Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740376592> ?p ?o ?g. }
- W2740376592 abstract "Abstract Infection of mice with strains of Plasmodium yoelii parasites can result in different pathology, but molecular mechanisms to explain this variation are unclear. Here we show that a P . yoelii gene encoding a HECT-like E3 ubiquitin ligase ( Pyheul ) influences parasitemia and host mortality. We genetically cross two lethal parasites with distinct disease phenotypes, and identify 43 genetically diverse progeny by typing with microsatellites and 9230 single-nucleotide polymorphisms. A genome-wide quantitative trait loci scan links parasite growth and host mortality to two major loci on chromosomes 1 and 7 with LOD (logarithm of the odds) scores = 6.1 and 8.1, respectively. Allelic exchange of partial sequences of Pyheul in the chromosome 7 locus and modification of the gene expression alter parasite growth and host mortality. This study identifies a gene that may have a function in parasite growth, virulence, and host–parasite interaction, and therefore could be a target for drug or vaccine development." @default.
- W2740376592 created "2017-08-08" @default.
- W2740376592 creator A5000434988 @default.
- W2740376592 creator A5006398697 @default.
- W2740376592 creator A5010595914 @default.
- W2740376592 creator A5016796082 @default.
- W2740376592 creator A5022793691 @default.
- W2740376592 creator A5028156362 @default.
- W2740376592 creator A5041118447 @default.
- W2740376592 creator A5048305965 @default.
- W2740376592 creator A5052883326 @default.
- W2740376592 creator A5061592542 @default.
- W2740376592 creator A5062029424 @default.
- W2740376592 creator A5062940889 @default.
- W2740376592 creator A5064148275 @default.
- W2740376592 creator A5073938095 @default.
- W2740376592 creator A5079682637 @default.
- W2740376592 creator A5089753752 @default.
- W2740376592 date "2017-08-09" @default.
- W2740376592 modified "2023-10-12" @default.
- W2740376592 title "A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence" @default.
- W2740376592 cites W1872721700 @default.
- W2740376592 cites W1886811890 @default.
- W2740376592 cites W1908153401 @default.
- W2740376592 cites W1951648042 @default.
- W2740376592 cites W1966634500 @default.
- W2740376592 cites W1967351936 @default.
- W2740376592 cites W1975520875 @default.
- W2740376592 cites W1980624449 @default.
- W2740376592 cites W1993545625 @default.
- W2740376592 cites W1994057928 @default.
- W2740376592 cites W1996378347 @default.
- W2740376592 cites W2002607497 @default.
- W2740376592 cites W2004250476 @default.
- W2740376592 cites W2007954622 @default.
- W2740376592 cites W2025629876 @default.
- W2740376592 cites W2027988262 @default.
- W2740376592 cites W2040597239 @default.
- W2740376592 cites W2040611232 @default.
- W2740376592 cites W2041618720 @default.
- W2740376592 cites W2042069836 @default.
- W2740376592 cites W2048700728 @default.
- W2740376592 cites W2048992607 @default.
- W2740376592 cites W2049655197 @default.
- W2740376592 cites W2053949131 @default.
- W2740376592 cites W2055991279 @default.
- W2740376592 cites W2059641385 @default.
- W2740376592 cites W2061183950 @default.
- W2740376592 cites W2064110684 @default.
- W2740376592 cites W2064938586 @default.
- W2740376592 cites W2069881609 @default.
- W2740376592 cites W2070335304 @default.
- W2740376592 cites W2076077595 @default.
- W2740376592 cites W2077871758 @default.
- W2740376592 cites W2079744876 @default.
- W2740376592 cites W2083547256 @default.
- W2740376592 cites W2090000225 @default.
- W2740376592 cites W2091453599 @default.
- W2740376592 cites W2093098860 @default.
- W2740376592 cites W2102155970 @default.
- W2740376592 cites W2107435367 @default.
- W2740376592 cites W2117521332 @default.
- W2740376592 cites W2124648107 @default.
- W2740376592 cites W2131810775 @default.
- W2740376592 cites W2133972984 @default.
- W2740376592 cites W2134648428 @default.
- W2740376592 cites W2136187101 @default.
- W2740376592 cites W2140101704 @default.
- W2740376592 cites W2146859644 @default.
- W2740376592 cites W2148795627 @default.
- W2740376592 cites W2149945426 @default.
- W2740376592 cites W2162952994 @default.
- W2740376592 cites W2163915500 @default.
- W2740376592 cites W2165583797 @default.
- W2740376592 cites W2167412008 @default.
- W2740376592 cites W2169431889 @default.
- W2740376592 cites W2404545519 @default.
- W2740376592 cites W2571954563 @default.
- W2740376592 doi "https://doi.org/10.1038/s41467-017-00267-3" @default.
- W2740376592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5548792" @default.
- W2740376592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28790316" @default.
- W2740376592 hasPublicationYear "2017" @default.
- W2740376592 type Work @default.
- W2740376592 sameAs 2740376592 @default.
- W2740376592 citedByCount "14" @default.
- W2740376592 countsByYear W27403765922018 @default.
- W2740376592 countsByYear W27403765922019 @default.
- W2740376592 countsByYear W27403765922020 @default.
- W2740376592 countsByYear W27403765922021 @default.
- W2740376592 countsByYear W27403765922022 @default.
- W2740376592 countsByYear W27403765922023 @default.
- W2740376592 crossrefType "journal-article" @default.
- W2740376592 hasAuthorship W2740376592A5000434988 @default.
- W2740376592 hasAuthorship W2740376592A5006398697 @default.
- W2740376592 hasAuthorship W2740376592A5010595914 @default.
- W2740376592 hasAuthorship W2740376592A5016796082 @default.
- W2740376592 hasAuthorship W2740376592A5022793691 @default.
- W2740376592 hasAuthorship W2740376592A5028156362 @default.
- W2740376592 hasAuthorship W2740376592A5041118447 @default.
- W2740376592 hasAuthorship W2740376592A5048305965 @default.