Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740528040> ?p ?o ?g. }
- W2740528040 endingPage "956" @default.
- W2740528040 startingPage "945" @default.
- W2740528040 abstract "Targeting the TNFα pathway is a validated approach to the treatment of psoriasis. In this pathway, TACE stands out as a druggable target and has been the focus of in-house research programs. In this article, we present the discovery of clinical candidate 26a. Starting from hits plagued with poor solubility or genotoxicity, 26a was identified through thorough multiparameter optimisation. Showing robust in vivo activity in an oxazolone-mediated inflammation model, the compound was selected for development. Following a polymorph screen, the hydrochloride salt was selected and the synthesis was efficiently developed to yield the API in 47% overall yield." @default.
- W2740528040 created "2017-08-08" @default.
- W2740528040 creator A5000013407 @default.
- W2740528040 creator A5003693355 @default.
- W2740528040 creator A5006364010 @default.
- W2740528040 creator A5007025918 @default.
- W2740528040 creator A5009272820 @default.
- W2740528040 creator A5010613519 @default.
- W2740528040 creator A5013599256 @default.
- W2740528040 creator A5014030600 @default.
- W2740528040 creator A5016910509 @default.
- W2740528040 creator A5017356893 @default.
- W2740528040 creator A5023908036 @default.
- W2740528040 creator A5026476553 @default.
- W2740528040 creator A5027147959 @default.
- W2740528040 creator A5027322365 @default.
- W2740528040 creator A5029641904 @default.
- W2740528040 creator A5030656779 @default.
- W2740528040 creator A5037408832 @default.
- W2740528040 creator A5039096265 @default.
- W2740528040 creator A5040769083 @default.
- W2740528040 creator A5041581377 @default.
- W2740528040 creator A5042844846 @default.
- W2740528040 creator A5050212987 @default.
- W2740528040 creator A5052060835 @default.
- W2740528040 creator A5057733415 @default.
- W2740528040 creator A5057855270 @default.
- W2740528040 creator A5058552525 @default.
- W2740528040 creator A5062282123 @default.
- W2740528040 creator A5064968506 @default.
- W2740528040 creator A5068418111 @default.
- W2740528040 creator A5068503653 @default.
- W2740528040 creator A5068943280 @default.
- W2740528040 creator A5070726149 @default.
- W2740528040 creator A5073294663 @default.
- W2740528040 creator A5080799704 @default.
- W2740528040 creator A5085676662 @default.
- W2740528040 date "2018-02-01" @default.
- W2740528040 modified "2023-09-26" @default.
- W2740528040 title "Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis" @default.
- W2740528040 cites W1973426704 @default.
- W2740528040 cites W1978328441 @default.
- W2740528040 cites W1980968187 @default.
- W2740528040 cites W1981235319 @default.
- W2740528040 cites W2020412015 @default.
- W2740528040 cites W2033511432 @default.
- W2740528040 cites W2038295317 @default.
- W2740528040 cites W2039077237 @default.
- W2740528040 cites W2046893302 @default.
- W2740528040 cites W2050172669 @default.
- W2740528040 cites W2059566630 @default.
- W2740528040 cites W2061077566 @default.
- W2740528040 cites W2063138494 @default.
- W2740528040 cites W2071885136 @default.
- W2740528040 cites W2076483114 @default.
- W2740528040 cites W2079474526 @default.
- W2740528040 cites W2082291447 @default.
- W2740528040 cites W2086811860 @default.
- W2740528040 cites W2089541092 @default.
- W2740528040 cites W2110263699 @default.
- W2740528040 cites W2112138262 @default.
- W2740528040 cites W2155130143 @default.
- W2740528040 cites W2170139938 @default.
- W2740528040 cites W2335422960 @default.
- W2740528040 cites W2508971400 @default.
- W2740528040 cites W2591002277 @default.
- W2740528040 cites W76063910 @default.
- W2740528040 doi "https://doi.org/10.1016/j.bmc.2017.07.054" @default.
- W2740528040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28818461" @default.
- W2740528040 hasPublicationYear "2018" @default.
- W2740528040 type Work @default.
- W2740528040 sameAs 2740528040 @default.
- W2740528040 citedByCount "17" @default.
- W2740528040 countsByYear W27405280402016 @default.
- W2740528040 countsByYear W27405280402017 @default.
- W2740528040 countsByYear W27405280402018 @default.
- W2740528040 countsByYear W27405280402019 @default.
- W2740528040 countsByYear W27405280402020 @default.
- W2740528040 countsByYear W27405280402021 @default.
- W2740528040 countsByYear W27405280402022 @default.
- W2740528040 countsByYear W27405280402023 @default.
- W2740528040 crossrefType "journal-article" @default.
- W2740528040 hasAuthorship W2740528040A5000013407 @default.
- W2740528040 hasAuthorship W2740528040A5003693355 @default.
- W2740528040 hasAuthorship W2740528040A5006364010 @default.
- W2740528040 hasAuthorship W2740528040A5007025918 @default.
- W2740528040 hasAuthorship W2740528040A5009272820 @default.
- W2740528040 hasAuthorship W2740528040A5010613519 @default.
- W2740528040 hasAuthorship W2740528040A5013599256 @default.
- W2740528040 hasAuthorship W2740528040A5014030600 @default.
- W2740528040 hasAuthorship W2740528040A5016910509 @default.
- W2740528040 hasAuthorship W2740528040A5017356893 @default.
- W2740528040 hasAuthorship W2740528040A5023908036 @default.
- W2740528040 hasAuthorship W2740528040A5026476553 @default.
- W2740528040 hasAuthorship W2740528040A5027147959 @default.
- W2740528040 hasAuthorship W2740528040A5027322365 @default.
- W2740528040 hasAuthorship W2740528040A5029641904 @default.
- W2740528040 hasAuthorship W2740528040A5030656779 @default.