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• W2740741519 abstract "No AccessJournal of UrologyAdult Urology1 Feb 20185′-tRNA Halves are Dysregulated in Clear Cell Renal Cell Carcinoma Chenming Zhao, Yuri Tolkach, Doris Schmidt, Glen Kristiansen, Stefan C. Müller, and Jörg Ellinger Chenming ZhaoChenming Zhao More articles by this author , Yuri TolkachYuri Tolkach More articles by this author , Doris SchmidtDoris Schmidt More articles by this author , Glen KristiansenGlen Kristiansen More articles by this author , Stefan C. MüllerStefan C. Müller More articles by this author , and Jörg EllingerJörg Ellinger More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.07.082AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In various malignancies RNA fragments are dysregulated. Our study was designed to determine the expression of 4, 5′-tRNA halves in the tissue and serum of patients with clear cell renal cell carcinoma. Materials and Methods: Tissue and serum samples of patients with clear cell renal cell carcinoma and nonmalignant disease were collected prospectively in our biobank. We isolated total RNA from 95 clear cell renal cell carcinomas and 50 normal renal tissues as well as serum RNA from 27 patients with clear cell renal cell carcinoma and 13 with nonmalignant urological disease. To specifically determine the expression of 5′-tRNA halves we dephosphorylated and ligated an adaptor nucleotide to the 3′ end of the tRNA halves. The expression levels of 4, 5′-tRNA halves (5′-tRNA-Arg-CCT, 5′-tRNA-Glu-CTC, 5′-tRNA-Leu-CAG and 5′-tRNA-Lys-TTT) were then measured by TaqMan® based quantitative reverse transcription-polymerase chain reaction. Results: All studied 5′-tRNA halves were down-regulated in clear cell renal cell carcinoma tissues, indicating a potential role as a tumor suppressor. Furthermore, we noted decreased expression of 5′-tRNA halves in patients with adverse clinicopathological parameters. All 5′-tRNA halves were expressed at lower levels in nonorgan confined clear cell renal cell carcinoma. The 5′-tRNA-Lys-TTT halves inversely correlated with ISUP (International Society of Urological Pathology) grade. In patients with clear cell renal cell carcinoma 5′-tRNA-Arg-CCT, 5′-tRNA-Glu-CTC and 5′-tRNA-Lys-TTT halves circulated at lower levels than in control subjects, indicating relevance as noninvasive biomarkers. Conclusions: In patients with clear cell renal cell carcinoma 5′-tRNA halves have potential as diagnostic and prognostic biomarkers. The 5′-tRNA halves may act in a tumor suppressive manner, which requires further research to confirm. References 1 : Epidemiology of renal cell carcinoma. 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Google Scholar 15 : Circulating microRNAs (miRNA) in serum of patients with prostate cancer. Urology2011; 77: 1265.e9. Google Scholar 16 : tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers. Nucleic Acids Res2016; 44: W185. Google Scholar 17 : Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly. J Biol Chem2010; 285: 10959. Google Scholar 18 : Angiogenin-induced tRNA fragments inhibit translation initiation. Mol Cell2011; 43: 613. Google Scholar © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAtala A (2018) Re: MYC Activation Cooperates with Vhl and Ink4a/Arf Loss to Induce Clear Cell Renal Cell CarcinomaJournal of Urology, VOL. 199, NO. 1, (31-31), Online publication date: 1-Jan-2018. Volume 199Issue 2February 2018Page: 378-383Supplementary Materials Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.Keywordsprognosistumorrenal celldiagnosisRNAbiomarkerscarcinomatransferMetricsAuthor Information Chenming Zhao More articles by this author Yuri Tolkach More articles by this author Doris Schmidt More articles by this author Glen Kristiansen More articles by this author Stefan C. Müller More articles by this author Jörg Ellinger More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2740741519 title "5′-tRNA Halves are Dysregulated in Clear Cell Renal Cell Carcinoma" @default.
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