FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740809724> ?p ?o ?g. }

• W2740809724 abstract "Pancreatic cancer is a mostly untreatable malignancy, with 5-year survival rates of about 5%. Life-style and dietary factors have been associated with pancreatic cancer risk. Particularly, the consumption of high-fat diets and obesity (and underlying metabolic dysfunction) have been linked to increased susceptibility to this cancer. Recent studies have shown that the paternal diet and life-style can have a significant influence on offspring’s health via epigenetic information transmitted in the germ-line. Paternal overweight before conception has been shown to increase offspring’s susceptibility of developing metabolic diseases and some types of cancer. Here, we evaluated the effects of paternal overweight in the susceptibility of pancreatic cancer in offspring using the P48Cre/+ /KrasG120/+ mouse model of pancreatic cancer. LSL-KrasG120/+ and P48Cre/+ male mice were fed either an obesity-inducing (OID) or control (CO) diet for 8 weeks from weaning to sexual maturity. After this period, OID-fed and CO-fed male mice were housed together with 7 week-old female mice, with free access to CO diet, for 3 days. Pregnant dams were kept on the CO diet during pregnancy and after giving birth. Pups were weaned from mothers at 21 days of age, fed a standard chow diet for the extent of the study and weighed weekly. The offspring of CO or OID fathers were used to study body weight, metabolic parameters and pancreatic cancer development. Fathers fed an OID gained significantly more weight (CO 15.7±1.0g; OID 19.7±1.3g, p=0.02) and had higher leptin levels (p=0.04), compare to CO group fathers. Body weight analyses of OID and CO offspring, showed gender-specific effects. While the OID female offspring had higher weight at birth (p=0.005) and at weaning (p=0.02), compare to CO group, no significant differences were observed between the CO and OID male offspring. Those gender-specific differences were also observed in metabolic parameters such GTT with the OID male, but not female, offspring showing impaired glucose tolerance (p=0.0004) compared to CO. While the monitoring period is still ongoing, 8-week old OID offspring present gender-specific differences in susceptibility to pancreatic cancer: Males OID offspring have higher number/area (481±25; 2.6±0.3) of pancreatic intraepithelial neoplasia (PanIn), compared to CO (359±61; 2.0±0.5). On the other hand, female OID offspring have similar levels of PanIn, but have higher incidence of PDACs compare to CO. In conclusion, an ancestral history of overweight through the paternal lineage may be associated with an increased susceptibility to pancreatic cancer development in adulthood. The mechanisms mediating this effect remain to be elucidated. Citation Format: Raquel Santana Da Cruz, Johan Clarke, Ali Baird, Hong Cao, Carlos Benitez, M. Idalia Cruz, Sonia De Assis. Paternal intake of an obesity-inducing diet before conception modulates the risk of pancreatic cancer in offspring in a mouse model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2404. doi:10.1158/1538-7445.AM2017-2404" @default.
• W2740809724 created "2017-08-08" @default.
• W2740809724 creator A5012087969 @default.
• W2740809724 creator A5020391084 @default.
• W2740809724 creator A5030672232 @default.
• W2740809724 creator A5051013545 @default.
• W2740809724 creator A5061174868 @default.
• W2740809724 creator A5067588306 @default.
• W2740809724 creator A5068523221 @default.
• W2740809724 date "2017-07-01" @default.
• W2740809724 modified "2023-09-27" @default.
• W2740809724 title "Abstract 2404: Paternal intake of an obesity-inducing diet before conception modulates the risk of pancreatic cancer in offspring in a mouse model" @default.
• W2740809724 doi "https://doi.org/10.1158/1538-7445.am2017-2404" @default.
• W2740809724 hasPublicationYear "2017" @default.
• W2740809724 type Work @default.
• W2740809724 sameAs 2740809724 @default.
• W2740809724 citedByCount "0" @default.
• W2740809724 crossrefType "proceedings-article" @default.
• W2740809724 hasAuthorship W2740809724A5012087969 @default.
• W2740809724 hasAuthorship W2740809724A5020391084 @default.
• W2740809724 hasAuthorship W2740809724A5030672232 @default.
• W2740809724 hasAuthorship W2740809724A5051013545 @default.
• W2740809724 hasAuthorship W2740809724A5061174868 @default.
• W2740809724 hasAuthorship W2740809724A5067588306 @default.
• W2740809724 hasAuthorship W2740809724A5068523221 @default.
• W2740809724 hasConcept C112672928 @default.
• W2740809724 hasConcept C121608353 @default.
• W2740809724 hasConcept C126322002 @default.
• W2740809724 hasConcept C134018914 @default.
• W2740809724 hasConcept C147583825 @default.
• W2740809724 hasConcept C2779234561 @default.
• W2740809724 hasConcept C2780210213 @default.
• W2740809724 hasConcept C2780320433 @default.
• W2740809724 hasConcept C2780586474 @default.
• W2740809724 hasConcept C2780655333 @default.
• W2740809724 hasConcept C42407357 @default.
• W2740809724 hasConcept C511355011 @default.
• W2740809724 hasConcept C54355233 @default.
• W2740809724 hasConcept C71924100 @default.
• W2740809724 hasConcept C86803240 @default.
• W2740809724 hasConceptScore W2740809724C112672928 @default.
• W2740809724 hasConceptScore W2740809724C121608353 @default.
• W2740809724 hasConceptScore W2740809724C126322002 @default.
• W2740809724 hasConceptScore W2740809724C134018914 @default.
• W2740809724 hasConceptScore W2740809724C147583825 @default.
• W2740809724 hasConceptScore W2740809724C2779234561 @default.
• W2740809724 hasConceptScore W2740809724C2780210213 @default.
• W2740809724 hasConceptScore W2740809724C2780320433 @default.
• W2740809724 hasConceptScore W2740809724C2780586474 @default.
• W2740809724 hasConceptScore W2740809724C2780655333 @default.
• W2740809724 hasConceptScore W2740809724C42407357 @default.
• W2740809724 hasConceptScore W2740809724C511355011 @default.
• W2740809724 hasConceptScore W2740809724C54355233 @default.
• W2740809724 hasConceptScore W2740809724C71924100 @default.
• W2740809724 hasConceptScore W2740809724C86803240 @default.
• W2740809724 hasLocation W27408097241 @default.
• W2740809724 hasOpenAccess W2740809724 @default.
• W2740809724 hasPrimaryLocation W27408097241 @default.
• W2740809724 hasRelatedWork W1579991606 @default.
• W2740809724 hasRelatedWork W1978526459 @default.
• W2740809724 hasRelatedWork W2016172328 @default.
• W2740809724 hasRelatedWork W2022535578 @default.
• W2740809724 hasRelatedWork W2087268884 @default.
• W2740809724 hasRelatedWork W2109654257 @default.
• W2740809724 hasRelatedWork W2152569113 @default.
• W2740809724 hasRelatedWork W2334634222 @default.
• W2740809724 hasRelatedWork W2522808902 @default.
• W2740809724 hasRelatedWork W2803934608 @default.
• W2740809724 hasRelatedWork W2884781802 @default.
• W2740809724 hasRelatedWork W2888790723 @default.
• W2740809724 hasRelatedWork W2903911742 @default.
• W2740809724 hasRelatedWork W2948553160 @default.
• W2740809724 hasRelatedWork W2977572339 @default.
• W2740809724 hasRelatedWork W2977856971 @default.
• W2740809724 hasRelatedWork W2983129453 @default.
• W2740809724 hasRelatedWork W3033735478 @default.
• W2740809724 hasRelatedWork W3116578897 @default.
• W2740809724 hasRelatedWork W3176138451 @default.
• W2740809724 isParatext "false" @default.
• W2740809724 isRetracted "false" @default.
• W2740809724 magId "2740809724" @default.
• W2740809724 workType "article" @default.