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- W2740803049 abstract "Caspase activation plays a crucial role in skeletal muscle differentiation. We previously found that caspase-2 activity increases during skeletal muscle cell differentiation; however, its direct effect on differentiation has not been fully investigated. Here, we found that caspase-2 activity transiently increased more than two-fold within 24h following induction of differentiation. Both pharmacological inhibition and shRNA-mediated knockdown of caspase-2 suppressed myogenic differentiation and dramatically impaired myotube formation. Furthermore, shRNA-mediated knockdown prevented induction of p21 and altered cell cycle profiles. Interestingly, caspase-3 activity was also dramatically reduced following caspase-2 inhibition or ablation. Moreover, caspase-2 and p21 were localized to the nucleus during early differentiation. Given the nuclear localization of caspase-2 and p21, as well as the impairment in p21 induction in caspase-2 knockdown cells, we propose that the role of caspase-2 is to regulate p21 induction at the onset of differentiation, which may regulate the myogenic program. Collectively, these results highlight a novel function for caspase-2 in myocyte differentiation and myogenesis." @default.
- W2740803049 created "2017-08-08" @default.
- W2740803049 creator A5013877671 @default.
- W2740803049 creator A5041105609 @default.
- W2740803049 creator A5064375243 @default.
- W2740803049 date "2018-01-01" @default.
- W2740803049 modified "2023-10-04" @default.
- W2740803049 title "Caspase-2 is required for skeletal muscle differentiation and myogenesis" @default.
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- W2740803049 doi "https://doi.org/10.1016/j.bbamcr.2017.07.016" @default.
- W2740803049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28765049" @default.
- W2740803049 hasPublicationYear "2018" @default.
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