Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740611357> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2740611357 abstract "The calcineurin inhibitors, tacrolimus and cyclosporine, are commonly used immunosuppressants, and transplant patients on these medications often develop gastrointestinal symptoms. This in vitro study investigated their effects on intestinal cellular respiration (the process of delivering nutrients and O 2 to the mitochondria, oxida- tion of reduced metabolic fuels, passage of electrons to O 2 , and synthesis of ATP) in C57BL/6 mice. For this purpose, a phosphorescence analyzer was used to measure cellular mitochondrial O 2 consumption (k c , µM O 2 min -1 mg -1 ) in fragments from the small intestine in the presence of 10 µM drug or 1.6 µL dimethyl-sulfoxide (drug vehicle). Tacrolimus and cyclosporine significantly reduced the rate of intestinal cellular respiration by 28% and 35%, re - spectively. Cyclosporine had no effects on cellular respiration in renal tissue. Intestinal respiration was unaffected by the multikinase inhibitors sorafenib and regorafenib, the mTOR inhibitors sirolimus and everolimus, the PI3K/ mTOR inhibitors BEZ235, GDC0980 and GSK2126458, the MEK inhibitor GSK1120212, and the P110δ inhibitor idelalisib. Thus, calcineurin inhibitors specifically impair intestinal cellular respiration. The mechanism and clinical significance of this in vitro event require further studies." @default.
- W2740611357 created "2017-08-08" @default.
- W2740611357 creator A5037980313 @default.
- W2740611357 creator A5064896722 @default.
- W2740611357 creator A5077142632 @default.
- W2740611357 date "2015-01-01" @default.
- W2740611357 modified "2023-09-24" @default.
- W2740611357 title "Original Article Calcineurin inhibitors suppress intestinal cellular respiration" @default.
- W2740611357 cites W1589421810 @default.
- W2740611357 cites W1592567691 @default.
- W2740611357 cites W1873439693 @default.
- W2740611357 cites W1968092563 @default.
- W2740611357 cites W2001582473 @default.
- W2740611357 cites W2027216818 @default.
- W2740611357 cites W2102799140 @default.
- W2740611357 cites W2140283022 @default.
- W2740611357 cites W2333514164 @default.
- W2740611357 cites W2396080878 @default.
- W2740611357 cites W2406314408 @default.
- W2740611357 cites W2418227259 @default.
- W2740611357 cites W988217994 @default.
- W2740611357 hasPublicationYear "2015" @default.
- W2740611357 type Work @default.
- W2740611357 sameAs 2740611357 @default.
- W2740611357 citedByCount "0" @default.
- W2740611357 crossrefType "journal-article" @default.
- W2740611357 hasAuthorship W2740611357A5037980313 @default.
- W2740611357 hasAuthorship W2740611357A5064896722 @default.
- W2740611357 hasAuthorship W2740611357A5077142632 @default.
- W2740611357 hasConcept C126322002 @default.
- W2740611357 hasConcept C128057223 @default.
- W2740611357 hasConcept C182215343 @default.
- W2740611357 hasConcept C185592680 @default.
- W2740611357 hasConcept C190283241 @default.
- W2740611357 hasConcept C2777921159 @default.
- W2740611357 hasConcept C28859421 @default.
- W2740611357 hasConcept C2909675724 @default.
- W2740611357 hasConcept C2911091166 @default.
- W2740611357 hasConcept C55493867 @default.
- W2740611357 hasConcept C59822182 @default.
- W2740611357 hasConcept C66517615 @default.
- W2740611357 hasConcept C71924100 @default.
- W2740611357 hasConcept C86554907 @default.
- W2740611357 hasConcept C86803240 @default.
- W2740611357 hasConcept C98274493 @default.
- W2740611357 hasConceptScore W2740611357C126322002 @default.
- W2740611357 hasConceptScore W2740611357C128057223 @default.
- W2740611357 hasConceptScore W2740611357C182215343 @default.
- W2740611357 hasConceptScore W2740611357C185592680 @default.
- W2740611357 hasConceptScore W2740611357C190283241 @default.
- W2740611357 hasConceptScore W2740611357C2777921159 @default.
- W2740611357 hasConceptScore W2740611357C28859421 @default.
- W2740611357 hasConceptScore W2740611357C2909675724 @default.
- W2740611357 hasConceptScore W2740611357C2911091166 @default.
- W2740611357 hasConceptScore W2740611357C55493867 @default.
- W2740611357 hasConceptScore W2740611357C59822182 @default.
- W2740611357 hasConceptScore W2740611357C66517615 @default.
- W2740611357 hasConceptScore W2740611357C71924100 @default.
- W2740611357 hasConceptScore W2740611357C86554907 @default.
- W2740611357 hasConceptScore W2740611357C86803240 @default.
- W2740611357 hasConceptScore W2740611357C98274493 @default.
- W2740611357 hasLocation W27406113571 @default.
- W2740611357 hasOpenAccess W2740611357 @default.
- W2740611357 hasPrimaryLocation W27406113571 @default.
- W2740611357 hasRelatedWork W1753227481 @default.
- W2740611357 hasRelatedWork W1966785288 @default.
- W2740611357 hasRelatedWork W1978821825 @default.
- W2740611357 hasRelatedWork W2092661658 @default.
- W2740611357 hasRelatedWork W2112842133 @default.
- W2740611357 hasRelatedWork W2151291770 @default.
- W2740611357 hasRelatedWork W2261669934 @default.
- W2740611357 hasRelatedWork W2528999970 @default.
- W2740611357 hasRelatedWork W2536800637 @default.
- W2740611357 hasRelatedWork W2539283095 @default.
- W2740611357 hasRelatedWork W2552352815 @default.
- W2740611357 hasRelatedWork W2573268330 @default.
- W2740611357 hasRelatedWork W2591901249 @default.
- W2740611357 hasRelatedWork W2619768326 @default.
- W2740611357 hasRelatedWork W2745136137 @default.
- W2740611357 hasRelatedWork W2770755676 @default.
- W2740611357 hasRelatedWork W2809992610 @default.
- W2740611357 hasRelatedWork W2980257051 @default.
- W2740611357 hasRelatedWork W3044480822 @default.
- W2740611357 hasRelatedWork W3207440653 @default.
- W2740611357 isParatext "false" @default.
- W2740611357 isRetracted "false" @default.
- W2740611357 magId "2740611357" @default.
- W2740611357 workType "article" @default.