Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740456469> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2740456469 endingPage "e212" @default.
- W2740456469 startingPage "e211" @default.
- W2740456469 abstract "Objective: Although the failure of the SYMPLICITY-3 trial in reaching its primary efficacy end-point, the catheter-based renal sympathetic denervation (RDN) remains the only tool to improve blood pressure (BP) control in patient with true resistant hypertension (RH). In the Veneto region, RDN is authorized only in two specialized centers, but in selected cases, is also performed in hospitals organized in the so-called Hub-model. Patients with RH are at a high risk for developing serious cardiovascular events increasing the global health costs. In this study, we assess cost-effectiveness and short-term clinical benefits of RDN.Design and method: A 48-years old male, with a history of hypertension dated for over 10 years was annually admitted to our department for high BP levels not controlled by therapy until 7 anti-hypertensive drugs. The search for a cause of secondary hypertension revealed no clues. He was diabetic, overweight, with stage-3 of chronic renal disease and had multiple organ damage. At the last admission, BP averaged 226/128 mmHg and his medications were: amlodipine 20 mg, Ramipril 10 mg, spironolactone 25 mg, furosemide 50 mg, doxasozine 8 mg daily. 24h-ambulatory BP measurement (Figure 1A) confirmed RH. Patient underwent to RDN procedure using a third generation SpyralTM catheter, a device that is associated with a reduced procedural time, contrast use and radiation exposure. RDN was performed without complications, and after 48 h BP lowered up to 50 mmHg with 3 antihypertensive drugs (Figure 1B). Medical records of the 10 years before the last hospitalization were collected, and on medical DRG the global costs for RH management has been calculated and compared with the cost of the RDN procedure. Results: RDN therapy resulted in an increase on health benefit both for BP control and pharmacological treatment, so that patient stopped taking 4 anti-hypertensive drugs. In 10 years of admissions, the global health costs of hypertension management reached more than 57.000 Euro compared to the about 6,000 Euro of the RDN procedure. Conclusions: RDN offers a meaningful and cost-effective alternative for achieving BP control, where traditional combination of antihypertensive pharmacologic strategies, have been proven to be ineffective." @default.
- W2740456469 created "2017-08-08" @default.
- W2740456469 creator A5005012839 @default.
- W2740456469 creator A5007949435 @default.
- W2740456469 creator A5018790889 @default.
- W2740456469 creator A5023095328 @default.
- W2740456469 creator A5026008599 @default.
- W2740456469 creator A5035650470 @default.
- W2740456469 creator A5042984641 @default.
- W2740456469 creator A5051782233 @default.
- W2740456469 creator A5059946459 @default.
- W2740456469 creator A5076256143 @default.
- W2740456469 date "2017-09-01" @default.
- W2740456469 modified "2023-10-14" @default.
- W2740456469 title "[PP.15.20] COST-EFFECTIVENESS OF RENAL DENERVATION COMPARED TO ANTIHYPERTENSIVE DRUG THERAPY IN TRUE RESISTANT HYPERTENSION" @default.
- W2740456469 doi "https://doi.org/10.1097/01.hjh.0000523599.45669.69" @default.
- W2740456469 hasPublicationYear "2017" @default.
- W2740456469 type Work @default.
- W2740456469 sameAs 2740456469 @default.
- W2740456469 citedByCount "0" @default.
- W2740456469 crossrefType "journal-article" @default.
- W2740456469 hasAuthorship W2740456469A5005012839 @default.
- W2740456469 hasAuthorship W2740456469A5007949435 @default.
- W2740456469 hasAuthorship W2740456469A5018790889 @default.
- W2740456469 hasAuthorship W2740456469A5023095328 @default.
- W2740456469 hasAuthorship W2740456469A5026008599 @default.
- W2740456469 hasAuthorship W2740456469A5035650470 @default.
- W2740456469 hasAuthorship W2740456469A5042984641 @default.
- W2740456469 hasAuthorship W2740456469A5051782233 @default.
- W2740456469 hasAuthorship W2740456469A5059946459 @default.
- W2740456469 hasAuthorship W2740456469A5076256143 @default.
- W2740456469 hasConcept C126322002 @default.
- W2740456469 hasConcept C134018914 @default.
- W2740456469 hasConcept C141071460 @default.
- W2740456469 hasConcept C149323552 @default.
- W2740456469 hasConcept C2776379505 @default.
- W2740456469 hasConcept C2776805190 @default.
- W2740456469 hasConcept C2778198053 @default.
- W2740456469 hasConcept C2779646130 @default.
- W2740456469 hasConcept C2779888176 @default.
- W2740456469 hasConcept C2780192228 @default.
- W2740456469 hasConcept C2781267111 @default.
- W2740456469 hasConcept C35785553 @default.
- W2740456469 hasConcept C555293320 @default.
- W2740456469 hasConcept C71924100 @default.
- W2740456469 hasConcept C84393581 @default.
- W2740456469 hasConceptScore W2740456469C126322002 @default.
- W2740456469 hasConceptScore W2740456469C134018914 @default.
- W2740456469 hasConceptScore W2740456469C141071460 @default.
- W2740456469 hasConceptScore W2740456469C149323552 @default.
- W2740456469 hasConceptScore W2740456469C2776379505 @default.
- W2740456469 hasConceptScore W2740456469C2776805190 @default.
- W2740456469 hasConceptScore W2740456469C2778198053 @default.
- W2740456469 hasConceptScore W2740456469C2779646130 @default.
- W2740456469 hasConceptScore W2740456469C2779888176 @default.
- W2740456469 hasConceptScore W2740456469C2780192228 @default.
- W2740456469 hasConceptScore W2740456469C2781267111 @default.
- W2740456469 hasConceptScore W2740456469C35785553 @default.
- W2740456469 hasConceptScore W2740456469C555293320 @default.
- W2740456469 hasConceptScore W2740456469C71924100 @default.
- W2740456469 hasConceptScore W2740456469C84393581 @default.
- W2740456469 hasIssue "Supplement 2" @default.
- W2740456469 hasLocation W27404564691 @default.
- W2740456469 hasOpenAccess W2740456469 @default.
- W2740456469 hasPrimaryLocation W27404564691 @default.
- W2740456469 hasRelatedWork W121743643 @default.
- W2740456469 hasRelatedWork W2041007258 @default.
- W2740456469 hasRelatedWork W2099184338 @default.
- W2740456469 hasRelatedWork W2120805831 @default.
- W2740456469 hasRelatedWork W2384738201 @default.
- W2740456469 hasRelatedWork W2426285380 @default.
- W2740456469 hasRelatedWork W2442675013 @default.
- W2740456469 hasRelatedWork W2510212662 @default.
- W2740456469 hasRelatedWork W3115754666 @default.
- W2740456469 hasRelatedWork W4281789156 @default.
- W2740456469 hasVolume "35" @default.
- W2740456469 isParatext "false" @default.
- W2740456469 isRetracted "false" @default.
- W2740456469 magId "2740456469" @default.
- W2740456469 workType "article" @default.