FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740420011> ?p ?o ?g. }

• W2740420011 endingPage "e66" @default.
• W2740420011 startingPage "e66" @default.
• W2740420011 abstract "Objective: The reported variability in the BP response to renal denervation (RDN) has limited its clinical application. A selection of inappropriate patient cohorts (pathophysiology failure) and the inability to confirm that sufficient renal denervation has actually been achieved (technical failure) represent major obstacles. Here, we aimed to assess whether changes in the plasma concentration of chromogranin A (ChrA), a sympathetic nerve vesicular protein, could predict the blood pressure response to RDN. Design and method: Thirty one consecutive patients with resistant hypertension (65% males, age 61.7 ± 1.7 years, mean ± SEM) who underwent RDN (Symplicity® catheter) were included in this study. We analysed plasma concentrations of ChrA by ELISA. Samples from renal vein and renal artery were taken prior to (T0) and immediately after (T1) RDN. Associations between ChrA concentrations and venous and arterial noradrenaline (NA) concentrations, as well as NA spillover were analysed. Automated office systolic (SBP) and diastolic blood pressure (DBP) measurements were obtained before (T0) and 3 months (M3) after RDN using the Omron HEM-907 monitor. Results: Office BP decreased significantly at M3: SBP: 166.9 ± 3.95 vs 149.8 ± 5.43 mmHg (p = 0.0001), DBP: 89.9 ± 3.06 vs 84.5 ± 3.4 mmHg (p = 0.0045). Arterial ChrA at T0 was correlated with the change in SBP from baseline to M3 (T0-M3) (r = 0.45, p = 0.015). At T0, the arterio-venous ChrA gradient was correlated with SBP change (r = 0.43, p = 0.02). At T1, this gradient was correlated with SBP (r = 0.38, p = 0.04) and DBP change (r = 0.34, p = 0.066). The delta (T0-T1) arterial ChrA was inversely correlated with the DBP change at M3 (T0-M3) (r = −0.50, p = 0.006) but not with SBP. No correlation was found for NA and NA spillover with blood pressure change. These results suggest: 1) higher arterial ChrA concentrations at baseline predicted a more pronounced BP decrease in response to RDN, 2) an increase of ChrA after RDN, potentially explained by the release of the ChrA contained in sympathetic axons, predicted the DBP decrease. It means that an acute change of ChrA could help to confirm the success of the procedure.Conclusions: ChrA might represent a predictor of BP response to RDN at M3. Further studies are needed to confirm these results." @default.
• W2740420011 created "2017-08-08" @default.
• W2740420011 creator A5001236718 @default.
• W2740420011 creator A5014744580 @default.
• W2740420011 creator A5017880299 @default.
• W2740420011 creator A5025935579 @default.
• W2740420011 creator A5041016234 @default.
• W2740420011 creator A5041356090 @default.
• W2740420011 creator A5045767106 @default.
• W2740420011 creator A5047370873 @default.
• W2740420011 creator A5086606783 @default.
• W2740420011 date "2017-09-01" @default.
• W2740420011 modified "2023-09-27" @default.
• W2740420011 title "[OP.7A.11] CHROMOGRANIN A AS A PREDICTIVE MARKER OF SUCCESSFUL RENAL DENERVATION" @default.
• W2740420011 doi "https://doi.org/10.1097/01.hjh.0000523148.28340.8c" @default.
• W2740420011 hasPublicationYear "2017" @default.
• W2740420011 type Work @default.
• W2740420011 sameAs 2740420011 @default.
• W2740420011 citedByCount "1" @default.
• W2740420011 countsByYear W27404200112017 @default.
• W2740420011 crossrefType "journal-article" @default.
• W2740420011 hasAuthorship W2740420011A5001236718 @default.
• W2740420011 hasAuthorship W2740420011A5014744580 @default.
• W2740420011 hasAuthorship W2740420011A5017880299 @default.
• W2740420011 hasAuthorship W2740420011A5025935579 @default.
• W2740420011 hasAuthorship W2740420011A5041016234 @default.
• W2740420011 hasAuthorship W2740420011A5041356090 @default.
• W2740420011 hasAuthorship W2740420011A5045767106 @default.
• W2740420011 hasAuthorship W2740420011A5047370873 @default.
• W2740420011 hasAuthorship W2740420011A5086606783 @default.
• W2740420011 hasConcept C10162356 @default.
• W2740420011 hasConcept C126322002 @default.
• W2740420011 hasConcept C126894567 @default.
• W2740420011 hasConcept C134018914 @default.
• W2740420011 hasConcept C164705383 @default.
• W2740420011 hasConcept C204232928 @default.
• W2740420011 hasConcept C2776634560 @default.
• W2740420011 hasConcept C2776805190 @default.
• W2740420011 hasConcept C2780091579 @default.
• W2740420011 hasConcept C2780177628 @default.
• W2740420011 hasConcept C3019558611 @default.
• W2740420011 hasConcept C71924100 @default.
• W2740420011 hasConcept C77231918 @default.
• W2740420011 hasConcept C84393581 @default.
• W2740420011 hasConceptScore W2740420011C10162356 @default.
• W2740420011 hasConceptScore W2740420011C126322002 @default.
• W2740420011 hasConceptScore W2740420011C126894567 @default.
• W2740420011 hasConceptScore W2740420011C134018914 @default.
• W2740420011 hasConceptScore W2740420011C164705383 @default.
• W2740420011 hasConceptScore W2740420011C204232928 @default.
• W2740420011 hasConceptScore W2740420011C2776634560 @default.
• W2740420011 hasConceptScore W2740420011C2776805190 @default.
• W2740420011 hasConceptScore W2740420011C2780091579 @default.
• W2740420011 hasConceptScore W2740420011C2780177628 @default.
• W2740420011 hasConceptScore W2740420011C3019558611 @default.
• W2740420011 hasConceptScore W2740420011C71924100 @default.
• W2740420011 hasConceptScore W2740420011C77231918 @default.
• W2740420011 hasConceptScore W2740420011C84393581 @default.
• W2740420011 hasIssue "Supplement 2" @default.
• W2740420011 hasLocation W27404200111 @default.
• W2740420011 hasOpenAccess W2740420011 @default.
• W2740420011 hasPrimaryLocation W27404200111 @default.
• W2740420011 hasRelatedWork W2171476985 @default.
• W2740420011 hasRelatedWork W2207553984 @default.
• W2740420011 hasRelatedWork W2365383810 @default.
• W2740420011 hasRelatedWork W2515983477 @default.
• W2740420011 hasRelatedWork W2605219122 @default.
• W2740420011 hasRelatedWork W2806669099 @default.
• W2740420011 hasRelatedWork W3046958404 @default.
• W2740420011 hasRelatedWork W3206798051 @default.
• W2740420011 hasRelatedWork W4281773870 @default.
• W2740420011 hasRelatedWork W2183586767 @default.
• W2740420011 hasVolume "35" @default.
• W2740420011 isParatext "false" @default.
• W2740420011 isRetracted "false" @default.
• W2740420011 magId "2740420011" @default.
• W2740420011 workType "article" @default.