FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740374012> ?p ?o ?g. }

• W2740374012 endingPage "482" @default.
• W2740374012 startingPage "464" @default.
• W2740374012 abstract "Transient Receptor Potential (TRP) proteins form cation channels characterized by a wide variety of activation triggers. Here, we overview a group of TRP channels that respond to reactive redox species to transduce physiological signals, with a focus on TRPA1 and its role in oxygen physiology. Our systematic evaluation of oxidation sensitivity using cysteine-selective reactive disulphides with different redox potentials reveals that TRPA1 has the highest sensitivity to oxidants/electrophiles among the TRP channels, which enables it to sense O2. Proline hydroxylation by O2-dependent hydroxylases also regulates the O2-sensing function by inhibiting TRPA1 in normoxia; TRPA1 is activated by hypoxia through relief from the inhibition and by hyperoxia through cysteine oxidation that overrides the inhibition. TRPA1 enhances neuronal discharges induced by hyperoxia and hypoxia in the vagus to underlie respiratory adaptation to changes in O2 availability. This importance of TRPA1 in non-carotid body O2 sensors can be extended to the universal significance of redox-sensitive TRP channels in O2 adaptation." @default.
• W2740374012 created "2017-08-08" @default.
• W2740374012 creator A5046015612 @default.
• W2740374012 creator A5049910888 @default.
• W2740374012 creator A5078967543 @default.
• W2740374012 creator A5087516603 @default.
• W2740374012 date "2017-01-01" @default.
• W2740374012 modified "2023-10-18" @default.
• W2740374012 title "TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O₂ sensing" @default.
• W2740374012 cites W1491124232 @default.
• W2740374012 cites W1511198581 @default.
• W2740374012 cites W1516271714 @default.
• W2740374012 cites W1559892880 @default.
• W2740374012 cites W1562645017 @default.
• W2740374012 cites W1576543894 @default.
• W2740374012 cites W1757500502 @default.
• W2740374012 cites W1888762249 @default.
• W2740374012 cites W1965273313 @default.
• W2740374012 cites W1972003023 @default.
• W2740374012 cites W1973524650 @default.
• W2740374012 cites W1973547785 @default.
• W2740374012 cites W1974058597 @default.
• W2740374012 cites W1975189886 @default.
• W2740374012 cites W1977539713 @default.
• W2740374012 cites W1979044083 @default.
• W2740374012 cites W1980798939 @default.
• W2740374012 cites W1981478519 @default.
• W2740374012 cites W1982112078 @default.
• W2740374012 cites W1983671012 @default.
• W2740374012 cites W1984533345 @default.
• W2740374012 cites W1986477333 @default.
• W2740374012 cites W1988673487 @default.
• W2740374012 cites W1988875133 @default.
• W2740374012 cites W1991346678 @default.
• W2740374012 cites W1992900177 @default.
• W2740374012 cites W1993582195 @default.
• W2740374012 cites W1994473516 @default.
• W2740374012 cites W1995091371 @default.
• W2740374012 cites W1995330222 @default.
• W2740374012 cites W1996024251 @default.
• W2740374012 cites W1997808089 @default.
• W2740374012 cites W1999529899 @default.
• W2740374012 cites W2000429979 @default.
• W2740374012 cites W2003764772 @default.
• W2740374012 cites W2006404566 @default.
• W2740374012 cites W2008241137 @default.
• W2740374012 cites W2009745570 @default.
• W2740374012 cites W2009967312 @default.
• W2740374012 cites W2010860671 @default.
• W2740374012 cites W2011350367 @default.
• W2740374012 cites W2012896102 @default.
• W2740374012 cites W2013180604 @default.
• W2740374012 cites W2016354937 @default.
• W2740374012 cites W2018660511 @default.
• W2740374012 cites W2019651398 @default.
• W2740374012 cites W2020833052 @default.
• W2740374012 cites W2021727710 @default.
• W2740374012 cites W2021786044 @default.
• W2740374012 cites W2022846088 @default.
• W2740374012 cites W2024093325 @default.
• W2740374012 cites W2025348662 @default.
• W2740374012 cites W2031848382 @default.
• W2740374012 cites W2032833833 @default.
• W2740374012 cites W2035167975 @default.
• W2740374012 cites W2035257142 @default.
• W2740374012 cites W2038471736 @default.
• W2740374012 cites W2039246411 @default.
• W2740374012 cites W2039497915 @default.
• W2740374012 cites W2040664792 @default.
• W2740374012 cites W2041641034 @default.
• W2740374012 cites W2047426956 @default.
• W2740374012 cites W2052870492 @default.
• W2740374012 cites W2054357177 @default.
• W2740374012 cites W2059596845 @default.
• W2740374012 cites W2061850743 @default.
• W2740374012 cites W2062978707 @default.
• W2740374012 cites W2063630842 @default.
• W2740374012 cites W2063952275 @default.
• W2740374012 cites W2064171438 @default.
• W2740374012 cites W2065533426 @default.
• W2740374012 cites W2066581734 @default.
• W2740374012 cites W2067071582 @default.
• W2740374012 cites W2068644383 @default.
• W2740374012 cites W2070768836 @default.
• W2740374012 cites W2071496657 @default.
• W2740374012 cites W2073293904 @default.
• W2740374012 cites W2073898725 @default.
• W2740374012 cites W2075100277 @default.
• W2740374012 cites W2076975188 @default.
• W2740374012 cites W2077744054 @default.
• W2740374012 cites W2080833269 @default.
• W2740374012 cites W2082661664 @default.
• W2740374012 cites W2085094809 @default.
• W2740374012 cites W2085157974 @default.
• W2740374012 cites W2086715542 @default.
• W2740374012 cites W2087077009 @default.
• W2740374012 cites W2087828263 @default.
• W2740374012 cites W2090720624 @default.

• next