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- W2740637836 abstract "Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt)1; heritability estimated from twin studies ranges from 30 to 50%2, and SNP-based heritability ranges from 6 to 15%3–6. Increased neuroticism is associated with poorer mental and physical health7,8, translating to high economic burden9. Genome-wide association studies (GWAS) of neuroticism have identified up to 11 associated genetic loci3,4. Here we report 116 significant independent loci from a GWAS of neuroticism in 329,821 UK Biobank participants; 15 of these loci replicated at P < 0.00045 in an unrelated cohort (N = 122,867). Genetic signals were enriched in neuronal genesis and differentiation pathways, and substantial genetic correlations were found between neuroticism and depressive symptoms (rg = 0.82, standard error (s.e.) = 0.03), major depressive disorder (MDD; rg = 0.69, s.e. = 0.07) and subjective well-being (rg = –0.68, s.e. = 0.03) alongside other mental health traits. These discoveries significantly advance understanding of neuroticism and its association with MDD. Analysis of 329,000 individuals in the UK Biobank identifies 116 loci associated with neuroticism. Genes implicated are enriched in neuronal differentiation pathways, and genetic correlations between neuroticism and other mental health traits are elucidated." @default.
- W2740637836 created "2017-08-08" @default.
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- W2740637836 date "2017-12-18" @default.
- W2740637836 modified "2023-10-05" @default.
- W2740637836 title "Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism" @default.
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- W2740637836 doi "https://doi.org/10.1038/s41588-017-0013-8" @default.
- W2740637836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5985926" @default.
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