Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740482014> ?p ?o ?g. }
- W2740482014 endingPage "1855" @default.
- W2740482014 startingPage "1846" @default.
- W2740482014 abstract "Abstract MDA5 is a RIG-I–like cytoplasmic sensor of dsRNA and certain RNA viruses, such as encephalomyocarditis virus, for the initiation of the IFN signaling cascade in the innate antiviral response. The affinity of MDA5 toward dsRNA is low, and its activity becomes optimal in the presence of unknown cellular coactivators. In this article, we report an essential coactivator function of dsRNA-binding protein PACT in mediating the MDA5-dependent type I IFN response. Virus-induced and polyinosinic-polycytidylic acid–induced activation of MDA5 were severely impaired in PACT-knockout cells and attenuated in PACT-knockdown cells, but they were potentiated when PACT was overexpressed. PACT augmented IRF3-dependent type I IFN production subsequent to dsRNA-induced activation of MDA5. In contrast, PACT had no influence on MDA5-mediated activation of NF-κB. PACT required dsRNA interaction for its action on MDA5 and promoted dsRNA-induced oligomerization of MDA5. PACT had little stimulatory effect on MDA5 mutants deficient for oligomerization and filament assembly. PACT colocalized with MDA5 in the cytoplasm and potentiated MDA5 recruitment to the dsRNA ligand. Taken together, these findings suggest that PACT functions as an essential cellular coactivator of RIG-I, as well as MDA5, and it facilitates RNA-induced formation of MDA5 oligomers." @default.
- W2740482014 created "2017-08-08" @default.
- W2740482014 creator A5008353502 @default.
- W2740482014 creator A5013473972 @default.
- W2740482014 creator A5024217010 @default.
- W2740482014 creator A5028951688 @default.
- W2740482014 creator A5058253076 @default.
- W2740482014 creator A5063203922 @default.
- W2740482014 creator A5080853242 @default.
- W2740482014 date "2017-09-01" @default.
- W2740482014 modified "2023-09-30" @default.
- W2740482014 title "PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization" @default.
- W2740482014 cites W1560860164 @default.
- W2740482014 cites W1886265516 @default.
- W2740482014 cites W1965031127 @default.
- W2740482014 cites W1965439215 @default.
- W2740482014 cites W1972425824 @default.
- W2740482014 cites W1972784345 @default.
- W2740482014 cites W1977709885 @default.
- W2740482014 cites W1978340521 @default.
- W2740482014 cites W1978525119 @default.
- W2740482014 cites W1988808478 @default.
- W2740482014 cites W1989032379 @default.
- W2740482014 cites W1991436313 @default.
- W2740482014 cites W1998735620 @default.
- W2740482014 cites W2003408748 @default.
- W2740482014 cites W2024054563 @default.
- W2740482014 cites W2025321617 @default.
- W2740482014 cites W2028575270 @default.
- W2740482014 cites W2035299766 @default.
- W2740482014 cites W2061482476 @default.
- W2740482014 cites W2070308943 @default.
- W2740482014 cites W2075666178 @default.
- W2740482014 cites W2086138941 @default.
- W2740482014 cites W2099009731 @default.
- W2740482014 cites W2100665873 @default.
- W2740482014 cites W2107458751 @default.
- W2740482014 cites W2111718823 @default.
- W2740482014 cites W2114235762 @default.
- W2740482014 cites W2115046796 @default.
- W2740482014 cites W2116520485 @default.
- W2740482014 cites W2119492463 @default.
- W2740482014 cites W2125566625 @default.
- W2740482014 cites W2130758536 @default.
- W2740482014 cites W2132403605 @default.
- W2740482014 cites W2137130773 @default.
- W2740482014 cites W2156891661 @default.
- W2740482014 cites W2165549831 @default.
- W2740482014 cites W2171500588 @default.
- W2740482014 cites W2171772533 @default.
- W2740482014 cites W2172337369 @default.
- W2740482014 cites W2289154867 @default.
- W2740482014 cites W2324048849 @default.
- W2740482014 cites W2337596057 @default.
- W2740482014 cites W2398957525 @default.
- W2740482014 cites W2564061339 @default.
- W2740482014 cites W2594236328 @default.
- W2740482014 cites W2596232252 @default.
- W2740482014 cites W2598530826 @default.
- W2740482014 cites W2625723100 @default.
- W2740482014 doi "https://doi.org/10.4049/jimmunol.1601493" @default.
- W2740482014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28760879" @default.
- W2740482014 hasPublicationYear "2017" @default.
- W2740482014 type Work @default.
- W2740482014 sameAs 2740482014 @default.
- W2740482014 citedByCount "35" @default.
- W2740482014 countsByYear W27404820142017 @default.
- W2740482014 countsByYear W27404820142018 @default.
- W2740482014 countsByYear W27404820142019 @default.
- W2740482014 countsByYear W27404820142020 @default.
- W2740482014 countsByYear W27404820142021 @default.
- W2740482014 countsByYear W27404820142022 @default.
- W2740482014 countsByYear W27404820142023 @default.
- W2740482014 crossrefType "journal-article" @default.
- W2740482014 hasAuthorship W2740482014A5008353502 @default.
- W2740482014 hasAuthorship W2740482014A5013473972 @default.
- W2740482014 hasAuthorship W2740482014A5024217010 @default.
- W2740482014 hasAuthorship W2740482014A5028951688 @default.
- W2740482014 hasAuthorship W2740482014A5058253076 @default.
- W2740482014 hasAuthorship W2740482014A5063203922 @default.
- W2740482014 hasAuthorship W2740482014A5080853242 @default.
- W2740482014 hasBestOaLocation W27404820141 @default.
- W2740482014 hasConcept C104317684 @default.
- W2740482014 hasConcept C134474686 @default.
- W2740482014 hasConcept C159047783 @default.
- W2740482014 hasConcept C166703698 @default.
- W2740482014 hasConcept C166957645 @default.
- W2740482014 hasConcept C185592680 @default.
- W2740482014 hasConcept C2191507 @default.
- W2740482014 hasConcept C2776178377 @default.
- W2740482014 hasConcept C2779073994 @default.
- W2740482014 hasConcept C55493867 @default.
- W2740482014 hasConcept C67705224 @default.
- W2740482014 hasConcept C77445288 @default.
- W2740482014 hasConcept C86339819 @default.
- W2740482014 hasConcept C86803240 @default.
- W2740482014 hasConcept C95444343 @default.
- W2740482014 hasConcept C95457728 @default.