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- W2740679715 abstract "Background: Most solid tumors have extensive stroma that not only facilitates the tumor progression but also impedes the delivery of the chemotherapeutic agents. Due to lack of any in-vitro system, presently it is difficult to evaluate any stroma-targeted therapies. Therefore, we developed an organoid system using labeled pancreatic cancer and stellate cell lines. Methods: Murine (FC 1295 and imPSCc-2) cell lines cultured in different combinations were grown as an organoid system using matrigel. The organoids, starting day four were treated with either gemcitabine or EC359, a novel mifepristone derived steroidal cytotoxic agent that targets tumor stroma, or both in combination. qRT-PCR analysis of activated stroma signature genes was performed on the mRNA isolated from different treatment groups. HE 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5792. doi:10.1158/1538-7445.AM2017-5792" @default.
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- W2740679715 date "2017-07-01" @default.
- W2740679715 modified "2023-09-25" @default.
- W2740679715 title "Abstract 5792: Development of cell line derived organoids to evaluate stroma targeted therapies in pancreatic cancer" @default.
- W2740679715 doi "https://doi.org/10.1158/1538-7445.am2017-5792" @default.
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