FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740895736> ?p ?o ?g. }

• W2740895736 endingPage "2821" @default.
• W2740895736 startingPage "2811" @default.
• W2740895736 abstract "The thirteen-lined ground squirrel (I. tridecemlineatus) becomes hypometabolic during hibernation; characterized by reductions in energy expensive processes like transcription during periods of low temperature and starvation. We were interested in elucidating the mechanisms of transcriptional control by studying the MAPK pathway and downstream transcription factors in skeletal muscle. We were also interested in how environmental factors, such as body temperature, that fluctuate during hibernation, can affect transcriptional regulation. Protein abundance of MAPKs and effectors were quantified using immunoblotting and Luminex® multiplex assays. DNA-protein interaction (DPI)-ELISA was used to quantitatively assess the binding of transcription factors to DNA promoter sequences under environmental conditions which are reflective of those during torpor. JNK2/3 showed increases in protein abundance during early arousal. The transcription factor, Elk1, showed increases in phosphorylation of S383 (which is indicative of increased activity) during arousal that accompany decreases in total protein levels. Further analysis on the relative binding of this transcription factor to its consensus sequence during euthermia and torpor showed that its binding is significantly different when environmental conditions such as temperature, [urea], and [Ca2 +] were changed. We show evidence of Elk1 regulation during hibernation, and its activity could be influenced by environmental factors such as temperature, [urea] and [Ca2 +], as well as post-translational modifications via JNK2/3. I. tridecemlineatus has natural mechanisms of transcriptional regulation during hibernation through phosphorylation and changes to the cellular environment. We identify regulation of JNK and Elk1 in the skeletal muscle of hibernating I. tridecemlineatus." @default.
• W2740895736 created "2017-08-08" @default.
• W2740895736 creator A5032528144 @default.
• W2740895736 creator A5078699661 @default.
• W2740895736 creator A5084682391 @default.
• W2740895736 date "2017-11-01" @default.
• W2740895736 modified "2023-10-02" @default.
• W2740895736 title "MAP kinase signaling and Elk1 transcriptional activity in hibernating thirteen-lined ground squirrels" @default.
• W2740895736 cites W1023177981 @default.
• W2740895736 cites W137936598 @default.
• W2740895736 cites W1539871462 @default.
• W2740895736 cites W1880958846 @default.
• W2740895736 cites W1964940783 @default.
• W2740895736 cites W1969528211 @default.
• W2740895736 cites W1972145919 @default.
• W2740895736 cites W1975628707 @default.
• W2740895736 cites W1976418244 @default.
• W2740895736 cites W1980700473 @default.
• W2740895736 cites W1980813826 @default.
• W2740895736 cites W1982420240 @default.
• W2740895736 cites W1984339303 @default.
• W2740895736 cites W1985613058 @default.
• W2740895736 cites W1992544914 @default.
• W2740895736 cites W1993722975 @default.
• W2740895736 cites W1995563118 @default.
• W2740895736 cites W1997308071 @default.
• W2740895736 cites W2002060477 @default.
• W2740895736 cites W2002282120 @default.
• W2740895736 cites W2004797086 @default.
• W2740895736 cites W2005510844 @default.
• W2740895736 cites W2011013384 @default.
• W2740895736 cites W2011729627 @default.
• W2740895736 cites W2014527289 @default.
• W2740895736 cites W2014626069 @default.
• W2740895736 cites W2014938307 @default.
• W2740895736 cites W2017856783 @default.
• W2740895736 cites W2019010829 @default.
• W2740895736 cites W2024893804 @default.
• W2740895736 cites W2026389064 @default.
• W2740895736 cites W2027552568 @default.
• W2740895736 cites W2028333426 @default.
• W2740895736 cites W2031272027 @default.
• W2740895736 cites W2031484455 @default.
• W2740895736 cites W2033717682 @default.
• W2740895736 cites W2041308924 @default.
• W2740895736 cites W2042985795 @default.
• W2740895736 cites W2043975343 @default.
• W2740895736 cites W2047667443 @default.
• W2740895736 cites W2050102939 @default.
• W2740895736 cites W2052591083 @default.
• W2740895736 cites W2054330377 @default.
• W2740895736 cites W2055082208 @default.
• W2740895736 cites W2055380229 @default.
• W2740895736 cites W2074664011 @default.
• W2740895736 cites W2075512365 @default.
• W2740895736 cites W2080345500 @default.
• W2740895736 cites W2083624932 @default.
• W2740895736 cites W2088359631 @default.
• W2740895736 cites W2090278216 @default.
• W2740895736 cites W2093393970 @default.
• W2740895736 cites W2110212291 @default.
• W2740895736 cites W2112242064 @default.
• W2740895736 cites W2114175462 @default.
• W2740895736 cites W2115704680 @default.
• W2740895736 cites W2118457425 @default.
• W2740895736 cites W2122057254 @default.
• W2740895736 cites W2128968541 @default.
• W2740895736 cites W2130166595 @default.
• W2740895736 cites W2134812490 @default.
• W2740895736 cites W2135943549 @default.
• W2740895736 cites W2136904722 @default.
• W2740895736 cites W2137146542 @default.
• W2740895736 cites W2140929616 @default.
• W2740895736 cites W2143629844 @default.
• W2740895736 cites W2155124532 @default.
• W2740895736 cites W2158627852 @default.
• W2740895736 cites W2162586563 @default.
• W2740895736 cites W2165113402 @default.
• W2740895736 cites W2168750820 @default.
• W2740895736 cites W2170522474 @default.
• W2740895736 cites W2171370330 @default.
• W2740895736 cites W2258710488 @default.
• W2740895736 cites W2335302313 @default.
• W2740895736 cites W2407364126 @default.
• W2740895736 cites W2465487218 @default.
• W2740895736 cites W2562726621 @default.
• W2740895736 cites W2577649235 @default.
• W2740895736 doi "https://doi.org/10.1016/j.bbagen.2017.07.026" @default.
• W2740895736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28778486" @default.
• W2740895736 hasPublicationYear "2017" @default.
• W2740895736 type Work @default.
• W2740895736 sameAs 2740895736 @default.
• W2740895736 citedByCount "8" @default.
• W2740895736 countsByYear W27408957362018 @default.
• W2740895736 countsByYear W27408957362019 @default.
• W2740895736 countsByYear W27408957362020 @default.
• W2740895736 countsByYear W27408957362021 @default.
• W2740895736 countsByYear W27408957362022 @default.

• next