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- W2740565237 abstract "Abstract The Lyme disease agent, Borrelia burgdorferi , colonizes the gut of the tick Ixodes scapularis , which transmits the pathogen to vertebrate hosts including humans. Here we show that B . burgdorferi colonization increases the expression of several tick gut genes including pixr , encoding a secreted gut protein with a Reeler domain. RNA interference-mediated silencing of pixr , or immunity against PIXR in mice, impairs the ability of B . burgdorferi to colonize the tick gut. PIXR inhibits bacterial biofilm formation in vitro and in vivo. Abrogation of PIXR function in vivo results in alterations in the gut microbiome, metabolome and immune responses. These alterations influence the spirochete entering the tick gut in multiple ways. PIXR abrogation also impairs larval molting, indicative of its role in tick biology. This study highlights the role of the tick gut in actively managing its microbiome, and how this impacts B . burgdorferi colonization of its arthropod vector." @default.
- W2740565237 created "2017-08-08" @default.
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- W2740565237 date "2017-08-04" @default.
- W2740565237 modified "2023-10-18" @default.
- W2740565237 title "Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization" @default.
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- W2740565237 doi "https://doi.org/10.1038/s41467-017-00208-0" @default.
- W2740565237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5543126" @default.
- W2740565237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28775250" @default.
- W2740565237 hasPublicationYear "2017" @default.
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