Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740449860> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2740449860 endingPage "S213" @default.
- W2740449860 startingPage "S213" @default.
- W2740449860 abstract "Aim: Clinical guidelines recommend invasive management for patients presenting with acute coronary syndrome. However, patients included in randomised trials supporting this practice generally have minimal non-coronary risks. We evaluated the interaction between competing non-coronary risks and benefit of invasive management. Methods: All consecutive patients admitted to the Cardiac Care Unit of a tertiary hospital in South Australia in the later six-months of 2003-2011 with troponin elevation (>30ng/L) were included. “Cardiac-specific risk” was estimated using the GRACE score and “non-coronary risk” was estimated using the Charlson-Comorbidity-Index (CCI). Inverse-probability-of-treatment weightings were used to adjust for baseline differences between patients who did and did not receive invasive management. A multivariable flexible parametric model was used to characterise the time-varying hazard associated with invasive management. Results: Overall, 3057 patients were included with a median follow-up of 3274 days (IQR: 2562-4105). Based on CCI, 1786/3057 patients were classified as ‘low-risk’ (CCI ≤1; predicted 12-month mortality 4%), 461/3057 as ‘medium-risk’ (CCI 2-3; predicted 12-month mortality 11%), and 461/3057 as ‘high-risk’ (CCI ≥4; predicted 12-month mortality 27%); with 332(19%), 257(32%), 238(52%) patients receiving invasive management in the ‘low-,’ ‘medium-’ and ‘high-risk’ groups respectively. After adjustment, invasive management was associated with a significant reduction in overall-mortality in the ‘low-’ and ‘medium-risk’ groups (HR = 0.45, 95%CI:0.34-0.5; HR = 0.56, 95%CI:0.43-0.75); but not in the ‘high-risk’ group (HR = 1.26, 95%CI:0.87-1.81). The benefit of invasive management occurred early with an increase in very-early mortality seen in patients with non-coronary risks. Conclusions: Non-coronary risks should be considered when risk-stratifying and selecting patients for invasive management." @default.
- W2740449860 created "2017-08-08" @default.
- W2740449860 creator A5000451024 @default.
- W2740449860 creator A5006094590 @default.
- W2740449860 creator A5026970981 @default.
- W2740449860 creator A5027863578 @default.
- W2740449860 creator A5048932343 @default.
- W2740449860 creator A5049980522 @default.
- W2740449860 creator A5063083156 @default.
- W2740449860 creator A5086872963 @default.
- W2740449860 creator A5087850153 @default.
- W2740449860 date "2017-01-01" @default.
- W2740449860 modified "2023-09-27" @default.
- W2740449860 title "Invasive Management of Acute Coronary Syndrome: Interaction with Competing Risks" @default.
- W2740449860 doi "https://doi.org/10.1016/j.hlc.2017.06.388" @default.
- W2740449860 hasPublicationYear "2017" @default.
- W2740449860 type Work @default.
- W2740449860 sameAs 2740449860 @default.
- W2740449860 citedByCount "0" @default.
- W2740449860 crossrefType "journal-article" @default.
- W2740449860 hasAuthorship W2740449860A5000451024 @default.
- W2740449860 hasAuthorship W2740449860A5006094590 @default.
- W2740449860 hasAuthorship W2740449860A5026970981 @default.
- W2740449860 hasAuthorship W2740449860A5027863578 @default.
- W2740449860 hasAuthorship W2740449860A5048932343 @default.
- W2740449860 hasAuthorship W2740449860A5049980522 @default.
- W2740449860 hasAuthorship W2740449860A5063083156 @default.
- W2740449860 hasAuthorship W2740449860A5086872963 @default.
- W2740449860 hasAuthorship W2740449860A5087850153 @default.
- W2740449860 hasBestOaLocation W27404498601 @default.
- W2740449860 hasConcept C126322002 @default.
- W2740449860 hasConcept C141071460 @default.
- W2740449860 hasConcept C164705383 @default.
- W2740449860 hasConcept C194828623 @default.
- W2740449860 hasConcept C207103383 @default.
- W2740449860 hasConcept C2777698277 @default.
- W2740449860 hasConcept C2780904754 @default.
- W2740449860 hasConcept C36036425 @default.
- W2740449860 hasConcept C44249647 @default.
- W2740449860 hasConcept C500558357 @default.
- W2740449860 hasConcept C50382708 @default.
- W2740449860 hasConcept C71924100 @default.
- W2740449860 hasConceptScore W2740449860C126322002 @default.
- W2740449860 hasConceptScore W2740449860C141071460 @default.
- W2740449860 hasConceptScore W2740449860C164705383 @default.
- W2740449860 hasConceptScore W2740449860C194828623 @default.
- W2740449860 hasConceptScore W2740449860C207103383 @default.
- W2740449860 hasConceptScore W2740449860C2777698277 @default.
- W2740449860 hasConceptScore W2740449860C2780904754 @default.
- W2740449860 hasConceptScore W2740449860C36036425 @default.
- W2740449860 hasConceptScore W2740449860C44249647 @default.
- W2740449860 hasConceptScore W2740449860C500558357 @default.
- W2740449860 hasConceptScore W2740449860C50382708 @default.
- W2740449860 hasConceptScore W2740449860C71924100 @default.
- W2740449860 hasLocation W27404498601 @default.
- W2740449860 hasOpenAccess W2740449860 @default.
- W2740449860 hasPrimaryLocation W27404498601 @default.
- W2740449860 hasRelatedWork W2081278027 @default.
- W2740449860 hasRelatedWork W2134208843 @default.
- W2740449860 hasRelatedWork W2137017130 @default.
- W2740449860 hasRelatedWork W2213857236 @default.
- W2740449860 hasRelatedWork W2331315363 @default.
- W2740449860 hasRelatedWork W2518963241 @default.
- W2740449860 hasRelatedWork W2572837865 @default.
- W2740449860 hasRelatedWork W2889312762 @default.
- W2740449860 hasRelatedWork W3049631826 @default.
- W2740449860 hasRelatedWork W4284899107 @default.
- W2740449860 hasVolume "26" @default.
- W2740449860 isParatext "false" @default.
- W2740449860 isRetracted "false" @default.
- W2740449860 magId "2740449860" @default.
- W2740449860 workType "article" @default.