FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2740901996> ?p ?o ?g. }

• W2740901996 abstract "ABSTRACT Loss-of-function mutations in 3′-to-5′ exoribonucleases have been implicated in hereditary human diseases. For example, PARN mutations cause a severe form of dyskeratosis congenita (DC), wherein PARN deficiency leads to human telomerase RNA instability. Since the DC phenotype in PARN patients is even more severe than that of loss-of-function alleles in telomerase components, we hypothesized that PARN would also be required for the stability of other RNAs. Here, we show that PARN depletion reduces the levels of abundant human Y RNAs, which might contribute to the severe phenotype of DC observed in patients. Depletion of PAPD5 or the cytoplasmic exonuclease DIS3L rescues the effect of PARN depletion on Y RNA levels, suggesting that PARN stabilizes Y RNAs by removing oligoadenylated tails added by PAPD5, which would otherwise recruit DIS3L for Y RNA degradation. Through deep sequencing of 3′ ends, we provide evidence that PARN can also deadenylate the U6 and RMRP RNAs without affecting their levels. Moreover, we observed widespread posttranscriptional oligoadenylation, uridylation, and guanylation of U6 and Y RNA 3′ ends, suggesting that in mammalian cells, the formation of a 3′ end for noncoding RNAs can be a complex process governed by the activities of various 3′-end polymerases and exonucleases." @default.
• W2740901996 created "2017-08-08" @default.
• W2740901996 creator A5014796446 @default.
• W2740901996 creator A5043724875 @default.
• W2740901996 date "2017-10-15" @default.
• W2740901996 modified "2023-10-12" @default.
• W2740901996 title "PARN Modulates Y RNA Stability and Its 3′-End Formation" @default.
• W2740901996 cites W1871134247 @default.
• W2740901996 cites W1977487937 @default.
• W2740901996 cites W1981074253 @default.
• W2740901996 cites W1987279431 @default.
• W2740901996 cites W1987722665 @default.
• W2740901996 cites W1988260660 @default.
• W2740901996 cites W1988309554 @default.
• W2740901996 cites W1991588710 @default.
• W2740901996 cites W1995294811 @default.
• W2740901996 cites W1998739058 @default.
• W2740901996 cites W2001377906 @default.
• W2740901996 cites W2020527412 @default.
• W2740901996 cites W2021084841 @default.
• W2740901996 cites W2025859016 @default.
• W2740901996 cites W2026502985 @default.
• W2740901996 cites W2031420898 @default.
• W2740901996 cites W2031632944 @default.
• W2740901996 cites W2032486291 @default.
• W2740901996 cites W2032501207 @default.
• W2740901996 cites W2052385759 @default.
• W2740901996 cites W2055643663 @default.
• W2740901996 cites W2059631022 @default.
• W2740901996 cites W2077746165 @default.
• W2740901996 cites W2089004878 @default.
• W2740901996 cites W2089169921 @default.
• W2740901996 cites W2091238367 @default.
• W2740901996 cites W2095676095 @default.
• W2740901996 cites W2096303318 @default.
• W2740901996 cites W2099925408 @default.
• W2740901996 cites W2106838809 @default.
• W2740901996 cites W2116242840 @default.
• W2740901996 cites W2120959840 @default.
• W2740901996 cites W2121035089 @default.
• W2740901996 cites W2126028648 @default.
• W2740901996 cites W2129232563 @default.
• W2740901996 cites W2140406771 @default.
• W2740901996 cites W2145211380 @default.
• W2740901996 cites W2158411073 @default.
• W2740901996 cites W2161375720 @default.
• W2740901996 cites W2164971228 @default.
• W2740901996 cites W2176579203 @default.
• W2740901996 cites W2178007530 @default.
• W2740901996 cites W2179053602 @default.
• W2740901996 cites W2179796260 @default.
• W2740901996 cites W2242326750 @default.
• W2740901996 cites W2252902406 @default.
• W2740901996 cites W2300198160 @default.
• W2740901996 cites W2302428187 @default.
• W2740901996 cites W2330702948 @default.
• W2740901996 cites W2411897318 @default.
• W2740901996 cites W2499490878 @default.
• W2740901996 cites W2505124553 @default.
• W2740901996 cites W2578261095 @default.
• W2740901996 cites W2591203372 @default.
• W2740901996 cites W748047530 @default.
• W2740901996 doi "https://doi.org/10.1128/mcb.00264-17" @default.
• W2740901996 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5615183" @default.
• W2740901996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28760775" @default.
• W2740901996 hasPublicationYear "2017" @default.
• W2740901996 type Work @default.
• W2740901996 sameAs 2740901996 @default.
• W2740901996 citedByCount "29" @default.
• W2740901996 countsByYear W27409019962018 @default.
• W2740901996 countsByYear W27409019962019 @default.
• W2740901996 countsByYear W27409019962020 @default.
• W2740901996 countsByYear W27409019962021 @default.
• W2740901996 countsByYear W27409019962022 @default.
• W2740901996 countsByYear W27409019962023 @default.
• W2740901996 crossrefType "journal-article" @default.
• W2740901996 hasAuthorship W2740901996A5014796446 @default.
• W2740901996 hasAuthorship W2740901996A5043724875 @default.
• W2740901996 hasBestOaLocation W27409019961 @default.
• W2740901996 hasConcept C104317684 @default.
• W2740901996 hasConcept C179255354 @default.
• W2740901996 hasConcept C2777501222 @default.
• W2740901996 hasConcept C501734568 @default.
• W2740901996 hasConcept C54355233 @default.
• W2740901996 hasConcept C62203573 @default.
• W2740901996 hasConcept C67705224 @default.
• W2740901996 hasConcept C82381507 @default.
• W2740901996 hasConcept C86803240 @default.
• W2740901996 hasConcept C95444343 @default.
• W2740901996 hasConceptScore W2740901996C104317684 @default.
• W2740901996 hasConceptScore W2740901996C179255354 @default.
• W2740901996 hasConceptScore W2740901996C2777501222 @default.
• W2740901996 hasConceptScore W2740901996C501734568 @default.
• W2740901996 hasConceptScore W2740901996C54355233 @default.
• W2740901996 hasConceptScore W2740901996C62203573 @default.
• W2740901996 hasConceptScore W2740901996C67705224 @default.
• W2740901996 hasConceptScore W2740901996C82381507 @default.
• W2740901996 hasConceptScore W2740901996C86803240 @default.
• W2740901996 hasConceptScore W2740901996C95444343 @default.
• W2740901996 hasFunder F4320306082 @default.

• next