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- W2740398469 abstract "Antigenic ofinfectious organisms is a majorfactor inevasion ofthehostimmuneresponse. However, there hasbeennodefinitive demonstration ofthis phenomenon inthemalaria parasite Plasmodium falciparum. Inthis study, cloned parasites wereexamined serologically and biochemically fortheexpression oferythrocyte surface anti- gens. Acloned line ofP.fakciparum gaverise toprogeny that expressed antigenically distinct forms ofanerythrocyte surface antigen butwereotherwise identical. Thisdemonstrates that antigenic differences onthesurface ofP.fakiparum-infected erythrocytes canarise byantigenic ofclonal parasite populations. Theantigenic differences wereshowntoresult fromantigenic oftheparasite-encoded protein, theP. falciparum erythrocyte membrane protein 1. Infectious organisms canevade thehost immuneresponse by expressing different antigenic forms ofsurface molecules. An important stepininvestigating these antigenic differences is todetermine whether cloned organisms canchange the antigenic phenotype ofa specific surface molecule. This indicates thatantigenic differences areduetoantigenic variation rather thantotheantigenic diversity created by multiple different stable alleles within amixedpopulation of organisms. Forexample, intheprimate malaria, Plasmodium knowlesi, andtheAfrican trypanosome, Trypanosoma bru- cei, clonal parasite populations canundergo antigenic vari- ation insurface molecules (1-5). Incontrast, antigenic diver- sity intheSantigen, anon-surface antigen ofPlasmodium falciparum, reflects alarge number ofdifferent stable alleles (6), andtheSantigen phenotype ofcloned parasites isstable (R.Anders, personal communication). Erythrocytes infected withthetrophozoite andschizont stages ofP.falciparum haveparasite-determined antigens on their surface thatarepotential targets ofhostimmunere- sponses. Onesucherythrocyte surface antigen isalarge, radioiodinatable protein knownasP.falciparum erythrocyte membrane protein 1(PfEMP1) (7-9). PfEMP1islikely tobe thesamemolecule astheprotein sequestrin, recently described byOckenhouse andothers (10). PfEMP1appears tobethetarget antigen forantibodies thatagglutinate in- fected erythrocytes andinhibit cytoadherence between in- fected erythrocytes andvenular endothelium. These antibod- iesmayhaveanimportant role innaturally acquired immu- nity toP.falciparum malaria, although field studies suggest that there arealarge numberofdifferent antigenic forms of PfEMP1(11). Wereport herethat acloned parental line ofP.falciparum, maintained invitro, gaverise toclones that differed intheir agglutination byclone-specific antisera andhadantigenically distinct forms ofPfEMP1. Theclones werederived fromthe sameparental clone andwereidentical withrespect toall other genetic markers. Wetherefore conclude that antigenic change inP.falciparum canbegenerated bythemechanism ofantigenic variation." @default.
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- W2740398469 date "1991-01-01" @default.
- W2740398469 modified "2023-09-26" @default.
- W2740398469 title "Antigenic variation inPlasmodium falciparum (malaria/Plasmodiumfalkiparum erythrocyte membrane protein 1/cytoadherence)" @default.
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- W2740398469 hasPublicationYear "1991" @default.
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