Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740750197> ?p ?o ?g. }
- W2740750197 endingPage "044109" @default.
- W2740750197 startingPage "044109" @default.
- W2740750197 abstract "To develop biomimetic three-dimensional (3D) tissue constructs for drug screening and biological studies, engineered blood vessels should be integrated into the constructs to mimic the drug administration process in vivo. The development of perfusable vascularized 3D tissue constructs for studying the drug administration process through an engineered endothelial layer remains an area of intensive research. Here, we report the development of a simple 3D vascularized liver tissue model to study drug toxicity through the incorporation of an engineered endothelial layer. Using a sacrificial bioprinting technique, a hollow microchannel was successfully fabricated in the 3D liver tissue construct created with HepG2/C3A cells encapsulated in a gelatin methacryloyl hydrogel. After seeding human umbilical vein endothelial cells (HUVECs) into the microchannel, we obtained a vascularized tissue construct containing a uniformly coated HUVEC layer within the hollow microchannel. The inclusion of the HUVEC layer into the scaffold resulted in delayed permeability of biomolecules into the 3D liver construct. In addition, the vascularized construct containing the HUVEC layer showed an increased viability of the HepG2/C3A cells within the 3D scaffold compared to that of the 3D liver constructs without the HUVEC layer, demonstrating a protective role of the introduced endothelial cell layer. The 3D vascularized liver model presented in this study is anticipated to provide a better and more accurate in vitro liver model system for future drug toxicity testing." @default.
- W2740750197 created "2017-08-08" @default.
- W2740750197 creator A5000860056 @default.
- W2740750197 creator A5003231514 @default.
- W2740750197 creator A5014846206 @default.
- W2740750197 creator A5020749615 @default.
- W2740750197 creator A5024067963 @default.
- W2740750197 creator A5026575316 @default.
- W2740750197 creator A5033056518 @default.
- W2740750197 creator A5044497268 @default.
- W2740750197 creator A5046687343 @default.
- W2740750197 creator A5048983493 @default.
- W2740750197 creator A5049348182 @default.
- W2740750197 creator A5050408966 @default.
- W2740750197 creator A5064097008 @default.
- W2740750197 creator A5067842712 @default.
- W2740750197 creator A5067915979 @default.
- W2740750197 creator A5074718723 @default.
- W2740750197 creator A5075250527 @default.
- W2740750197 creator A5080869002 @default.
- W2740750197 date "2017-07-01" @default.
- W2740750197 modified "2023-10-16" @default.
- W2740750197 title "Bioprinted 3D vascularized tissue model for drug toxicity analysis" @default.
- W2740750197 cites W160104111 @default.
- W2740750197 cites W1981684516 @default.
- W2740750197 cites W1983519686 @default.
- W2740750197 cites W2012867417 @default.
- W2740750197 cites W2013520568 @default.
- W2740750197 cites W2020176159 @default.
- W2740750197 cites W2020831247 @default.
- W2740750197 cites W2040482419 @default.
- W2740750197 cites W2061854287 @default.
- W2740750197 cites W2062608800 @default.
- W2740750197 cites W2075924400 @default.
- W2740750197 cites W2078036072 @default.
- W2740750197 cites W2078046184 @default.
- W2740750197 cites W2081061039 @default.
- W2740750197 cites W2084745931 @default.
- W2740750197 cites W2086122328 @default.
- W2740750197 cites W2087315598 @default.
- W2740750197 cites W2094454542 @default.
- W2740750197 cites W2099361891 @default.
- W2740750197 cites W2100081159 @default.
- W2740750197 cites W2102075858 @default.
- W2740750197 cites W2112247582 @default.
- W2740750197 cites W2117935082 @default.
- W2740750197 cites W2121138505 @default.
- W2740750197 cites W2122927773 @default.
- W2740750197 cites W2129322399 @default.
- W2740750197 cites W2130073732 @default.
- W2740750197 cites W2133487725 @default.
- W2740750197 cites W2152239270 @default.
- W2740750197 cites W2152266202 @default.
- W2740750197 cites W2158856031 @default.
- W2740750197 cites W2167279371 @default.
- W2740750197 cites W2186041147 @default.
- W2740750197 cites W2232645088 @default.
- W2740750197 cites W2292693662 @default.
- W2740750197 cites W2295454854 @default.
- W2740750197 cites W2333224948 @default.
- W2740750197 cites W2337513243 @default.
- W2740750197 cites W2509523536 @default.
- W2740750197 cites W2514282006 @default.
- W2740750197 cites W2519647494 @default.
- W2740750197 cites W7512181 @default.
- W2740750197 doi "https://doi.org/10.1063/1.4994708" @default.
- W2740750197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5552405" @default.
- W2740750197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28852429" @default.
- W2740750197 hasPublicationYear "2017" @default.
- W2740750197 type Work @default.
- W2740750197 sameAs 2740750197 @default.
- W2740750197 citedByCount "115" @default.
- W2740750197 countsByYear W27407501972017 @default.
- W2740750197 countsByYear W27407501972018 @default.
- W2740750197 countsByYear W27407501972019 @default.
- W2740750197 countsByYear W27407501972020 @default.
- W2740750197 countsByYear W27407501972021 @default.
- W2740750197 countsByYear W27407501972022 @default.
- W2740750197 countsByYear W27407501972023 @default.
- W2740750197 crossrefType "journal-article" @default.
- W2740750197 hasAuthorship W2740750197A5000860056 @default.
- W2740750197 hasAuthorship W2740750197A5003231514 @default.
- W2740750197 hasAuthorship W2740750197A5014846206 @default.
- W2740750197 hasAuthorship W2740750197A5020749615 @default.
- W2740750197 hasAuthorship W2740750197A5024067963 @default.
- W2740750197 hasAuthorship W2740750197A5026575316 @default.
- W2740750197 hasAuthorship W2740750197A5033056518 @default.
- W2740750197 hasAuthorship W2740750197A5044497268 @default.
- W2740750197 hasAuthorship W2740750197A5046687343 @default.
- W2740750197 hasAuthorship W2740750197A5048983493 @default.
- W2740750197 hasAuthorship W2740750197A5049348182 @default.
- W2740750197 hasAuthorship W2740750197A5050408966 @default.
- W2740750197 hasAuthorship W2740750197A5064097008 @default.
- W2740750197 hasAuthorship W2740750197A5067842712 @default.
- W2740750197 hasAuthorship W2740750197A5067915979 @default.
- W2740750197 hasAuthorship W2740750197A5074718723 @default.
- W2740750197 hasAuthorship W2740750197A5075250527 @default.
- W2740750197 hasAuthorship W2740750197A5080869002 @default.