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- W2740732875 abstract "Recently subcutaneous implants are considered as a useful drug delivery system since they provide greater assurance of patient compliance and better therapeutic outcome than conventional drug therapies, especially in chronic disorders. Literature survey revealed that numerous studies have been conducted on subcutaneous implants to investigate use of different polymers for controlling the drug release for prolonged therapy, the pharmacokinetics and pharmacodyanamics of subcutaneous implants, the safety of the polymers. The science and engineering approaches in the development of implantable therapeutic systems have been well described in the literature. In this investigation, it was planned to prepare biodegradable subcutaneous implants of Naproxen, the NSAID by using gelatin as polymer and glycerin as a plasticizer, under aseptic conditions. The subcutaneous implants, weighing 10 mg were hardened by exposing them to hardening agents such as Glutaraldehyde. The formulated implants were evaluated for thickness, wt variation, drug content uniformity, free Glutaraldehyde, drug polymer interaction and sterility. In vitro drug release studies were conducted in phosphate buffer pH 7.4. The stability studies were carried out at ambient temperature for 3 months." @default.
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- W2740732875 date "2014-01-01" @default.
- W2740732875 modified "2023-09-24" @default.
- W2740732875 title "Research Article Characterization and In-vitro Evaluation of Drug Implants" @default.
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