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- W2740589045 abstract "In developed countries, 20-30% of the population suffer from type I allergies. One of the main allergens in the temperate climate zone is birch pollen. To date, the only causal treatment available is allergen-specific immunotherapy via the subcutaneous or the sublingual route. Successful allergen immunotherapy leads to the immunomodulation of an ongoing allergic TH2 response towards TH1, which can be monitored by a characteristic shift in the antibody and cytokine profile from a mainly humoral to a rather cellular immune reaction, resulting in a reduction of allergic symptoms. However, subcutaneous application can provoke severe adverse reactions; sublingual therapy is considered safe, but less effective in the long term [Roth-Walter, 2007]. Regarding patient compliance, oral immunotherapy would be preferable." @default.
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- W2740589045 date "2007-01-01" @default.
- W2740589045 modified "2023-09-27" @default.
- W2740589045 title "PLGA microparticles for oral allergen immunotherapy" @default.
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