FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740348879> ?p ?o ?g. }

• W2740348879 endingPage "5110" @default.
• W2740348879 startingPage "5102" @default.
• W2740348879 abstract "Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator that we have previously shown to be associated with an aggressive clinical phenotype in cystic fibrosis. It possesses unique tauto-merase enzymatic activity. However, to date, no human-derived substrate has been identified that has the capacity to interact with this cytokine’s unique tautomerase activity. This led us to hypothesize that MIF may have the capacity to interact with external substrates. We describe for the first time how Pseudomonas aeruginosa can utilize human recombinant MIF (rMIF) to significantly (P < 0.01) enhance its endogenous biofilm formation. Our in vivo studies demonstrate that utilizing a small-molecular-weight inhibitor targeting MIF’s tautomerase activity (SCD-19) significantly reduces the inflammatory response in a murine pulmonary chronic P. aeruginosa model. In addition, we show that in in vitro experiments, pretreatment of P. aeruginosa with rMIF is associated with reduced bacterial killing by tobramycin. Our novel findings support the concept of an anti-MIF strategy that targets this enzymatic activity as a potential future antibacterial therapeutic approach.—Tynan, A., Mawhinney, L., Armstrong, M. E., O’Reilly, C., Kennedy, S., Caraher, E., Jülicher, K., O’Dwyer, D., Maher, L., Schaffer, K., Fabre, A., McKone, E.F., Leng, L., Bucala, R., Bernhagen, J., Cooke, G., Donnelly, S. C. Macrophage migration inhibitory factor enhances Pseudomonas aeruginosa biofilm formation, potentially contributing to cystic fibrosis pathogenesis. FASEB J. 31, 5102–5110 (2017). www.fasebj.org" @default.
• W2740348879 created "2017-08-08" @default.
• W2740348879 creator A5007562353 @default.
• W2740348879 creator A5008065494 @default.
• W2740348879 creator A5008402391 @default.
• W2740348879 creator A5012285481 @default.
• W2740348879 creator A5020928977 @default.
• W2740348879 creator A5033053791 @default.
• W2740348879 creator A5042662639 @default.
• W2740348879 creator A5042683920 @default.
• W2740348879 creator A5047236388 @default.
• W2740348879 creator A5047503290 @default.
• W2740348879 creator A5052909330 @default.
• W2740348879 creator A5052948894 @default.
• W2740348879 creator A5057686096 @default.
• W2740348879 creator A5078541857 @default.
• W2740348879 creator A5080194585 @default.
• W2740348879 creator A5085861694 @default.
• W2740348879 creator A5086796840 @default.
• W2740348879 date "2017-08-02" @default.
• W2740348879 modified "2023-10-14" @default.
• W2740348879 title "Macrophage migration inhibitory factor enhances <i>Pseudomonas aeruginosa</i> biofilm formation, potentially contributing to cystic fibrosis pathogenesis" @default.
• W2740348879 cites W109149868 @default.
• W2740348879 cites W1574734561 @default.
• W2740348879 cites W1734802175 @default.
• W2740348879 cites W1971419546 @default.
• W2740348879 cites W1974433996 @default.
• W2740348879 cites W1991395851 @default.
• W2740348879 cites W1991922050 @default.
• W2740348879 cites W1992773104 @default.
• W2740348879 cites W1995910069 @default.
• W2740348879 cites W2010532522 @default.
• W2740348879 cites W2012064808 @default.
• W2740348879 cites W2014778624 @default.
• W2740348879 cites W2020847270 @default.
• W2740348879 cites W2021400094 @default.
• W2740348879 cites W2026569411 @default.
• W2740348879 cites W2029174607 @default.
• W2740348879 cites W2032439102 @default.
• W2740348879 cites W2041464595 @default.
• W2740348879 cites W2045767889 @default.
• W2740348879 cites W2050204173 @default.
• W2740348879 cites W2051214236 @default.
• W2740348879 cites W2063405659 @default.
• W2740348879 cites W2088505995 @default.
• W2740348879 cites W2090056328 @default.
• W2740348879 cites W2112279465 @default.
• W2740348879 cites W2126995562 @default.
• W2740348879 cites W2131581428 @default.
• W2740348879 cites W2131631258 @default.
• W2740348879 cites W2138779519 @default.
• W2740348879 cites W2149646558 @default.
• W2740348879 cites W2152058417 @default.
• W2740348879 cites W2157584041 @default.
• W2740348879 cites W2161313438 @default.
• W2740348879 cites W2163737726 @default.
• W2740348879 cites W221215209 @default.
• W2740348879 cites W2271314815 @default.
• W2740348879 doi "https://doi.org/10.1096/fj.201700463r" @default.
• W2740348879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6159708" @default.
• W2740348879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28768722" @default.
• W2740348879 hasPublicationYear "2017" @default.
• W2740348879 type Work @default.
• W2740348879 sameAs 2740348879 @default.
• W2740348879 citedByCount "9" @default.
• W2740348879 countsByYear W27403488792018 @default.
• W2740348879 countsByYear W27403488792019 @default.
• W2740348879 countsByYear W27403488792020 @default.
• W2740348879 countsByYear W27403488792021 @default.
• W2740348879 countsByYear W27403488792022 @default.
• W2740348879 countsByYear W27403488792023 @default.
• W2740348879 crossrefType "journal-article" @default.
• W2740348879 hasAuthorship W2740348879A5007562353 @default.
• W2740348879 hasAuthorship W2740348879A5008065494 @default.
• W2740348879 hasAuthorship W2740348879A5008402391 @default.
• W2740348879 hasAuthorship W2740348879A5012285481 @default.
• W2740348879 hasAuthorship W2740348879A5020928977 @default.
• W2740348879 hasAuthorship W2740348879A5033053791 @default.
• W2740348879 hasAuthorship W2740348879A5042662639 @default.
• W2740348879 hasAuthorship W2740348879A5042683920 @default.
• W2740348879 hasAuthorship W2740348879A5047236388 @default.
• W2740348879 hasAuthorship W2740348879A5047503290 @default.
• W2740348879 hasAuthorship W2740348879A5052909330 @default.
• W2740348879 hasAuthorship W2740348879A5052948894 @default.
• W2740348879 hasAuthorship W2740348879A5057686096 @default.
• W2740348879 hasAuthorship W2740348879A5078541857 @default.
• W2740348879 hasAuthorship W2740348879A5080194585 @default.
• W2740348879 hasAuthorship W2740348879A5085861694 @default.
• W2740348879 hasAuthorship W2740348879A5086796840 @default.
• W2740348879 hasBestOaLocation W27403488791 @default.
• W2740348879 hasConcept C104177226 @default.
• W2740348879 hasConcept C104317684 @default.
• W2740348879 hasConcept C126322002 @default.
• W2740348879 hasConcept C150903083 @default.
• W2740348879 hasConcept C164027704 @default.
• W2740348879 hasConcept C185592680 @default.
• W2740348879 hasConcept C202751555 @default.
• W2740348879 hasConcept C203014093 @default.

• next