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- W2740798529 abstract "Summary to examine this downregulatory response, we have con- ducted studies in both T cell lines and in HeLa cells. Nonsense-associated altered splicing (NAS) is a puta- We found that this downregulatory response has sometivecorrection responsethat upregulatesalternatively characteristics typical of NMD, such as the ability to be spliced transcripts that have skipped offending pre- triggered by PTCs at various positions. matureterminationcodons(PTCs).Here,weexamined Like many other mammalian transcripts, PTC TCR whetherNAShascharacteristicsincommonwithnon- transcripts are not downregulated in the cytoplasmic sense-mediated decay (NMD), a surveillance mecha- fraction but instead in the nuclear fraction (Carter et al., nism that degrades PTC-bearing mRNAs. We discov- 1996). Further evidence for the paradoxical involvement ered that although NAS shared the need for a Kozak ofthenucleusinTCR NMDisthefindingthatitrequires AUG to define frame, it differed from NMD. NAS was at least one intron downstream of the stop codon. We" @default.
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- W2740798529 date "2002-01-01" @default.
- W2740798529 modified "2023-09-27" @default.
- W2740798529 title "Short Article Nonsense-Associated Altered Splicing: A Frame-Dependent Response Distinct from Nonsense-Mediated Decay" @default.
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