2740338843 hasConceptScore W2740338843C104317684 @default.
- W2740338843 hasConceptScore W2740338843C121608353 @default.
- W2740338843 hasConceptScore W2740338843C126322002 @default.
- W2740338843 hasConceptScore W2740338843C143998085 @default.
- W2740338843 hasConceptScore W2740338843C2778305200 @default.
- W2740338843 hasConceptScore W2740338843C2779013556 @default.
- W2740338843 hasConceptScore W2740338843C2780283643 @default.
- W2740338843 hasConceptScore W2740338843C502942594 @default.
- W2740338843 hasConceptScore W2740338843C55493867 @default.
- W2740338843 hasConceptScore W2740338843C64927066 @default.
- W2740338843 hasConceptScore W2740338843C71924100 @default.
- W2740338843 hasConceptScore W2740338843C86803240 @default.
- W2740338843 hasLocation W27403388431 @default.
- W2740338843 hasOpenAccess W2740338843 @default.
- W2740338843 hasPrimaryLocation W27403388431 @default.
- W2740338843 hasRelatedWork W1979372400 @default.
- W2740338843 hasRelatedWork W2024194401 @default.
- W2740338843 hasRelatedWork W2120191503 @default.
- W2740338843 hasRelatedWork W2134433047 @default.
- W2740338843 hasRelatedWork W2140152960 @default.
- W2740338843 hasRelatedWork W2318451339 @default.
- W2740338843 hasRelatedWork W2319222851 @default.
- W2740338843 hasRelatedWork W2363757177 @default.
- W2740338843 hasRelatedWork W2417747280 @default.
- W2740338843 hasRelatedWork W2740214440 @default.
- W2740338843 hasRelatedWork W2741220812 @default.
- W2740338843 hasRelatedWork W2752791607 @default.
- W2740338843 hasRelatedWork W2753018468 @default.
- W2740338843 hasRelatedWork W2791981903 @default.
- W2740338843 hasRelatedWork W2890261574 @default.
- W2740338843 hasRelatedWork W2960313704 @default.
- W2740338843 hasRelatedWork W3006589200 @default.
- W2740338843 hasRelatedWork W3031750830 @default.
- W2740338843 hasRelatedWork W3083755930 @default.
- W2740338843 hasRelatedWork W3120573521 @default.
- W2740338843 isParatext "false" @default.
- W2740338843 isRetracted "false" @default.
- W2740338843 magId "2740338843" @default.
- W2740338843 workType "book-chapter" @default.