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- W2740755021 endingPage "151" @default.
- W2740755021 startingPage "142" @default.
- W2740755021 abstract "It is now widely accepted that several gene alterations including transcription factors are critically involved in cancer progression and metastasis. Forkhead Box Class O proteins (FoxOs) including FoxO1/FKHR, FoxO3/FKHRL1, FoxO4/AFX and FoxO6 transcription factors are known to play key roles in proliferation, apoptosis, metastasis, cell metabolism, aging and cancer biology through their phosphorylation, ubiquitination, acetylation and methylation. Though FoxOs are proved to be mainly regulated by upstream phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3 K)/Akt signaling pathway, the role of FoxOs in cancer progression and metastasis still remains unclear so far. Thus, with previous experimental evidences, the present review discussed the role of FoxOs in association with metastasis related molecules including cannabinoid receptor 1 (CNR1), Cdc25A/Cdk2, Src, serum and glucocorticoid inducible kinases (SGKs), CXCR4, E-cadherin, annexin A8 (ANXA8), Zinc finger E-box-binding homeobox 2 (ZEB2), human epidermal growth factor receptor 2 (HER2) and mRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-622, subsequently analyzed the molecular mechanism of some natural compounds targeting FoxOs and finally suggested future research directions in cancer progression and metastasis." @default.
- W2740755021 created "2017-08-08" @default.
- W2740755021 creator A5022942037 @default.
- W2740755021 creator A5031458800 @default.
- W2740755021 creator A5031859132 @default.
- W2740755021 creator A5040801095 @default.
- W2740755021 creator A5056808298 @default.
- W2740755021 creator A5065614169 @default.
- W2740755021 creator A5069167592 @default.
- W2740755021 creator A5075280225 @default.
- W2740755021 date "2018-06-01" @default.
- W2740755021 modified "2023-10-14" @default.
- W2740755021 title "Role of Forkhead Box Class O proteins in cancer progression and metastasis" @default.
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