Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740702941> ?p ?o ?g. }
- W2740702941 endingPage "404" @default.
- W2740702941 startingPage "393" @default.
- W2740702941 abstract "Sepsis, among other pathologies, is an endotoxin tolerance (ET)-related disease. On admission, we classified 48 patients with sepsis into 3 subgroups according to the ex vivo response to lipopolysaccharide. This response correlates with the Acute Physiology and Chronic Health Evaluation (APACHE) II score and the ET degree. Moreover, the ET-related classification determines the outcome of these patients. Programmed cell death-ligand 1 (PD-L1) expression on septic monocytes is also linked with ET status. In addition to the regulation of cytokine production, one of the hallmarks of ET that significantly affects patients with sepsis is T-cell proliferation impairment or a poor switch to the adaptive response. PD-L1/programmed cell death-1 (PD-1) blocking and knockdown assays on tolerant monocytes from both patients with sepsis and the in vitro model reverted the impaired adaptive response. Mechanistically, the transcription factor hypoxia-inducible factor-1α (HIF1α) has been translocated into the nucleus and drives PD-L1 expression during ET in human monocytes. This fact, together with patient classification according to the ex vivo lipopolysaccharide response, opens an interesting field of study and potential personalized clinical applications, not only for sepsis but also for all ET-associated pathologies." @default.
- W2740702941 created "2017-08-08" @default.
- W2740702941 creator A5005604318 @default.
- W2740702941 creator A5012754015 @default.
- W2740702941 creator A5016296581 @default.
- W2740702941 creator A5019153950 @default.
- W2740702941 creator A5038576534 @default.
- W2740702941 creator A5040483533 @default.
- W2740702941 creator A5047015984 @default.
- W2740702941 creator A5047250028 @default.
- W2740702941 creator A5051818344 @default.
- W2740702941 creator A5052043026 @default.
- W2740702941 creator A5068727717 @default.
- W2740702941 creator A5077318494 @default.
- W2740702941 creator A5078491071 @default.
- W2740702941 creator A5080805037 @default.
- W2740702941 date "2017-07-29" @default.
- W2740702941 modified "2023-10-18" @default.
- W2740702941 title "PD-L1 Overexpression During Endotoxin Tolerance Impairs the Adaptive Immune Response in Septic Patients via HIF1α" @default.
- W2740702941 cites W1913780655 @default.
- W2740702941 cites W1925993589 @default.
- W2740702941 cites W1926790978 @default.
- W2740702941 cites W1944549670 @default.
- W2740702941 cites W1954571970 @default.
- W2740702941 cites W1983691837 @default.
- W2740702941 cites W1993197717 @default.
- W2740702941 cites W1997423398 @default.
- W2740702941 cites W1998427452 @default.
- W2740702941 cites W2012522637 @default.
- W2740702941 cites W2024196808 @default.
- W2740702941 cites W2036806228 @default.
- W2740702941 cites W2042956469 @default.
- W2740702941 cites W2053189438 @default.
- W2740702941 cites W2056411965 @default.
- W2740702941 cites W2057979643 @default.
- W2740702941 cites W2060122053 @default.
- W2740702941 cites W2062356301 @default.
- W2740702941 cites W2063214912 @default.
- W2740702941 cites W2066671159 @default.
- W2740702941 cites W2083513831 @default.
- W2740702941 cites W2087203965 @default.
- W2740702941 cites W2091761329 @default.
- W2740702941 cites W2101653483 @default.
- W2740702941 cites W2115476870 @default.
- W2740702941 cites W2120262777 @default.
- W2740702941 cites W2120599813 @default.
- W2740702941 cites W2129261650 @default.
- W2740702941 cites W2134421457 @default.
- W2740702941 cites W2136030067 @default.
- W2740702941 cites W2144601357 @default.
- W2740702941 cites W2145699122 @default.
- W2740702941 cites W2149360266 @default.
- W2740702941 cites W2154591406 @default.
- W2740702941 cites W2160578994 @default.
- W2740702941 cites W2160834915 @default.
- W2740702941 cites W2161771297 @default.
- W2740702941 cites W2166190627 @default.
- W2740702941 cites W2220466394 @default.
- W2740702941 cites W2257916459 @default.
- W2740702941 cites W2282181907 @default.
- W2740702941 cites W2291094902 @default.
- W2740702941 cites W2325491525 @default.
- W2740702941 cites W2346979395 @default.
- W2740702941 cites W2531471715 @default.
- W2740702941 cites W2556762229 @default.
- W2740702941 cites W2593799432 @default.
- W2740702941 cites W2768146862 @default.
- W2740702941 cites W4244545582 @default.
- W2740702941 doi "https://doi.org/10.1093/infdis/jix279" @default.
- W2740702941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28973671" @default.
- W2740702941 hasPublicationYear "2017" @default.
- W2740702941 type Work @default.
- W2740702941 sameAs 2740702941 @default.
- W2740702941 citedByCount "37" @default.
- W2740702941 countsByYear W27407029412018 @default.
- W2740702941 countsByYear W27407029412019 @default.
- W2740702941 countsByYear W27407029412020 @default.
- W2740702941 countsByYear W27407029412021 @default.
- W2740702941 countsByYear W27407029412022 @default.
- W2740702941 countsByYear W27407029412023 @default.
- W2740702941 crossrefType "journal-article" @default.
- W2740702941 hasAuthorship W2740702941A5005604318 @default.
- W2740702941 hasAuthorship W2740702941A5012754015 @default.
- W2740702941 hasAuthorship W2740702941A5016296581 @default.
- W2740702941 hasAuthorship W2740702941A5019153950 @default.
- W2740702941 hasAuthorship W2740702941A5038576534 @default.
- W2740702941 hasAuthorship W2740702941A5040483533 @default.
- W2740702941 hasAuthorship W2740702941A5047015984 @default.
- W2740702941 hasAuthorship W2740702941A5047250028 @default.
- W2740702941 hasAuthorship W2740702941A5051818344 @default.
- W2740702941 hasAuthorship W2740702941A5052043026 @default.
- W2740702941 hasAuthorship W2740702941A5068727717 @default.
- W2740702941 hasAuthorship W2740702941A5077318494 @default.
- W2740702941 hasAuthorship W2740702941A5078491071 @default.
- W2740702941 hasAuthorship W2740702941A5080805037 @default.
- W2740702941 hasBestOaLocation W27407029411 @default.
- W2740702941 hasConcept C150903083 @default.
- W2740702941 hasConcept C193419808 @default.